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Biomedical subjects

J Hałuszka

Publications and source records attributed to J Hałuszka.

13 recordsLinked to original sources

[Evaluation of the bronchodilatory activity of berodual and its components: fenoterol and ipratropium bromide in children with bronchial asthma].

The bronchodilatory activity of Berodual in comparison to Fenoterol and Ipratropium Bromide was investigated in a group of 59 children aged 8-15 years, suffering from mild bronchial asthma in a symptoms-free period. The relaxing activity was monitored dynamically by means of the analysis of flow-volume curve measurements. We have found that the bronchodilatory activity of Berodual was faster, stronger and longer in comparison to Fenoterol and Ipratropium Bromide.

Adolescent

[Standards in evaluating the test of obstruction reversibility based on the flow-volume curves].

The study analyzed the changes in the shape of the flow-volume curve after fenoterol (Berotec) inhalation in school age healthy children. Significant increase of FEF25-75%, FEF50%, FEF25% values were seen. The authors demonstrated that bronchodilatation was not related to sex, height, weight and children's age, but it's value is indirectly proportional to the at-rest state of the airways. It seems, basing on results of this study, that FEV1 and FEF25-75% are the best indexes of dilatation tests. Increases of 10% and 30% are significant of bronchodilatation.

Adolescent

[Computer-assisted calibration of inductive plethysmography].

A software program was written assisting calibration and measurement of the inductive plethysmography RESPITRACE. In 6 subjects calibration was carried out using both methods and a confirmation was found in the 20% area of dispersion. The use of only one measuring tape enables a very precise measurement of ventilation.

Adult

[Results of immunotherapy with HDM (Bencard) in children with bronchial asthma].

Desensitization with HDM manufactured by Bencard was carried out in a group of 20 children with bronchial asthma showing hypersensitivity to Dermatophagoides pteronyssimus allergen in prick skin tests. Ten randomly selected children treated symptomatically and with climate served as a control group. Children were examined clinically before and after desensitization. Clinical improvement was observed 15 months after desensitization together with weakened delayed bronchial response to allergen inhalation. No significant difference in patency of airway was seen in both groups. Differences in serum IgE and IgG levels and mean eosinophilia in the peripheral blood were statistically insignificant.

Ascorbic Acid

Decrease of complement hemolytic activity after an allergen-house dust-bronchial provocation test.

Twenty-two children with bronchial asthma and positive skin tests to house-dust allergen were subjected to a bronchial provocation test with the allergen, and both bronchial reactions and serum complement hemolytic activity were measured at different intervals after the challenge. Changes in complement hemolytic activity did not correspond either with early or late bronchial reaction to the allergen. A reproducible drop in complement hemolytic activity after allergen challenge was observed in eight patients and could be prevented in four out of seven patients by sodium cromoglycate. The duration of early bronchial obstructive reaction was longer in tests where parallel complement changes were observed.

Adolescent

Lung function of children with history of obstructive bronchitis in their infancy.

A group of 98 children admitted to the hospital in the first 2 years of life with diagnosis of obstructive bronchitis was reexamined at 10 years of age. The examination included complexed lung function measurements. No important functional abnormalities were found in relation to passed obstructive bronchitis, features of allergy, frequency of attacks of the disease in the past, and bronchial reactivity to histamine. In the small group of children with diagnosis of bronchial asthma in the meantime made, the results of examination were most frequently abnormal but did not coincide with the previous diagnosis. They indicated rather nonhomogeneity of ventilation, characteristic for peripheral lung abnormalities.

Bronchitis

[Efficacy of gas exchange in the lung of children (author's transl)].

Determination of the CO transfer through lungs is the most direct method of determination of lung function. In children more convenient for practical use is the "steady state" than the "single breath" method. Besides classical coefficient of transfer (TLCO) interpretation of results may be widened by coefficients of the CO fractional uptake - global (FUCO) and partials, informing about exchange of gases in airways (FUCO) and in alveolies (FUaCO) the predicted values of the above coefficients should be calculated, accordingly to the opinion of authors, in relation with tidal volume (TV) or with total lung capacity (TLC), but FUCO and FUaCO with frequency of breathing (f). Cited examples of clinical results prove practical usefulness of application the "steady state" method in children.

Adolescent

Proteins in bronchial secretion of children with chronic pulmonary diseases. I. Relation to clinical diagnosis.

Bronchial secretions from 207 children suffering from various pulmonary diseases and from 15 healthy controls were tested concentration of IgA, IgG, lactoferrin and lysozyme. The results obtained suggest that in many cases of chronic lung diseases in children the levels of lactoferrin and immunoglobulins, especially secretory IgA, are very low. In severe infections (cystic fibrosis, bronchiectases) significant increase of IgG concentration was observed.

Adolescent

Importance of respiratory allergy in provoking reversible bronchial obstruction.

In five groups of children: representative sample of normal population, children suffering from bronchitis in the past and children with diagnosed asthmatics, results of unspecific bronchial reactivity to histamine were evaluated and in some of the groups results of skin and inhalatory reactions to allergen solutions were compared. Important discrepancy between skin and inhalatory reactions was shown. Potentialization of unspecific bronchial hyperreactivity after history of bronchitis was noticed. No relationship between attacks of bronchitis in the first 12 months of life and respiratory allergization could be found.

Aerosols