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Biomedical subjects

J H Shaw

Publications and source records attributed to J H Shaw.

8 recordsLinked to original sources
PubMed1978

Remodeling of cancellous bone in young monkeys.

Remodeling of the trabeculae in cancellous bone was studied in young monkeys that received multiple weekly injections of lead acetate as a marker. Resorption of old bone and deposition of new bone were demonstrated. The rate of deposition of new bone varied at different sites of the same trabeculae and also at different time intervals of the same site. The total formation time of new bone to fill the trabecular space was estimated.

Animals↗
PubMed1977

Collaborative evaluation of a rat caries model in six laboratories.

When highly controlled parallel rat caries studies were run simultaneously in six laboratories, a similar pattern of caries developed in every laboratory with a range in mean values such that the results of no investigator were significantly different from those of at least two others. These results indicate that the major factors influencing development of rat caries have been recognized and can be controlled within reasonable limits.

Animals↗
PubMed1977

Remodeling of compact bone studied with lead acetate as an intravital stain.

Remodeling of the osteons or Haversian canal system in compact bone was studied in young monkeys that received serial injections of lead acetate as an intravital strain. The successive stages of the formation of an osteon have been demonstrated. The rate of the filling of the lamellar bone decelerated as the lumen of the Haversian canal decreased. The total formation time of individual osteons was estimated.

Acetates↗
PubMed1977

Effects of repeated ingestion of large quantities of acetylsalicylic acid on membranous bone growth and dentin apposition in young monkeys.

Four daily doses of ASA were administered by mouth to young growing monkeys which received six injections of lead acetate every seven days as an intravital stain to indicate sites of bone and dentin mineralization. Microscopic evaluation of the inhibitory effects on membranous bone growth and dentin apposition was made. Four doses of ASA at 325 mg/kg inhibited membranous bone growth as well as the remodeling of the Haversian canal systems for about 16-18 days, with incomplete recovery during the experimental period. No comparable effect on dentinogenesis was observed. This preliminary study indicates that four doses of ASA at this level caused a toxic effect directly on membranous bone growth but not on dentin apposition.

Administration, Oral↗
PubMedDate not supplied

Inability of low levels of sorbitol and mannitol to support caries activity in rats.

Under the environmental conditions of these experiments, neither 5 nor 10% sorbitol or mannitol in diets containing 62 or 57% corn starch, respectively, was capable of increasing the caries activity in rats above the level supported by a 67% starch diet. In contrast, 5% sucrose in the presence of 62% corn starch caused a slight increase and 10% sucrose in the presence of 57% starch caused a significant increase in caries activity beyond that observed when the diet containing 67% starch as the only carbohydrate was fed.

Animals↗
PubMedDate not supplied

Effects of repeated oral doses of demethylchlortetracycline on bones and dentin of young rhesus monkeys.

Seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. Bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. Cessation of bone growth and its duration could be correlated with serum levels.

Administration, Oral↗