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Biomedical subjects

J Hawiger

Publications and source records attributed to J Hawiger.

101 records · Page 6Linked to original sources
PubMed1967

Staphylococcal clumping with soluble fibrin mmonomer complexes.

Clumping reaction, using standard suspension of Staph. aureus Newman D-2-C strain and various substrates, was quantitatively tested. It has been shown that clumping occurs in fibrin lysate containing soluble fibrin monomer complexes unclottable by thrombin. The reaction was positive with staphylococcal strains possessing clumping factor regardless of staphylocoagulase production. Clumping reaction is similar to paracoagulation reaction induced by protamine sulfate. The substrate for both reactions is stable at 56 degrees C but is destroyed at 60 degrees C. The kinetics of substrate formation for both reactions during fibrin clot lysis is also similar. Clumping reaction with a strain of Staph. epidermidis possessing no clumping factor was positive when these bacteria were coated with protamine sulfate. The effect of heparin, sodium citrate, urea, 2-mercaptoethanol, merthiolate, and mucin on both reactions was tested. The present findings explain the clumping reaction in serum and emphasize the role of blood clotting and fibrinolytic systems in this phenomenon.

Blood Coagulation↗
PubMed1967

Antibiotic sensitivity of Micrococcus radiodurans.

A wild-type strain of Micrococcus radiodurans and its nonpigmented mutant W(1) were tested for sensitivity to 10 antibiotics selected from the standpoint of their mechanism of action. Representatives of groups of antibiotics inhibiting deoxyribonucleic acid (DNA) synthesis, DNA-dependent ribonucleic acid synthesis, protein synthesis, and cell wall synthesis were selected. M. radiodurans and its mutant exhibited full susceptibility to all antibiotics tested (mitomycin C, actinomycin D, chloramphenicol, dihydrostreptomycin, erythromycin, neomycin, kanamycin, benzylpenicillin, bacitracin, and vancomycin), the degree of susceptibility being of the same order as that of a standard strain of Staphylococcus aureus 209 P, with the exception of dihydrostreptomycin.

Anti-Bacterial Agents↗
PubMed1966

The resistance to antibiotics of strains of Staphylococcus aureus isolated in Poland.

The increasing number of antibiotic-resistant strains of micro-organisms is posing serious problems. A nation-wide survey has therefore been carried out in Poland to determine the resistance of strains of Staphylococcus aureus from different sources to eight antibiotics; in all, some 31 000 strains were examined.In general, the most resistant strains from humans were derived from faeces, urine and blood, and the least resistant from bile and pus. Food yielded strains of even lower resistance. Strains from hospital material were, in general, considerably more resistant than those from non-hospital material. The only exception was in resistance to neomycin; the strains most resistant to this antibiotic were obtained from bile and throat, and the least resistant from urine and cerebrospinal fluid; moreover, non-hospital strains were more resistant than hospital ones.ON THE AVERAGE, THE PROPORTIONS OF STRAINS RESISTANT TO THE EIGHT ANTIBIOTICS WERE: penicillin, 84.0%; streptomycin, 69.5%; tetracycline, 60.1%; chlortetracycline, 56.9%; oxytetracycline, 56.7%; neomycin, 56.2%; chloramphenicol, 48.6%; erythromycin, 47.4%.

Anti-Bacterial Agents↗
PubMed1966

The resistance to antibiotics of strains of Streptococcus viridans, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Proteus and Klebsiella isolated in Poland.

A nation-wide survey has been carried out in Poland into the susceptibility of six genera of bacteria to eight antibiotics. The antibiotic-resistance of streptococci differed from that of the Gram-negative rods studied.Escherichia coli, Klebsiella and Pseudomonas aeruginosa are known to be completely resistant to penicillin. Streptococcus faecalis was much more resistant to antibiotics than Streptococcus viridans (highest resistance to streptomycin - 90.3% and 74.9%, respectively; least resistance to chloramphenicol - 47.3% and 9.1%). More than 90% of all Pseudomonas aeruginosa strains isolated were resistant to all the antibiotics; high resistance was also exhibited by E. coli (94.5% resistant to erythromycin and 59.5% to chloramphenicol), Proteus (92.3% to penicillin and 63.0% to chloramphenicol) and Klebsiella (84.0% to erythromycin and 62.8% to oxytetracycline).

Anti-Bacterial Agents↗