PubMed Health⌕ Search

Biomedical subjects

J H Poole

Publications and source records attributed to J H Poole.

3 recordsLinked to original sources
PubMed1991

Negative symptoms in schizophrenia and nailfold plexus visibility.

Visibility of the nailfold vascular plexus has shown promise as a genetically transmitted marker for liability to schizophrenia. To assess whether this marker is specifically associated with negative or positive symptoms of schizophrenia, we reanalyzed patient data collected 20 years ago, well before interest in the negative/positive symptom distinction. Eighty-four patients, who retrospectively met DSM-III-R criteria for schizophrenia, had been rated for plexus visualization score (PVS) and independently interviewed using the Mental Status Schedule (MSS). Content scales were derived from the MSS to assess negative, positive, and affective symptoms. There was a highly significant correlation between PVS and negative symptoms (including verbal, motor, cognitive and motivational deficits), but not between PVS and positive or affective symptoms. These findings indicate that the negative symptoms of schizophrenia are due to a disease process biologically distinguishable from those causing positive symptoms and that plexus visibility is a risk marker for this pathology.

Adolescent↗
PubMed1990

Attention deficit disorder and the mediating effect of age on academic and behavioral variables.

Seventy-nine children, independently diagnosed as having attention deficit disorder (ADD) with or without hyperactivity and ranging in age from 6 years, 0 months, to 12 years, 11 months, were administered the Wechsler Intelligence Scale for Children-Revised (WISC-R), the Wide Range Achievement Test (WRAT), and the Child Behavior Checklist (CBC). Multiple regression analyses indicated a significant multiple correlation between age and achievement variables (R = 0.42, p = 0.003) and age and behavioral (CBC) variables (R = 0.55, p = 0.01). Post hoc analyses indicated that much of this variance was accounted for by a significant negative association between age and Full Scale IQ-WRAT Arithmetic difference scores, and significant positive correlations between age and scores on the Social Withdrawal and Uncommunicative scales from the CBC. A nonparametric chi-square analysis indicated that older children with ADD are significantly more likely (p = 0.037) than younger ADD children to have a discrepancy of 15 or more points between IQ and math achievement scores. Results suggest that older ADD children are more likely than younger ADD children to experience academic and socioemotional difficulties.

Achievement↗