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Biomedical subjects

J Hartmann

Publications and source records attributed to J Hartmann.

At least 73 records · Page 4Linked to original sources
PubMed1994

Diversity of ethnic and racial VNTR RFLP fixed-bin frequency distributions.

To examine the impact that intra- and interracial genetic diversities have on VNTR RFLP-fragment-size distributions, a multiracial (East Asian, African American, U.S. Southwest Hispanic, and European Caucasian) and multiethnic (Chinese, Japanese, Korean, and Vietnamese) database has been constructed for the following loci: D1S7, D2S44, D4S139, and D10S28. Homogeneity between samples was examined using the Komologorov-Smirnov two-sample test for RFLP fragment sizes and a log-likelihood test for fixed-bin frequencies with theoretical and Monte Carlo empirical significance levels. Small but significant differences between theoretical and empirical significance-level distributions were observed with both procedures, particularly with the latter. The significance levels of the two types of tests were poorly correlated. Statistically significant differences in fragment-size and fixed-bin distributions were found within and between races, with greater differences occurring between races. Cluster analysis and principal components analysis, using different similarity measures, did not support the hypothesis of greater intra- than interracial diversity, which suggests that ethnic variation can be conservatively estimated by racial variation.

Cluster Analysis↗
PubMed1994

[The effect of different flavophospholipol levels in rabbit feed on the fattening rate of hybrid rabbits].

The present study was designed to evaluate the effects of dietary flavophospholipol ("Bambermycin") levels on the growth performance in 400 hybrid rabbits from weaning at 28 days until slaughter at 74 days of age. The fryers were randomly assigned to one of the four dietary treatments that consisted of either 0, 4, 8 or 16 ppm supplemental flavophospholipol. Each treatment was applied to 100 animals each. Dietary treatments exerted no significant effects on live weight, daily weight gain and feed consumption across the entire fattening period. However, daily weight gains in treated fryers were increased by 2.4% on the average. The only significant treatment effect was found in feed conversion (food/gain) in fryers fed 16 ppm supplementation; kilogram food intake per kilogram weight gain was reduced by 0.16 kg as compared to the control group. Mean feed conversion in treated groups was improved by 3.5% on the average. In addition of flavophospholipol a significantly decreased mortality was observed. It was remarkable, that losses caused by infection in control were exclusively due to infections by Bordetella species, while the treated groups were only caused by Pasteurella species.

Animal Feed↗
PubMed1993

Involvement of transmitter systems in neuropsychiatric diseases.

Normal function of the central nervous system (CNS) requires intact morphology as well as neurotransmission. Diseases of the CNS can become manifest as a sensorimotor deficit or psychic alteration, or both. When observing neuropsychiatric diseases, interaction of different transmitter systems is obvious. Thus, an increase or a decrease of transmitter systems affect each other. Mechanisms of compensation can also lead to alterations in transmitter systems not involved in the pathological process. Parkinson's disease, hyperkinetic movement disorders like ballism and Huntington's chorea, epilepsy and anxiety will be used in this paper as examples of the synergistic action of dopaminergic, peptidergic, glutamatergic, GABAergic and cholinergic neurotransmission. With our knowledge of the functional balance of transmitter systems in the CNS, various pharmacological strategies have been available to intervene in the pathophysiological process. The excitatory or inhibitory quality of the transmitter systems must be considered if such strategies are to be employed. On the other hand, a functional balance between two or more transmitter systems may cause a contrary therapeutic intervention on the opposite side of the balance.

Anxiety Disorders↗
PubMed1993

[Occupational and vocational rehabilitation of psychiatric patients: a control and attribution theory approach to examining the effect of working conditions].

In recent years, work and occupational activity have come to assume a therapeutic orientation in the rehabilitation of persons with mental illness. The study presented addressed the specific ways in which work activities during rehabilitation programme participation may act in a manner conducive to rehabilitation. The findings point to a positive relationship between the opportunities objectively available in the work setting for rehabilitees to influence aversive conditions or occurrences and their work-related subjective well-being. A second step enabled us to show that subjective well-being is determined less by the situation objectively at hand but primarily by the mentally ill rehabilitees' perceptions of influenceability and, hence, the experience of controllability. Further, examination of the rehabilitees' attributional patterns concerning the various control experiences revealed that the extent to which their subjective well-being is affected is mediated cognitively. The findings are discussed in view of their implications for the vocational rehabilitation of persons with mental illness.

