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Biomedical subjects

J Hasik

Publications and source records attributed to J Hasik.

At least 19 recordsLinked to original sources
PubMed1987

Seasonal prevention of duodenal ulcer recurrences with pirenzepine.

Seasonal accumulation of duodenal ulcer recurrences suggests that maintenance therapy could be limited to the more risky periods. We carried out a 2-year, multi-centre, randomized, double blind study in 250 patients in whom the last ulcer proved to be healed at the endoscopy on entry. One-hundred-and-twenty-six patients in group A were given pirenzepine 2 X 25 mg while 124 in group B had 2 X 50 mg daily from the beginning of January to the end of March, and from the beginning of September to the end of November for two consecutive years. Test endoscopies were performed each year at the end of February, May and November. Both groups proved to be well comparable. Thirty-five patients dropped out from group A in the first and 10 in the second year; in group B 27 and 29, respectively. As the effect did not show any dose relation, the four yearly cycles were summarized. Recurrence rate checked in May was 22.1% while in both pirenzepine protected months it was 11.3% (p less than 0.0005) and 13.4% (p less than 0.001), respectively. We conclude that pirenzepine administered in the risky seasons prevents the peak ulcer incidence and reduces the recurrence rate to a level lower than in the non-risky season. Thus pirenzepine is effective in ulcer prevention even if administered in an interrupted manner.

Adult↗
PubMed1986

[Clinical and metabolic evaluation of patients with chronic pancreatitis following a special peptide diet].

The purpose of present investigations was to evaluate the effect of peptide diet upon clinical and metabolic course of chronic pancreatitis. Nitrogen, potassium and sodium balances were done for 24 days in 4 patients with chronic pancreatitis fed with peptide diet as well as in 5 patients fed with normal low fat diet. Administration of peptide diet improved protein nutritional status of all patients, due to better absorption of aminoacid components and increased nitrogen retention. On the basis of obtained results the authors discuss possibility of dietary treatment of chronic pancreatitis with peptide diet.

Adult↗
PubMed1979

[Electron microscopic studies in ulcerative colitis].

In 26 patients with the classical clinical picture of an ulcerous colitis and in 8 healthy control persons in the course of a rectoscopy in about 15 cm depth tissue was taken bioptically and underwent an electron-microscopic investigation. Moreover, enzyme-histological examinations were performed. Summarizingly, clear references to immune-pathological processes for development and course of ulcerous colitis are the result.

Biopsy↗