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J H RUST

Publications and source records attributed to J H RUST.

At least 19 recordsLinked to original sources
PubMed1965

DETECTION OF AN ENZOOTIC PLAGUE FOCUS BY SEROLOGICAL METHODS.

Complement-fixation and haemagglutination tests, utilizing a highly purified, specific Fraction 1 antigen of Pasteurella pestis, have been employed to detect specific plague antibody in the sera of rodents resident in a sylvatic plague focus. The data show that while the isolation of P. pestis is seasonal and rather rare, antibodies can be detected for long periods of time and with great frequency in rodents surviving infection. The authors recommend that serological methods be incorporated into epidemiological surveys and control programmes involving rodent plague.

Animals↗
PubMed1965

CHOLERA IN EAST PAKISTAN FAMILIES, 1962-63. PAKISTAN-SEATO CHOLERA RESEARCH LABORATORY.

The families of 85 cholera patients hospitalized during 1962-63 in Dacca District, East Pakistan, were studied in order to determine the relationship between familial and individual characteristics and the spread of the disease. Details of the circumstances, personal characteristics and medical history of the family members were recorded, and daily visits were made over a two-week period by a team of physicians and sociologists. Secondary cases were observed in 33 of the 85 families. Secondary attack rates were higher among children than adults. Spread of cholera within these families was suggested by the distribution of intervals between primary and subsequent cases, by the relationship between lengthy home stay of index cases and increased numbers of secondary cases, and by the effect of family structure on secondary attack rates.

Adult↗
PubMed1963

PLAGUE TOXIN: ITS EFFECT IN VITRO AND IN VIVO.

The murine toxin of Pasteurella pestis inhibited the respiration of heart mitochondria from the rat and the mouse but had little or no effect on the respiration of mitochondria from the rabbit, chimpanzee, dog, and monkey. Alterations occurred in tile S-T segments of the electrocardiogramus recorded corded from rats injected with (1/4) to 10 LD(50) of toxin, but not in those from rats dying of hemorrhagic shock, hypoxia, intoxication with glucose, or Escherichia coli endotoxin. No abnormalities were observed in electrocardiograms from rabbits injected with large amounts of toxin.

Animals↗
PubMed1963

ACTION OF PLAGUE MURINE TOXIN ON MITOCHONDRIA FROM RESISTANT AND SUSCEPTIBLE ANIMALS.

Kadis, Solomon (Albert Einstein Medical Center, Philadelphia, Pa.), Samuel J. Ajl, and James H. Rust, Jr. Action of plague murine toxin on mitochondria from resistant and susceptible animals. J. Bacteriol. 86:757-765. 1963.-Purified murine Pasteurella pestis toxin inhibited the respiration of liver mitochondria isolated from both the rat and the rabbit. Toxin had little or no effect on the respiration of rabbit sarcosomes, but when they were disrupted with either sodium deoxycholate or sonic vibration their respiration was inhibited. The respiration of heart mitochondria from rats immunized with toxoid-adjuvant mixtures was inhibited only slightly by the toxin, whereas the respiration of liver mitochondria from immunized rats was inhibited to the same degree as that from nonimmunized animals. Toxin caused the heart mitochondria of the rat to swell, but had little or no effect on the heart mitochondria of the rabbit. Also, brain mitochondria were not swollen by the toxin.

Animals↗