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Biomedical subjects

J Hübler

Publications and source records attributed to J Hübler.

At least 19 recordsLinked to original sources
PubMed2003

Methylene blue as a means of treatment for priapism caused by intracavernous injection to combat erectile dysfunction.

OBJECTIVE: The authors observed priapism as a side effect occuring during the intracavernous treatment of erectile dysfunction. Earlier priapism had been treated with an intracavernous injection of sympatomimetics; unfortunately several complications and contraindications were found. PATIENTS AND METHODS: Methylene blue was applied in the treatment of five patients. First a corpus cavernosum punction was performed and some blood was aspirated from the penis. Finally 100 mg of Methylthionin Chlorati was injected into the corpus cavernosum. RESULTS: A sufficient detumescence was observed in all of these cases. There were no complications. The method was applied effectively in two cases after an unsuccessful punction. CONCLUSION: The autors recommend intravenous methylene blue for the treatment of priapism. According to their experience this method is free of complications and as effective as a sympathomimetics treatment. As they think, it can be recommended in any manifestations of priapism because its force of action appears to be both chemically and biologically clear.

Enzyme Inhibitors↗
PubMed2000

Tibia metastasis without prostate specific antigen (PSA) increase following radical vesiculo-prostatectomy.

OBJECTIVES: PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels. METHODS: The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an increase in PSA levels. RESULTS: Tibia metastasis showed lower tissue activity of PSA than did the primary tumor in the prostate. The authors think this explains the zero PSA level when the metastasis developed. CONCLUSIONS: The authors think based on their case that PSA free progression prostate cacncers may cases where the metastases do not produce PSA.

Adenocarcinoma↗
PubMed1993

[Reliability and use of prostate-specific antigen in the management of patients with prostatic cancer].

The authors are reporting the clinical importance of prostate specific antigen. They concluded that there are false positive and false negative cases. The prostate specific antigen is high in prostatic hyperplasia therefore the distinction between the two disease is impossible on basis of the prostate specific antigen. Prostate specific antigen shows the metastatic cases better [correction of worse] than prostatic acid phosphatase. But prostate specific antigen detects the changes of the clinical course of the disease well and shows the progression sooner. The authors have concluded that prostate specific antigen can not replace phosphatases and bone-scanning in the diagnosis and follow up of patients with prostate carcinoma.

Acid Phosphatase↗
PubMed1991

[Relationship between histological prognostic indices and clinical course in prostatic carcinoma].

The authors have summarized the relationship between histological differentiation indices and survival rate, hormonal sensitivity time, hormonal resistance time for the past 10 years. The classifications have been made according to Dhom and Gleason. 130 patients have been followed from the time of diagnosis to the time of their death. 95 patients died because of tumour. They found that there is a relationship between the survival rate and indices in those cases who were early diagnosed and they had no metastasis. There was no relationship between hormonal sensitivity time, hormonal resistance time and histological prognostic differentiation indices.

Carcinoma↗
PubMed1991

[Balloon catheter for the dilatation of the urethra].

For the first time in Hungary balloon catheter urethral dilatation have been performed in two cases. Surgical approach for the first case was contraindicated because of poor physical state and cardio-pulmonary diseases. The other patient had urethral stricture and stone incrustation (composed of hair) after he has had urethral reconstructive plastic surgery. The authors have emphasized that internal urethrotomy have been a routine surgical approach for urethral strictura for the past 10 years however, under certain circumstances balloon-urethral dilatation should be applied. The postoperative results were satisfactory. No complications observed. The authors have therefore advised the use of balloon urethral dilatation because it is easy to perform and the results are satisfactory.

Aged↗
PubMed1987

Cytostatic therapy, its value and indications in the management of prostatic carcinoma.

Observations with cytostatic therapy of generalized prostatic carcinoma (PC) over 5 years are reported, cyclophosphamide (cpa) having been administered to hormone-resistant patients. A standard therapeutic and follow-up scheme, enabling the results to be assessed objectively, had been elaborated. Objective remission or stagnation, confirmed on this basis, was attained in 50%, relief of pain in 60% of the cases. Side effects were negligible. Withdrawal of cytostatics was required in 2 cases. The results indicate that secondary cytostatic therapy significantly potentiated the effect of hormone therapy in generalized PC, and in case of hormone resistance it offers the only chance of therapeutic benefit.

