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Biomedical subjects

J Höper

Publications and source records attributed to J Höper.

At least 55 records · Page 3Linked to original sources
PubMed1981

[Oxygen tension in skeletal muscle in patients with reduced O2-carrying capacity (author's transl)].

In 10 patients (age: 31--72 years) oxygen supply of skeletal muscle was measured by pO2-multiwire technique. All patients suffered from chronic renal failure of differing etiologies and from chronic renal anemia. In muscle tissue 1,128 different O2-tensions were registered and the results were expressed as pO2-histograms. Seven of these pO2-histograms show a normal distribution, three are shifted to the left to lower O2-tensions. Therefore the microcirculation in the skeletal muscle of patients with chronic reduced O2-carrying capacity is largely undisturbed. The microcirculation is able to increase with exercise as shown by a shift to the right in the PO2-histogram. The use of the pO2-multiwire electrode is largely devoid of risk to the patient. Important pathological features may be demonstrated.

Carbon Dioxide↗
PubMed1978

Action of norepinephrine on microcirculation and PO2 distribution in the isolated perfused rat liver.

The addition of a potent vasoconstrictor, such as norepinephrine, induces an influx of sodium and an efflux of calcium and potassium in the parenchymal cells of the perfused liver. This reaction can be reversed by the addition of dihydroergotoxine mesylate (active substance of Hydergine). The example shows clearly that very distinct biological signals are generated under such conditions at the membrane level of the hepatocytes and presumably of other cells of liver tissue. At present, our investigations cannot clearly answer the question of whether or not swelling the shrinkage of parenchymal cells and of endothelial cells can serve as an additional mechanism for regulating microcirculation.

Animals↗