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Biomedical subjects

J Hanzlik

Publications and source records attributed to J Hanzlik.

At least 19 recordsLinked to original sources
PubMed1992

Atherosclerosis risk factors in the inhabitants of the nascent Coal Basin of Lublin region.

There were examined 222 men and 253 women over 18 years of age, selected at random from among country people living in the area of the nascent Coal Basin of Lublin district. There was determined their height and body weight, degree of overweight, general fat content in the body, arterial systolic and diastolic blood pressure as well as blood serum cholesterol concentration, concentration of triglicerides, glucose and uric acid in the blood. It was found out that the level of studied vascular atherosclerosis risk factors in the population under study was lower than the level found by the Polish Experiment in other populations.

Adult↗
PubMed1992

[Reference values of selected parameters of lung functions in the population of Bogdanka coal miners].

The aim of the study was to construct and test new equations for calculating FEV1, ITGV and FVC predictive values. Our examined population consisted of 2058 coal miners working underground in Bogdanka colliery (Lublin Basin). The following persons were excluded from out considerations: 1. smokers, 2. miners with pulmonary or allergic diseases history, 3. patients with chronic cough, sputum production or symptoms of chronic rhinitis, 4. persons with bronchial hyperreactivity. Finally, our standard group consisted of 353 coal miners. On the basis of our standard group data, new equations for calculating predictive values were formulated using the multiple regression model. According to these new equations and to equations elaborated by other authors, we calculated predictive values for FEV1, FVC and ITGV in our standard population and expressed results of measurements in percentages of different predictive values. Our predictive values in the standard population were significantly higher than the other authors' values. Percentages of predicted values were lower in the same comparison. We believe that observed differences are linked to a possible self-selection phenomenon in occupationally exposed population, relatively small maximum age of our standard group, possible differences in anthropometric features among examined populations and excluding hyperreactives. Our results seem to emphasize the need of greater attention to the paid on more restrictive use of the specially formulated equations in separate age compartments.

Adult↗
PubMed1992

[Unfavorable blood lipid indicators in obesity].

There were evaluated total serum cholesterol, cholesterol HDL, cholesterol LDL and triglycerides in relation to relative body weight, calculated according to Broca-Broughs formula and changes in body weight during last 5 years in 306 males aged 40-59 from the housing estate "Czechow" in Lublin. Mean total cholesterol, cholesterol LDL and triglycerides concentration were higher and cholesterol HDL was lower in overweight males in comparison with normal weight subjects. Significantly higher mean triglycerides concentration was stated in becoming overweight as compared with stable weight males.

Adult↗
PubMed1990

[Risk factors of coronary artery disease in males during a 3 year follow up based on a cohort study in a selected region of Lublin].

To assess changes in risk factors of coronary artery disease, examinations which had been performed in 1981 and 1982 were repeated in males aged 40-59, inhabitants of the district "Czechów" in Lublin. The study was based on Polish Experiment of Coronary Disease Multifactor Prevention assumptions 112 of 203 males investigated in 1981, 1982 underwent repeated examination (attendance rate - 55%). Statistical analysis was performed only in twice examined subjects. Significant increase of blood pressure, body weight, total serum cholesterol and uric acid concentration was stated in comparison with their respective initial values. Significant decrease of HDL-cholesterol and no changes in serum triglycerides concentration were observed. The only positive stated alteration was a lower percentage of tobacco smokers. Diagnosis of coronary artery disease remained unchanged despite of increased risk factors levels (increase of mean Rose's index score from 5 in initial examination to 6.5 in a control one). This high increase in risk factors occurrence allows an unfavourable prognosis for future incidence of coronary artery disease and also demands to undertake vigorous prevention.

Adult↗
PubMed1989

Shock in patients treated in the General Clinic of Internal Diseases, the Medical Academy in Lublin in the years 1979-1988.

Shock is, as before, among one of the most serious pathologic states threatening patient's life in spite of considerable progress in its treatment in the recent ten years. The immediate causes of shock may be a decrease of cardiac output, increase of volume of vascular bed or interaction of them both. Decrease of cardiac output may result from defective heart ability to contract or decrease venous blood flow to the heart. Decrease of stroke volume and cardiac output result in defective blood flow through all tissues and lead to metabolic acidosis, whose intensity is decisive for prognosis.

Adult↗
PubMed1989

[Prevalence of coronary disease risk factors in the male population 40-59 years of age from the housing complex "Czechów" in Lublin].

There was studied randomly selected approximately 10% sample of population of males aged 40-59 from the housing estate "Czechów" in Lublin. Authors assessed the level of coronary artery disease (CAD) basic risk factors as well as a percentage of persons with a high risk of developing CAD. The study was extended by determinations of plasma HDL--cholesterol, glucose and uric acid concentrations. Mean total cholesterol concentration (220.4 mg/dl) as well as the frequency of hipercholesterolemia occurrence (15.4%) were significantly higher in comparison with their values in male populations of Warsaw and Southern Poland. Mean systolic (134.2 mm Hg) and diastolic (87 mm Hg) blood pressures as well as frequency of hypertension occurrence (22.7%) were comparable with results of two, above mentioned, epidemiological studies. We stated the lower percentage of current tobacco smokers (52.2%). The overweight of 115% or more was stated in 22.2% of persons. Very high percentage of men of low physical activity was stated (51%). Higher level of respective risk factors reflected in individual score of CAD risk coefficient fixed on 5 points and being higher than in other studies of different Poland regions populations.

Adult↗
PubMed1989

[Content of overall fat in the body and levels of selected coronary risk factors].

Authors estimated total adipose mass based on skinfold measurements in 205 males aged 40-59, residents of the housing estate "Czechów" in Lublin. They studied the correlations among calculated total adipose mass and arterial blood pressure as well as serum lipids levels. It was stated, that total adipose mass of the examined group was similar with those of other urban males populations. Total adipose mass well correlated with arterial blood pressure and serum triglycerides levels, but poorly with total serum cholesterol concentrations. Greatly significant inverse correlation between total body adipose mass and a concentration as well as a percentage of HDL-cholesterol was proved.

Adult↗
PubMed1986

ApoA-I related DNA polymorphism in humans with coronary heart disease.

A genetic analysis of atherosclerotic patients as well as healthy subjects using an apoA-I gene specific probe confirmed that an EcoRI restriction fragment length polymorphism is related to the development of atherosclerosis. Three subjects with severe coronary heart disease were found to be homozygous for a 6.5 kb fragment hybridizing to the apoA-I probe. In the atherosclerotic patient group 44% were heterozygous for this fragment, compared to 9.5% in the control group. The distribution of genotypes in the atherosclerotic and control groups was significantly different. Among the heterozygous subjects, specific differences were found after digestion of their DNA with Bam HI restriction endonuclease.

Adult↗