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Biomedical subjects

J Hattab

Publications and source records attributed to J Hattab.

9 recordsLinked to original sources
PubMed1997

Brain fantasies.

Any reasoning concerning the brain must face two different objects: the organ-brain, and the metaphoric-brain. Because we know so little about the true nature of brain/mind relations, we have to be extremely careful and humble when coping with brain and mind. It is necessary above all to make a clear distinction between reality and fantasies, between organ-brain and metaphoric-brain.

Behavior↗
PubMed1995

Ethical issues in biological psychiatric research with children and adolescents.

OBJECTIVE: This article reviews, discusses, and elaborates considerations and recommendations summarized by the biological research working group at the May 1993 NIMH conference on ethical issues in mental health research on children and adolescents. METHOD: Notes from the conference were summarized and supplemented by a computer search of relevant literature. Drafts were circulated for comment to national and international experts, some of whom joined as coauthors. RESULTS: Issues addressed include possible overprotection by policy makers and institutional review boards arising out of the recognition of children's special vulnerability without equal recognition of their need for research; the definition of minimal risk, which has often been equated with no risk in the case of children; assessment of the risk-benefit ratio; procedures for minimization of risk, such as improved technology, "piggybacking" onto clinical tests, and age-appropriate preparation; the difficulty of justifying risk for normal controls; age-graded consent; special considerations about neuroimaging; "coercive" inducement, both material and psychological; disposition of unexpected or unwanted knowledge about individuals, including the subject's right not to know and parent's right not to tell; and socioeconomic status and cultural/ethnic equity. CONCLUSIONS: The working group adopted a position of advocacy for children's right to research access while recognizing that this advocacy must be tempered by thoughtful protections for child and adolescent subjects.

Adolescent↗
PubMed1993

Child psychiatry in Israel: history and trends.

Child psychiatry is a relatively new medical profession in Israel. For many years adult psychiatrists treated children and adolescents without official recognition of the profession. The development of child psychiatry in the medical world, the determination of colleagues and support of outstanding child psychiatrists from abroad (Professors Solnit and Noshpitz) led to the acknowledgment and official recognition of child psychiatry by the Scientific Council of the Israel Medical Association in 1981. Almost all graduates in child and adolescent psychiatry in Israel fill responsible positions and prove the necessity for more child psychiatrists and child psychiatry in the medical and psychiatric system both in hospitals and in the community.

Child↗
PubMed1984

Plasma cyclic AMP and cyclic GMP in childhood-onset psychoses.

Plasma cyclic AMP is a "second messenger" that may reflect levels of activity of important neurotransmitter receptors. Plasma cyclic AMP was measured in 18 patients with childhood autism, 7 patients with pervasive developmental disorder, and 12 age- and sex-matched healthy controls. Plasma cyclic AMP was significantly elevated by over 100% in both groups of patients with childhood-onset psychoses compared with controls. Plasma cyclic GMP, a nucleotide linked to different receptors, was not elevated, suggesting that the finding may be specific.

Adolescent↗
PubMed1978

Plasma dopamine-beta-hydroxylase in childhood psychosis.

A previous report suggested that plasma dopamine-beta-hydroxylase (DBH) is elevated in childhood autism. We measured plasma DBH in 15 Children with functional psychosis and in 10 psychotic children with known organic etiology. DBH activity was significantly elevated in the children with functional psychoses and showed a significant correlation with age that is not reported for this age range in normals. It is possible that children with functional psychoses show an abnormal continuation of the rise in plasma DBH activity characteristic of infancy. No differences between children with functional psychoses and children with organic psychoses were found for red blood cell catechol-O-methyl-transferase, plasma monoamine oxidase, or plasma cyclic AMP.

Adolescent↗