PubMed Health⌕ Search

Biomedical subjects

J H Naude

Publications and source records attributed to J H Naude.

10 recordsLinked to original sources
PubMed1999

Buccal mucosal grafts in the treatment of ureteric lesions.

OBJECTIVE: To devise a procedure capable of curing complicated ureteric strictures and replacing segments of lost ureter, without the long-term infective complications of bowel interposition or the surgical magnitude of autotransplantation. PATIENTS AND METHODS: Four patients with complicated strictures and one with segmental ureteric loss were treated by buccal mucosal patch grafts and an omental wrap. One patient with segmental ureteric loss was treated by interposition of a tubularized buccal mucosal graft. RESULTS: Ureteric patency was established and maintained in all patients, there were no complications and urine was sterile in all patients at follow-up. CONCLUSION: In a few patients, buccal mucosal patch graft repair has proved capable of maintaining patency and good urinary drainage in patients with complicated ureteric strictures. Segmental ureteric loss has been replaced in one patient by a patch graft and in another by tubularized graft interposition.

Adult↗
PubMed1999

Topical vasoactive cream in the treatment of erectile failure: a prospective, randomized placebo-controlled trial.

OBJECTIVE: To repeat a previous study on the use of a topical treatment for erectile failure using a vasoactive cream. PATIENTS AND METHODS: Fourteen patients with erectile failure who had previously responded to intracorporeal injection therapy were enrolled in a randomized placebo-controlled trial. They were given two topical applications, comprising either a cream containing aminophylline, isosorbide dinitrate and co-dergocrine mesylate, or a placebo cream of similar appearance containing no pharmacologically active ingredients. Each patient received 16 applications, eight of the active cream and eight placebo. The creams were applied alternatively on successive occasions and the results recorded. RESULTS: The active cream, applied on 77 occasions, resulted in three good and 13 partial erections. The placebo cream, applied on 76 occasions, yielded four good and 13 partial erections. CONCLUSIONS: We were unable to reproduce the successful results reported by others; in the present study the active cream performed no better than placebo.

Adult↗
PubMed1984

Segmental ureteric replacement: an animal study using a free non-pedicled graft.

An animal study has been carried out on 3 baboons to assess the feasibility of replacing a damaged segment of ureter with a free, non-pedicled, full thickness graft. A 3 cm segment was excised from the middle third of one ureter from each baboon and the free graft (buccal mucosa) fashioned into a tube and interposed between the cut ends in order to replace the excised segment. The grafts were left in situ for up to 10 weeks and their subsequent fate studied radiologically, histologically and by gross specimen examination. The results showed that in all cases perfect viability of the graft was maintained and there was no evidence of graft shrinkage or of loss of patency. In one instance a stricture developed at the mid point of the graft, but this was entirely explicable on technical grounds. Urine drainage was not impaired on account of the insertion of a muscle-free (and therefore aperistaltic) segment into the ureter.

Animals↗
PubMed1984

The natural history of ureteric Bilharzia.

A prospective study of apparent obstruction of the ureter by Bilharzia was undertaken. Over a 2-year period, 130 patients with active Bilharzia and 58 patients with inactive or chronic Bilharzia, all of whom had apparently obstructive lesions of the ureter, were studied. Ureteric lesions were examined for true mechanical obstruction by post-micturition erect radiography, erect diuresis renography and, in selected cases, by perfusion pressure flow studies. Of the 130 patients with active Bilharzia, 32 ureters were found to be mechanically obstructed and in each case the obstruction resolved with anti-bilharzial medication. Of the 58 patients with chronic or inactive lesions, only 5 ureters were found to be truly obstructed and required surgery. It is concluded that surgery is unnecessary for ureters obstructed by active Bilharzia within 2 months of starting treatment because the obstruction will resolve in most patients. In the so-called chronic bilharzial stricture, obstruction is more apparent than real and thorough investigation will save many patients from unnecessary surgery.

Humans↗
PubMed1982

The hidden vesicostomy.

A continent vesicostomy has been developed by the use of a tubed bladder flap brought to the skin superficial to the pubic bone and with the stoma sited in the labio-clitoral fold, usually on the right, in right-handed patients. This technique has found application, initially in cases of vesicovaginal fistula, where the continence mechanism has been completely destroyed, and later has been applied to cases of neurogenic bladder due to meningomyelocoele. This operation has been performed on 20 patients. With the exception of our first patient, a technical failure, all patients have been fully continent, the majority on intermittent self-catheterisation. The situation of the stoma facilitates self-catheterisation and the stoma is not visible unless the thighs are abducted and the labia deliberately separated. In patients with a small bladder capacity, augmentation cystoplasty has been done. In males the stoma cannot be so well hidden, although it is not very obvious at the root of the penis in the pubic hair. This operation offers full continence of urine on intermittent catheterisation and the hope of an acceptable body image.

Child↗