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Biomedical subjects

J Haahr

Publications and source records attributed to J Haahr.

At least 19 recordsLinked to original sources
PubMed2000

[Infantile hypertrophic pyloric stenosis. Decreasing incidence].

The aim of this study was to confirm a clinical suspicion that the frequency of this disease is in decline. A retrospective review of case notes of all children admitted and operated in all hospitals in Viborg County during the period of 1.1.1973 to 31.12.1997 was performed. The local survey was supplemented with a national survey. One hundred and forty-seven patients from Viborg County were operated for infantile hypertrophic pyloric stenosis during the period described. Divided into five year periods the number per 1000 living births was consecutively 1.6, 2.4, 2.0, 2.8 and 0.9. The same tendency was found nationally, Table 1. The decrease started in 1993 and has since strengthened. The reason is unknown, but there is a relation regarding to the timing of a change in recommendations concerning positioning of infants during sleep. However, a causal relation is unknown.

Denmark↗
PubMed2000

Infantile hypertrophic pyloric stenosis. Decreasing incidence.

INTRODUCTION: The study aimed to prove or disprove a clinical suspicion of a decreasing frequency of pyloric stenosis. METHOD: Retrospective review of hospital records of all children operated for pyloric stenosis in the hospitals of the County of Viborg from 1 January 1973 to 31 December 1997. This regional review was supplemented by a nationwide study, in which the National Registry of Patients was searched for the diagnosis number and the operation code of pyloric stenosis during the period 1 January 1977 to 31 December 1997. RESULTS: One hundred and forty-seven children were operated for infantile hypertrophic pyloric stenosis in Viborg County during the period in question. When calculated in five-year periods, the respective numbers per 1000 liveborn children were: 1.6, 2.4, 2.0, 2.8, and 0.9. Only one child was operated per year during 1996 and 1997, compared with an average of seven children annually during the preceding 20 years. The same tendency was found in the nationwide study. Until 1993 an average of 160 children were operated per year, i.e. 2.2 to 3.2 per 1000 liveborn children. From 1993-1997 inclusive the number decreased to 1.4. In 1996 and 1997, respectively, 75 and 76 children were operated, i.e. 1.1 per 1000 liveborn children. CONCLUSION: There has been a significant decrease in the incidence of children with infantile hypertrophic pyloric stenosis, both in the County of Viborg and in the whole of Denmark. The decrease, which started in 1993, has for unknown reasons continued to accelerate ever since. The decrease coincides with changing recommendations concerning the positioning of infants during sleep, but a causal connection is uncertain.

Denmark↗
PubMed1994

[Prognosis of children with very low birth weight in the county of Viborg. A follow-up of an unselected patient group].

Neonatal mortality and follow-up examination among children with birthweight < or = 1500 g born in the period 1983-1987 inclusive has been recorded in an unselected material from a Danish county (Viborg County). There were 100 with birthweight < or = 1500 g and the low-birthweight rate was 7/1000. The neonatal survival was 72% dispersed with 32% for children with birthweight < or = 1000 g and 90% for children with birthweight 1001-1500 g. Four children died before follow-up examination. Of the surviving 68 children 66 were examined between the ages 21 months to six and a half years, the average age being about three years. The test-results were based on a questionnaire to the parents, an objective examination including neuropaediatric assessment and a Denver developmental screening test. Seven children were found to have moderate to severe handicaps, equal to 10% of surviving children. Of these seven children, three (4.5%) have cerebral paresis. Five other children were found to have small "handicaps". In conclusion 12 children or 18% had varying degrees of disability while 54 children were without demonstrable disability at follow up examination.

Child↗
PubMed1981

Thyroxine-binding globulin deficiency in early childhood. Postnatal changes in serum concentrations of thyroid hormones and thyroid hormone-binding proteins.

Serial determinations of serum thyroxine (T4), triiodothyronine (T3), thyrotropin (TSH), thyroid hormone-binding globulin (TBG), prealbumin (TBPA) and albumin were performed in a euthyroid girl with TBG deficiency and in her mother for a period of 22 months after delivery. At 8 days old the child had a serum TBG concentration around 50% of normal level which remained essentially unchanged during infancy. Total serum T4 and T3 concentrations were low, the free serum T4, free serum T3 and serum TSH concentrations were normal. The mother had received thyroid hormone from the age of 15 years. Her serum TBG level at 6 weeks post partum was similar to that of non-pregnant adults but decreased to about 50% of normal level, indicating a TBG deficiency. She remained euthyroid after withdrawal of T4 therapy. Serum TBPA and albumin concentration were normal in mother and child. An X-linked inheritance of the TBG deficiency was suggested from a study of the family.

Adult↗
PubMed1979

Fragile site long arm chromosome 16.

A fragile site at the long arms (q21) of chromosome 16 was found in two persons, each of whom became the parent of a child with a de novo structural chromosome abnormality--a balanced autosomal translocation and an autosomal deletion. The question of an increased risk of structural chromosome abnormalities in the offspring of persons with fragile site long arm 16 is discussed.

Abnormalities, Multiple↗
PubMed1975

Prevalence of Edwards' syndrome. Clustering and seasonal variation?

The incidence of Edwards' syndrome was found to be 1 per 4857 newborn children of 34000 consecutively newborn children in two Danish counties. Six of the 7 cases were born during the months of February through April. The incidence was high compared with the expected incidence of Edwards' syndrome of approximately 1 per 10000. This might be due to clustering in the area studied during the period 1967 to 1973. The finding of variations in incidence of children with Edwards' syndrome in different parts of the world, as well as the finding of seasonal variation in birth of such children, indicates that some of the etiological factors of nondisjunction of chromosome 18 are of an environmental nature.

Abnormalities, Multiple↗