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Biomedical subjects

J H Wyllie

Publications and source records attributed to J H Wyllie.

At least 55 records · Page 3Linked to original sources
PubMed1975

Pharmacological evaluation of cimetidine, a new histamine H2-receptor antagonist, in healthy man.

Cimetidine, a new H2-receptor antagonist, was safely administered to eighteen healthy man by the intravenous, intraduodenal or oral route. 2 When gastric secretion was maximally stimulated by either histamine or pentagastrin, the simultaneous administration of cimetidine produced marked inhibition of both acid and pepsin secretion. 3 Cimetidine was well absorbed by mouth and had a blood half-life of 2 hours. 4 Cimetidine was rapidly excreted via the kidneys and about 70% of the excreted material was unchanged drug. 5 Clinical evaluation of cimetidine in patients with peptic ulceration is recommended.

Administration, Oral↗
PubMed1973

Effect of proximal gastric vagotomy on gastric acid secretion and plasma gastrin.

Sixteen patients underwent proximal gastric vagotomy (highly selective vagotomy) for chronic duodenal ulceration. All were subjected to preoperative and postoperative acid secretion studies. A reduction in the secretory response to pentagastrin and abolition of the response to meat extract occurred postoperatively. Plasma gastrin levels in response to meat extract were studied by radioimmunoassay. Basal plasma gastrin levels were unaffected by vagotomy and it was found that the plasma gastrin response to meat extract was not impaired after operation if the postoperative insulin test was positive. Only if the insulin test was negative was the amount of gastrin released by meat extract reduced.

Duodenal Ulcer↗
PubMed1972

Plasma gastrin and acid secretion in man following stimulation by food, meat extract, and insulin.

A radioimmunoassay for gastrin was set up and its sensitivity and specificity were studied. The assay was then used to investigate the plasma gastrin responses in man to a normal meal and to stimulation by insulin hypoglycaemia or by instilling meat extract into the stomach. The results showed that insulin and meat extract produced very similar plasma gastrin responses which were certainly not less than those produced by feeding. However, the acid secretory response to insulin was greater than that to meat extract. This indicated that the tests acted in different ways and both may be useful in the assessment of gastric secretion.

Animals↗
PubMed1971

Prostaglandins and glaucoma.

Human aqueous humour was found to contain a substance which contracted the rat stomach strip. The mean activity was significantly higher in specimens from open angle glaucoma cases than in specimens from patients with cataract. The pharmacological and chromatographic properties of the active material were studied in aqueous humour obtained from cadavers; activity seemed to be due to prostaglandin E(1). These results suggest that prostaglandin E(1) may play some part in the aetiology of open angle glaucoma.

Aged↗
PubMed1971

The fate of pentagastrin.

Pentagastrin is rapidly removed from the circulation of the dog. It is excreted by the liver into the bile, largely in an inactivated form. Preliminary results indicate that it meets the same fate in man.

Animals↗