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Biomedical subjects

J Hamels

Publications and source records attributed to J Hamels.

33 records · Page 2Linked to original sources

Atypical lymphohistiocytic bone tumour (osseous variant of Rosai-Dorfman disease?).

A single osteolytic bone tumour with a cellular composition similar to that of the extra-nodal localization of Sinus Histiocytosis with Massive Lymphadenopathy although with greater cellular atypicality is described. This histological similarity suggests the possible occurrence of isolated bone involvement of Rosai-Dorfman disease, with atypical cytology but benign evolution, which has not been reported in the literature.

Bone Neoplasms↗

Remission of Goodpasture's syndrome after withdrawal of an unusual toxic.

A 19 year old girl working as a hairdresser developed a severe anemia due to occult pulmonary hemorrhage followed by anti-GBM glomerulonephritis with normal renal function. Withdrawal of the suspected toxic factor, products used for permanent waving, was followed by both clinical remission and disappearance of linear deposits of immunoglobin from the renal glomeruli. Anti-GBM antibodies were only detected in the serum after clinical healing. In a case of mild Goodpasture, careful search for a toxin and its withdrawal may be the first therapeutic step.

Adult↗

Unusual aspects of synovial chondromatosis of the elbow.

A 60-year-old man suffered locally from a rather aggressive chondromatosis of the elbow. Clinically the presentation was rather uncommon, with some radiological aspects (juxta-articular bone rarefaction) differing from those of ordinary chondromatosis. Neither the pathologist nor the radiologist recognized signs of malignancy. Regional osteoporosis, although rarely described in synovial chondromatosis, was considered as the diagnosis in this patient, but a low grade primitive chondrosarcoma must be sought in such cases.

Bone Neoplasms↗

[Osteoarthritis and tenosynovitis of the finger due to Mycobacterium intracellulare. A case report and review of the literature].

The authors present one case of osteo-arthritis and tenosynovitis of the right forefinger due to Mycobacterium intracellulare, in a 61-year old woman. The treatment consists of a synovectomy of the finger's proximal interphalangeal joint and of the sheath of the flexor tendons and a drug regimen associating erythromycin and cotrimoxazole for 2 1/2 months. This therapy proves successful, as the patient is clinically cured. A literature review records 19 similar osteo-articular and peri-articular infections due to the Mycobacterium avium-intracellulare group, reported during these last 25 years.

Arthritis, Infectious↗

[Genital actinomycosis and the intrauterine device. Apropos of 3 cases].

Three cases of actinomycosis are reported. In two of these three patients, both of whom had worn an intra-uterine device for several years, the actinomycosis probably followed secondary to previous appendicitis. In the third case, however, it was primary and directly linked to the presence of the I.U.D. From these observations and from studying the literature, this type of infection should be suspected in any women wearing an I.U.D. who has a tubo-ovarian abscess.

Abscess↗

The histiocytic nature of dermatofibrosarcoma protuberans. Tissue culture and electron microscopic study.

Specimens from four cases of dermatofibrosarcoma protuberans when explanted in vitro exhibited a typical ameboid outgrowth, confirming the histiocytic nature of these tumors. The cultures displayed the same evolution from macrophages to fibroblast-like cells observed previously in cultures of other types of histiocytomas. Electron microscopic study of the cultures confirmed the light microscopic findings and suggested that the fibroblast-like cells were histiocytes with some secondarily acquired fibroblastic features. The possibility that neoplastic histiocytes may transform into true fibroblasts was deemed unlikely, but could not be excluded.

Adult↗

Angioimmunoblastic lymphadenopathy following ciprofloxacin administration.

Angioimmunoblastic lymphadenopathy (AILD) is a rare disorder characterised by generalised lymphadenopathy, fever, hepatosplenomegaly, immune hemolytic anemia and polyclonal hypergammaglobulinemia. We report the occurrence of histology-proven AILD in a patient who had received ciprofloxacin. We suggest that this drug may be added to the list of agents susceptible to elicit AILD.

Aged↗

Complicated Meckel's diverticulum diagnosed preoperatively in three cases by complementing CT with detailed us studies.

The clinical and imaging features of Meckel's diverticulum of the adult are reviewed through the report of three complicated cases, one presenting with perforation, the second with intestinal bleeding, and the third with intestinal occlusion due to phytobezoar impaction. Intradiverticular heterotopy of gastric mucosa was the responsible common denominator for the first two cases. Intradiverticular calcified entheroliths were also found in the second case. Obstruction due to a phytobezoar as observed in the third case is a very rare presentation. This report clearly emphasizes and encourages the approach of this difficult diagnosis by combined CT and US imaging.

Adult↗