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J Hanlon

Publications and source records attributed to J Hanlon.

29 records · Page 2Linked to original sources
PubMed1987

Neuroleptic-induced neutropenia in the elderly.

A case reported here of Haloperidol-induced neutropenia demonstrates one of many important drug reactions to which the elderly may be predisposed. Neuroleptics can lead to neutropenia by toxic or immunologic mechanisms, and it is impossible to predict which patients will sustain this potentially life-threatening reaction. Fever and infection may be the only clue to this blood dyscrasias. The diagnosis of drug-induced neutropenia is largely one of exclusion coupled with the observation of increasing neutrophil counts after cessation of the drug.

Aged↗
PubMed1978

Correlation of antitumor chemoimmunotherapy with serum inhibition of tumor cell destruction.

The administration of cyclophosphamide and Corynebacterium parvum in combination results in tumor growth inhibition greater than that resulting from the use of either agent alone. The precise mechanism(s) by which this chemoimmunotherapy combination results in a synergistic inhibiting effect is not known. The possibility was entertained that the tumor effect might be related to a greater decrease in serum-mediated interference with cellular cytotoxicity, i.e., "blocking" activity, by both agents in combination rather than by either alone. The present findings fail to support such an explanation. C. parvum by itself failed to decrease serum inhibition and in conjunction with cyclophosphamide resulted in an effect that was no greater than that produced by cyclophosphamide alone.

Animals↗