Adaptation, Psychological↗
PubMed1992

Reproductive toxicity and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects of single doses on the testis of male rats.

The effects of a single dose of TCDD on the testis were studied in rats. The animals were treated (subcutaneously) once with TCDD doses of 0, 0.5, 1.0, 3.0, 5.0 micrograms/kg body weight. Doses of 3.0 or 5.0 micrograms TCDD/kg reduced the number of spermatids/testis significantly (60% of the controls). Electron microscopic inspection revealed that both doses led to a dissolution on the germinal epithelium. Altered germ cells at all developmental stages occurred in all testes evaluated. Doses of 0.5 or 1.0 micrograms TCDD/kg did not induce any effects in the testis; therefore, under these experimental conditions of single exposure to rats the dose of 1.0 micrograms TCDD/kg can be considered as NOAEL.

Animals↗
PubMed1992

[Thoracic radiographs with the AMBER system. A comparison of the diagnostic image quality of film-screen and storage-phosphor radiographs on the grid-partition stand and the AMBER system].

Since April 1990, chest radiographs in the Mannheim clinic have been performed with a slit technique (Kodak AMBER System). In this study, image quality from conventional film/screen combination and from storage phosphor radiography was compared with that from the AMBER system. Phantoms were used to measure spatial resolution and to determine the detectability of nodules. Image quality affecting various structures within the thorax was evaluated on 200 p.a. and 48 lateral radiographs by three radiologists from Mannheim and four from Berlin. In the retrocardiac, retrodiaphragmatic, mediastinal and peripheral portions the best image quality was obtained by film/screen with the AMBER system. Compared with conventional film/screen images, there was no improvement from the AMBER system within the lung parenchyma. The use of storage phosphor plates with the AMBER system did not lead to any further improvement in image quality.

Evaluation Studies as Topic↗
PubMed1991

The influence of chlorpromazine on the potential-induced shape change of human erythrocyte.

The effect of chlorpromazine (CPZ) on the shape of human erythrocytes with different values of transmembrane potential (TMP) was investigated. The shape of red blood cells with negative values of the TMP remained unchanged after the formation of stomatocytes by chlorpromazine, while cells with positive TMP showed a characteristic time course of shape change during the incubation with CPZ. Experiments with vanadate show that this might be due to a difference in the activity of the phospholipid-translocase at different values of TMP.

Chlorpromazine↗
PubMed1991

Histological, enzymatic and mitochondrial DNA studies in patients with Kearns-Sayre syndrome and chronic progressive external ophthalmoplegia.

Kearns-Sayre syndrome has been associated with large heteroplasmic mitochondrial DNA deletions and morphological alterations at the cytological level. We have measured the activities of different respiratory chain complexes in 3 patients presenting mitochondrial DNA deletions and found no close correlation between gene deletions and enzymatic activities. These data, therefore, point out the importance of analyses at the mitochondrial DNA level in such mitochondrial disorders because gross biochemistry may miss any defect.

Adult↗
PubMed1991

[Naturopathy--definition, importance in the education of physicians and pharmacists].

Recent legislation on licenses for physicians and pharmacists prescribes the teaching of naturopathic methods. This requires a clear definition of the subject, which is given in different ways, all definitions leading to the same result. The essential effect of naturopathic methods is to activate sick persons, i.e. it is--in the strict sense of these words--rehabilitating and preventive. Patients who were instructed by their physician and other therapists can subsequently apply these methods autonomously. To teach naturopathy and its methods is likely to be a good means to help students to develop a better understanding of causality in medicine which, as a result of recent physical knowledge and theses, has become very complex and difficult to comprehend.

Curriculum↗
PubMed1989

Blood pressure reduction in hypertensive-diabetic rats by the somatostatin analog MK-678.

