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Biomedical subjects

J Hahn-Pedersen

Publications and source records attributed to J Hahn-Pedersen.

17 recordsLinked to original sources

Varicocele testis evaluated by CT-scanning.

To evaluate and depict CT-scanning of the spermatic cord in seven men with varicocele testis, during quiet breathing and during Valsalva's manoeuvre. With the patients supine, two transverse scans were made during quiet breathing and two with the intra-abdominal pressure increased by a Valsalva manoeuvre. The transsectional area of the spermatic cord varied between 80 and 100 mm2 on the normal sides and between 100 and 200 mm2 on the affected sides. Raised intra-abdominal pressure dilated the veins of the pampiniform plexus, increasing the trans-sectional area by 40-80% on the normal sides and by 100 to 200% on the affected sides. A spermatic cord area as measured at the root of the scrotum of more than 100 mm2 without raised intra-abdominal pressure, and more than 200 mm2 with, signals a varicocele. CT-scanning with raised intra-abdominal pressure can be used as a safe and non-invasive method to detect a varicocele testis and to show its proximal extension into the inguinal canal. We would also recommend this investigation in patients with unexplained groin pain.

Adult↗

Evaluation of direct and indirect inguinal hernia by computed tomography.

The importance of venous distension of the pampiniform plexus in the prevention of inguinal hernia was evaluated. Functional closure of the inguinal canal was investigated by computed tomography during a Valsalva manoeuvre in a normal individual and 12 men with unilateral inguinal herniation, one of whom had previously undergone herniorrhaphy. Thus, 13 normal canals were evaluated along with five with direct and seven with indirect hernia. In all normal canals a rise in intra-abdominal pressure increased the cross-sectional area of the part of the pampiniform plexus located in the medial end of the canal, thereby filling the empty space and preventing herniation. In the lateral part the plexus was compressed against the external aponeurosis by the fascia transversalis in a valve-like fashion. In cases of direct inguinal herniation the distended pampiniform plexus was displaced by the hernia sac during the Valsalva manoeuvre, but in indirect hernia impaired swelling of the pampiniform plexus was seen. It is suggested that this observation could help to explain the normal mechanism of closure of the inguinal canal.

Adult↗

[Factors determining the development of wound infection after appendectomy].

In order to illustrate which factors are of significance for the development of wound infection after appendectomy, an extensive prospective material of 2,097 patients submitted to appendectomy was analysed. Regression analyses demonstrated that age alone, employment of preoperative antibiotics (cefoxitin) and patient delay (time from onset of symptoms till admission) were of significance. The present authors conclude, on the basis of this material, that all patients over 25 years of age should be given preoperative antibiotic prophylaxis which covers aerobic and also anaerobic microorganisms. If a gangrenous or perforated appendix is found, antibiotics should be administered intraoperatively if prophylactic treatment has not been administered. In cases of perforation, antibiotics should be administered postoperatively for 72 hours.

Adolescent↗

Functional closure of the femoral canal revealed by computed tomographic scanning.

The lacuna vasorum contains, as well as the external iliac vessels, a space called the femoral canal which allows pulsation and other changes in the diameter of the two vessels. The canal is closed by a connective tissue septum which is too weak to prevent a herniation alongside the vessels. The functional closure of the canal was investigated by artificial augmentation of the intraluminal pressure of the vein in five specimens and by computed tomographic (CT) scanning during a Valsalva manoeuvre in ten normal persons. In the abdomen the intraluminal and extraluminal pressures are raised in parallel, with no consequence for the diameter of the vessels. In the area of the lacuna vasorum the intravenous pressure is conveyed down to the first competent valve which is located 0.5 cm distal to the inguinal ligament, while the extraluminal pressure is reduced to normal. At each rise of the intra-abdominal pressure the vein will therefore bulge and exactly fill the empty space of the femoral canal thus preventing herniations by an on-demand mechanism. By CT scanning it was found that the vein in the femoral canal increased its diameter 2.5-3.0 times during the Valsalva manoeuvre.

Abdomen↗

Antibiotic prophylaxis in acute nonperforated appendicitis. The Danish Multicenter Study Group III.

In a prospective, block-randomized, multicenter study, the safety and efficacy of cefoxitin in preoperative prophylaxis were studied. 1735 patients undergoing appendectomy were evaluable, and half of these patients received 2 g of cefoxitin before undergoing operation. The patients were divided into three groups: patients with a normal appendix, patients with an acutely inflamed appendix, and patients with a gangrenous appendix. The study showed for each group a significant reduction of the incidence of wound infection in patients receiving prophylaxis. However, intra-abdominal abscess formation was not influenced by preoperative antibiotic prophylaxis. Consequently, routine preoperative prophylaxis is recommended before appendectomy.

Abdomen↗

Hydrometrocolpos: current views on pathogenesis and management.

Hydrometrocolpos usually occurs in the neonatal period. The majority of cases are caused by vaginal occlusion by a transverse septum combined with cervical secretion. Although not well appreciated genital distension by urine may occur in some cases with a persistent urogenital sinus or cloaca. We report 3 cases of urinary and 8 cases of secretory hydrometrocolpos. The frequency of associated anomalies, especially in the urogenital tract, was high (9 of 11 patients), which was the most important factor in determining the morbidity and mortality. Of the patients 2 died, and 9 are alive and healthy, demonstrating that the prognosis of hydrometrocolpos is excellent. The diagnosis of hydrometrocolpos should no longer be difficult to determine. The most important step is a thorough vaginal examination, although modern imaging methods may be helpful. The aim of treatment is distal vaginal drainage, which can be achieved by a perineal procedure in most cases. Laparotomy is indicated only in cases of high vaginal atresia, which require a vaginal pull-through procedure.

Abnormalities, Multiple↗

Supernumerary ovary.

A case of supernumerary ovary is reported--the eleventh in the literature. The patient had two left-sided ovaries, associated with contralateral hemiuterus.

Abnormalities, Multiple↗

Portographic findings and coagulopathy in cirrhosis.

Percutaneous transhepatic portography was performed in 57 patients with cirrhosis and portal hypertension. The portographic findings, the free portal pressure and the coagulation tests were analyzed. Moderate or severe abnormality of the coagulation system was significantly associated with extrahepatic shunting, large gastric varices and collaterals from the splenic vein and splenic hilum. Reduced levels of prothrombin, factor X and thrombocyte counts were the factors mainly accounting for this association. As severe variceal bleeding is associated with these changes in the portal circulation, identification of patients at high risk may be based on portography combined with examination of the coagulation system.

Adult↗

Improvement in quality of life following jejunoileal bypass surgery for obesity.

Psychological and physical adaptation to jejunoileal bypass surgery for obesity was evaluated in 55 patients observed 15 months to 6 1/2 years postoperatively after a weight loss of about 50 Kg. The response to weight loss, as assessed by a comprehensive, structured questionnaire was an improvement in working capacity, interpersonal relationship, leisure time activity and adjustment to daily life. Sexual activity improved, particularly in men, and irregular menstruation normalized. Body image improved. Major postoperative psychiatric complications were not seen, which may be due to meticulous selection of the proper patients.

Adaptation, Physiological↗