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Biomedical subjects

J H Pritchard

Publications and source records attributed to J H Pritchard.

8 recordsLinked to original sources

Ultrasonography of the testis--correlation with radiotracer perfusion.

Ultrasonic study of testicular disease and paratesticular masses was carried out in 20 cases. In eight of these, comparison was made with pertechnetate perfusion studies performed concurrently. Testicular torsion was well revealed by both techniques. Acute orchitis, in the early stages, was shown more clearly by radiotracer, unless there was associated epididymal swelling or hydrocele. Chronic complications of inflammation, particularly abscess formation, were seen best by ultrasonography. Paratesticular masses could be studied only by ultrasound. These included both solid and cystic masses due to chronic epididymitis.

Adult↗

Multiform thyroid cancer-scintigraphic and echographic features.

In a patient with multinodular goiter, one of the three solid nodules harboring follicular carcinoma appeared functional in the 99mTc-pertechnetate image, yet "cystic" in both A-and B-mode echogram studies. The other two nodules corresponded in their image and echogram features and contained papillary and anaplastic carcinomas, and Hashimoto's thyroiditis. Clinical acumen proved to be the best guide in the management of this patient.

Adenocarcinoma↗

Indium-111-labeled antibody heavy metal chelate conjugates: a potential alternative to radioiodination.

An alternative method to radioiodination is outlined for labeling antibodies with a radioactive marker. The method requires the conjugation of the antibody molecule to chelating agents that contain a free amino group and are capable of binding heavy metal ions. Glutaraldehyde is the coupling agent used to bridge the free amino groups on both the chelate and the antibody molecules. 111In is then added to the antibody-chelate conjugate and is bound instantaneously by the chelating portion. Electrophoretic, autoradiographic, immunodiffusion, and hemagglutination techniques were used to confirm the integrity of the 111In-labeled antibodies.

Antigen-Antibody Reactions↗