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Biomedical subjects

J Hardison

Publications and source records attributed to J Hardison.

3 recordsLinked to original sources
PubMed2001

Inhibition of human multidrug resistance P-glycoprotein 1 by analogues of a potent delta-opioid antagonist.

Analogues Dmt-Tic (2',6'-dimethyl-L-tyrosine-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) pharmacophore, a potent delta-opioid receptor antagonist, inhibited hMDR1 P-GP expressed in a G-185 fibroblast cell line in a manner similar to verapamil. N,N(Me)2-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-NH-1-adamantane, H-Dmt-Tic-Ala-NH-1-adamantane and N,N(Me)2-Dmt-Tic-NH-tBut were highly effective inhibitors. Weaker inhibition was observed with N,N(Et)2-Dmt-Tic-OH, H-Dmt-Tic-Ala-NH-tert-butyl amide and cyclo(Dmt-Tic). Results demonstrate that N- and C-terminal hydrophobic/lipophilic analogues of the Dmt-Tic pharmacophore inhibit hMDR1 and point to a potential role as chemosensitizing agents in chemotherapy for cancers containing hMDR1.

3T3 Cells↗
PubMed1982

Echocardiography in patients with suspected cor pulmonale.

Echocardiography was used to evaluate left ventricular function in 43 consecutive patients with suspected cor pulmonale who clinically had no other heart disease or hypertension. Adequate echocardiographic evidence was obtained by either standard left parasternal position or subxiphoid position in 40 patients (93%). Echocardiographic evidence of either dilatation of the left ventricular cavity or thickening of the right ventricular free wall was present in 37 patients (93%). Small left ventricular end-diastolic cavities suggested that many of these patients had functional left ventricle volume depletion. Echocardiographic evidence of left ventricular dysfunction was present in only three patients (8%).

Adult↗