A hypotensive effect of an orally-administered cyclopeptide somatostatin analog, MK-678, has been demonstrated in a hypertensive diabetic rat model. Sustained blood pressure reduction failed to occur when the drug was administered to the spontaneously hypertensive rat. The mechanism of hypotension appears independent of effects on a variety of hormones including insulin, glucagon, growth hormone, and components of the renin-angiotensin system including renin activity, plasma angiotensin converting enzyme, and aldosterone.

Animals↗
PubMed1988

Suppression of experimental tractional retinal detachment by low-dose radiation therapy.

We used a standardized model of traction retinal detachment (TRD) created by cellular membranes in the rabbit to test the effects of low-dose radiation therapy in suppressing TRD. The vitreous and lens were removed from pigmented rabbits, and homologous conjunctival fibroblasts were grown in cell culture. After resolution of postoperative inflammation, 50,000 fibroblasts in 0.1 mL of culture fluid were injected into the vitreous cavity. Ten eyes were maintained as controls. Nineteen eyes received 6 Gy (600 rad) of x-ray irradiation one to three hours after cellular injection. Eyes were monitored weekly for three weeks with indirect ophthalmoscopy. Seven (70%) of ten control eyes developed TRD at one week; no additional TRDs were noted at weeks 2 and 3. Significantly smaller numbers of irradiated eyes developed TRD: at week 1, two (11%) of 19; at week 2, five (28%) of 18; and at week 3, five (29%) of 17.

Animals↗
PubMed1988

Implementing meaningful CME as an essential component in a community hospital quality assurance plan.

The pursuit of high-quality patient care within a community hospital highlights the tenuous relationship between the hospital board and administration on one side and the voluntary medical staff on the other. Craddick describes the need to monitor and improve patient management, the commitment of physicians and administrators to high quality care, and the unfortunate failure of most hospital programs to go beyond paper exercises designed to satisfy the Joint Commission of Accreditation of Hospitals (JCAH). The American College of Surgeons summarizes current methods of monitoring the quality of patient care, and gives four examples of successful programs. The JCAH Manual sets standards for hospitals and medical staffs to achieve. However, thus far no one has described how a hospital's medical staff, board, and administration join forces to implement a comprehensive quality assurance program. This paper presents the experience of one community hospital in dealing with this problem over a two-year period.

Concurrent Review↗
PubMed1988

A system approach to intravenous thrombolysis in acute myocardial infarction in community hospitals: the influence of paramedics.

UNLABELLED: During a 3-year period, intravenous streptokinase (IV STK) was given to 110 consecutive patients ages 34-78 in the course of acute myocardial infarction (AMI) in three community hospitals served by the same paramedic system. 1.5 million units of IV STK was given over 30 minutes. Half of the patients were brought to the hospital by paramedics. The average time from onset of pain to administration of IV STK was 107 minutes in the paramedic group and 182 minutes for the others. Of 110 patients, 98 (89%) showed clinical evidence of reperfusion and 94 of 106 patients (89%) showed angiographic reperfusion. Angiography was performed from 1 to 10 days post-AMI. Mean time to angiography was 6 days for the first 58 patients and 2 days for the last 52 patients. In-hospital mortality was 2 of 110 patients and there was 1 late death at 8 months for an overall 3-year mortality 2.7%. Of 86 patients, 83 (96%) working before their infarct are working now. Of 107 survivors, 96 (90%) are Functional Class I. CONCLUSIONS: (1) IV STK is safely administered in a high percentage of AMI patients. (2) IV STK is safely administered in community hospitals. (3) Paramedics act as an early warning system and allow for earlier treatment than patients presenting without paramedic involvement. (4) Successful coronary reperfusion with IV STK results in low mortality rates and minimizes functional disability. (5) A system-wide approach to reducing time to treatment in AMI may be the most influential factor in affecting morbidity and mortality.

Adult↗
PubMed1988

Memory dysfunction following unilateral transection of the fornix: a hippocampal disconnection syndrome.

This study presents a case with a discrete nondischarging lesion of the left fornix that resulted in a marked anterograde memory deficit that was defined by the same material, modality and methodologically specific features characteristic of unilateral lesions of the hippocampus. Since the fornix is the major efferent pathway of the hippocampus to the mamillary bodies, septal nuclei and anterior thalamic nuclei, this patient could be considered to have a hippocampal disconnection syndrome.

Adult↗