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Biomedical subjects

J Handberg

Publications and source records attributed to J Handberg.

5 recordsLinked to original sources
PubMed1996

[High-dose chemotherapy and autologous bone marrow transplantation in solid tumors. A review].

This review deals with high-dose chemotherapy plus haematopoietic stem cell support as treatment to patients with chemosensitive solid tumours, breast-, testicular-, small cell lung-, and ovarian cancer. Dose-intensification of cytotoxic agents without stem cell support has not increased survival in these patients. High-dose chemotherapy plus stem cell support is a promising treatment strategy as adjuvant therapy in patients with high-risk breast cancer, i.e. more than 6-10 metastatic axillary lymph nodes, and there are several on-going randomized studies investigating conventional versus high-dose therapy in this situation both in Europe and in the US. Another international randomized study concerns patients with testicular cancer, where high-dose therapy is given as relapse treatment and as initial therapy in high-risk patients. High-dose therapy is an experimental treatment in all solid tumours, but there are no data supporting randomized studies in other solid tumours.

Antineoplastic Agents↗
PubMed1993

[Acute suppurative thyroiditis].

A woman aged 54 years with acute suppurative thyroiditis is described. The patient had a well-known non-toxic diffuse goitre with a cyst in the left lobe. She was treated with levothyroxine (Eltroxin) for three years before actual hospitalization. Four weeks previously she had been treated with sulphamethizole for a bladder infection. Antibiotic treatment, surgical drainage and, finally, lobectomy of the left thyroid lobe cured the patient, including regression of paraesthesia in the left arm. E. coli was found in urine, blood and pus bonum from the abscess.

Acute Disease↗
PubMed1993

[Purulent meningitis among adults in the county of Frederiksborg. Therapeutic results in the period 1 January 1980--31 December 1990].

A review of 158 cases of bacterial meningitis and meningococcal sepsis in adults is presented. The patients were admitted during a 11-year period, from 1980-1990. The incidence was 5.5/100,000 adults per year, which is high. The area had epidemics of meningococcal disease in the years 1987 and 1989. The bacterial agent was meningococci in 40.5%, pneumococci in 21.5% and unknown in 27.2%. The overall lethality was 13.9%, highest (26%) in patients who were infected by pneumococci. The meningococcal relative lethality was 14%. In the period of high meningococcal incidence 1986-1989, we found a relative lethality of 17%. The overall local hospital lethality was 18.3%, which has to be compared with 11.2% among patients primarily admitted to the County hospital. The lethality among patients who underwent emergency transfer from one of the local hospitals to the County hospital was 20%, which is as high as in the group of patients treated locally. Neither of these trends lethality are statistically significant at the level of 5%, tested by chi square tests.

Adolescent↗