Aged↗
PubMed1987

Surgery of calculous hydrocalyx (calyceoplastic surgery).

A modified surgical technique for calculous hydrocalyx, based on partial calyceal resection with simultaneous correction of the morphological abnormality responsible for stone formation is described. Access to the calyx is gained by a modified marginopolar resection. The modification developed by the authors consists in carrying the resection line laterally to the vertical axis of the kidney. The parenchyma is closed by U-shaped "hair-pin" stitches. Preparation of the limbic, pelvic and ureteral areas is abstained from, thus avoiding scarring which might affect renal lymph and blood flow and interfere with urinary transport. The results obtained in 85 cases of calculous hydrocalyx over an 8-year period were satisfactory. The rate of calculous recurrences was not higher than 3.5 per cent.

Humans↗
PubMed1987

Complex treatment and care of prostatic carcinoma patients.

The authors' 5-year experience in the management and care of prostatic carcinoma are summarized. Their method differs essentially from earlier practice. They have found a new diagnostic and therapeutic method by introducing the TECO irradiation therapy, extensively using bone scintigraphy, by introducing cytostatics, extensively applying the prostate-specific acid phosphatase and by performing rectal biopsy of the prostate. They describe their own observations on the diagnostics and therapy of prostatic carcinoma. They stress that none of the therapies is the method of choice, the use of the various kinds of treatment are defined by strict indications. They state that care of prostatic cancer patients is highly important because only observation of the course of the disease may ensure the evaluation of treatment results and the indication of the adequate therapeutic method.

Acid Phosphatase↗
PubMed1986

Induced precipitation of calcium-oxalate crystals and its prevention in laboratory animals.

Induced precipitation of Ca-oxalate crystals and the possibility of its prevention were studied in dogs. In the first phase of the experiments precipitation of Ca-oxalate crystals in canine renal tubules was induced by intraperitoneal administration of Na-glyoxylate. Preventive medication (lipoic acid, vitamin B1, Milurit), applied in the second phase, resulted in a significant depression of induced precipitation. The successful experiments serve as a basis for clinical research aimed at a preventive medication of recurrent Ca-oxalate stone formation.

Animals↗
PubMed1985

Parenchymal operations of the lower pole of the kidney with a double collecting system.

The authors present four cases of unilateral kidney with a double collecting system where calculous change has occurred in the lower collecting system. In one of them, marginopolar nephrotomy, while in three, heminephrectomies in the destructed lower segment of the kidney were performed. The remaining upper part functioned perfectly later on. The avoidance of unjustified nephrectomy is stressed.

Adolescent↗
PubMed1982

Combined oral and local therapy for the dissolution of urinary calculi.

The factors underlying the formation of Ca-phosphate and struvite calculi, as well as the present possibilities for oral and local therapy, their advantages and drawbacks are discussed in the light of published evidence. In this context a clinical case of multiple injuries is reported in which practically complete chemolitholysis has been achieved by combined oral and local therapy. The rapid growth of the calculi and their alarming tendency to recurrence in case of inadequate treatment is emphasized. The therapeutic method used in this case is regarded as suitable for practical purposes.

Administration, Oral↗
PubMed1982

Pyelonephritis in pregnancy: its role in the production of maternal infective calculi and infantile pyelonephritis.

A review of 910 cases is presented, with regard to the late consequences of pyelonephritis in pregnancy affecting both the mother and the child. Late recurrences of pyelonephritis in the mother and pyelonephritis in the child have been likewise registered. According to statistical figures, pyelonephritis in pregnancy greatly increases the hazard of calculus formation. The necessity for a long-term follow-up of mother and child after pyelonephritis in pregnancy is stressed. The significance of the measures to be taken in case of asymptomatic bacteriuria is pointed out.

Female↗