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Biomedical subjects

J Hasen

Publications and source records attributed to J Hasen.

At least 19 recordsLinked to original sources
PubMed1993

rhGM-CSF after allogeneic bone marrow transplantation from unrelated donors: a pilot study of cyclosporine and prednisone as graft-versus-host disease prophylaxis.

Cyclosporine and prednisone were administered as graft-versus-host disease (GVHD) prophylaxis to nine patients undergoing marrow transplant from HLA matched, unrelated donors. RhGM-CSF was administered at a dose of 250 micrograms/m2 daily to all patients. The median day of neutrophil recovery to > or = 500/mm3 was Day 16. Four patients developed Grade II acute GVHD and four developed Grade III acute GVHD. One patient, who survived only 25 days, did not develop GVHD at all. One patient developed systemic infection within the first 28 days after marrow infusion. Comparison of these data to a prior series of patients undergoing bone marrow transplant (BMT) from unrelated donors who were treated with rhGM-CSF along with methotrexate and cyclosporine for GVHD prophylaxis suggests that rhGM-CSF is well-tolerated, neutrophil recovery may be earlier but the severity of GVHD does not appear reduced. Selection of the GVHD prophylaxis regimen may affect the hematopoietic response to cytokine therapy. Further trials with rhGM-CSF in patients undergoing BMT from unrelated donors are required.

Adolescent↗
PubMed1985

Specific prolactin release refractoriness to thyroid-stimulating hormone-releasing factor in an obese infertile man.

A specific PRL unresponsiveness to TSH-releasing factor was uncovered during the workup of an obese man with infertility due to oligozoospermia. Normal PRL responses were demonstrated in response to insulin-induced hypoglycemia, MTC, and sleep. Borderline-low circulating T without elevated baseline LH levels which rose in response to clomiphene citrate and normal LH and FSH responses were noted after LH-RH administration, indicating normal pituitary responsiveness, even though occurring in the presence of hypothalamic dysfunction, affecting pituitary gonadal relations, appears located in the pituitary and limited to a single stimulus: TSH-releasing factor.

Adult↗
PubMed1984

Effect of thyroid releasing hormone on bladder and urethral pressures.

In order to explain the pathophysiology of urinary urgency frequency observed following the administration of thyroid releasing hormone (TRH) during thyroid function testing, simultaneous urethrocystometry was performed in six females before and after TRH administration, and in another five females before and after administration of normal saline (control group). Within a few minutes following TRH administration, a statistically significant and consistent drop in maximal urethral pressure and concomitant sensation of urinary urgency in the absence of significant changes in true detrusor pressure suggested the presence of a reflex neuronally mediated motor component to this sensory effect of urinary urgency. The absence of urethral and detrusor pressure changes in the control group reinforced the TRH-mediated origin of urinary urgency.

Adult↗
PubMed1981

Primary hypogonadism and 13/15 chromosome translocation in Prader-Labhart-Willi syndrome.

A 14-year-old male with Prader-Labhart-Willi syndrome (PLW) had hypogonadism, normal serum gonadotropin levels and 13/15 chromosome translocation. The 24-hour pattern of LH and FSH secretion was normal and comparable to that observed in males at the middle to late stage of puberty. LH rose during sleep and LRH infusion. Basal serum testosterone was low, in the 60-136 ng/dl range, and rose modestly during sleep, LRH and HCG. The 24-hour mean concentrations of androsterone, androsterone sulfate, dehydroepiandrosterone, dehydroepiandrosterone sulfate and prolactin were comparable with normal adolescent males. Biopsy of an undescended testis revealed poor morphology with disorganized spermatogenesis and normal Leydig and Sertoli cells. The 13/15 chromosome aberration was a balanced Robertsonian translocation occurring in his mother and in 5 of 6 siblings, although only the patient had PLW. These data indicate that hypogonadism in PLW is not necessarily hypothalamic-pituitary in origin and that D-chromosome translocations, or deletions per se are not sufficient to explain the etiology of PLW.

Adolescent↗
PubMed1980

Gonadal function in trisomy 21.

Endocrinologic evaluation of 39 patients with trisomy 2 and associated hypogonadism demonstrated elevations of follicle-stimulating hormone and luteinizing hormone; consequently, it can be concluded that both germinal and Leydig cell function are affected. A negative correlation between testicular size and plasma follicle-stimulating hormone was documented. Plasma testosterone levels were found to be normal in male patients as were estradiol levels in female patients with trisomy 21. On the basis of these findings, the simplest and most practical diagnostic approach to evaluate germinal cell function appears to be a single plasma follicle-stimulating hormone determination supplemented by an accurate measurement of testicular volume in males.

Down Syndrome↗
PubMed1978

Endocrine studies in primary hypogonadism.

Two 15-year-old boys with primary hypogonadism had evaluation of their hypothalamic-pituitary-gonadal axis. Testicular biopsies and chromsomal studies were also performed. Both patients presented with delayed puberty and short stature and had prepubertal LH, FSH and testosterone concentrations. Serial 24-hour frequent-interval blood studies over a 2-year period in one patient (R.F.) showed a gradual progression from a normal early pubertal LH secretory pattern to one characteristic of 'primary' testicular failure. The testicular biopsies showed prepubertal tests with no significant germinal cell maturation. Although both patients had some somatic stigmata of Noonan's syndrome, they had different karyotypes (XY and xyq-). These studies show that elevated levels of LH and FSH in primary hypogonadism syndrome may not become apparent until after the onset of CNS puberty.

Adolescent↗
PubMed1978

H-Y antigen: localization of the H-Y gene.

Testicular development in a patient with deletion of the distal (fluorescent) segment of the Y chromosome is described. The presence of a normal dose of H-Y antigen was demonstrated by Goldberg's cytotoxicity test. It is concluded that the distal fluorescent segment of the Y chromosome is void of genes regulating H-Y antigen activity.

Adolescent↗
PubMed1977

Triiodothyronine-producing metastatic follicular thyroid carcinoma.

Thyroid hormone serum concentration was determined in a thyroidectomized patient with functional follicular thyroid carcinoma with metastases. Marked diminution of circulating serum T4 and FT4 with normal T3 serum concentration was found. The clinical implications of this shift in secretory activity are discussed.

Aged↗