PubMed Health⌕ Search

Biomedical subjects

J Hawthorn

Publications and source records attributed to J Hawthorn.

28 records · Page 2Linked to original sources
PubMed1982

Extrahypothalamic vasopressin is unchanged in Parkinson's disease and Huntington's disease.

Vasopressin immunoreactivity was measured post-mortem in the locus coeruleus and substantia nigra of 16 cases of Parkinson's disease and multisystem atrophy, 10 cases of Huntington's chorea and 28 normal controls. Amounts of vasopressin did not differ significantly (P greater than 0.05) between the 3 groups. Immunohistochemistry demonstrated vasopressin within nerve terminals. These data are consistent with an extrinsic vasopressin system in the human locus coeruleus and substantia nigra.

Adult↗
PubMed1981

Extrahypothalamic vasopressin in human brain.

The distribution of arginine vasopressin immunoreactivity in post-mortem human brain was examined using a radioimmunoassay. The highest concentration was found in the hypothalamus but substantial amounts of vasopressin-like immunoreactivity were also found in the locus coeruleus, periaqueductal grey, substantia nigra compacta and reticulata and in lower concentrations in the globus pallidus. The extrahypothalamic vasopressin was immunologically and chromatographically similar to hypothalamic vasopressin. The possibility arises that the high levels of vasopressin in the locus coeruleus may relate to an effect on noradrenergic transmission.

Aged↗
PubMed1980

Localization of vasopressin in the rat brain.

The distribution of arginine vasopressin (AVP) in the rat brain was studied using a sensitive radioimmunoassay. The highest concentration of AVP was found in the hypothalamus. Individually, the supraoptic, paraventricular and suprachiasmatic nuclei contained in the order of 10% of the total hypothalamic content. Vasopressin was also found in the thalamus, medulla, cerebellum, amygdala, substantia nigra and hippocampus. Much lower levels were detected in the pons, spinal cord, frontal and occipital lobes and caudate putamen. No AVP could be detected in any other regions of the cortex or corpus callosum. Chromatographically the vasopressin found outside the hypothalamus is of a similar nature to that of hypothalamo-hypophysial origin. This study supports previous reports of extrahypothalamic localization of vasopressin by immuno-histochemical methods. It is clear that AVP is not confined to the hypothalamo-hypophysial axis, and the possibilities that this may reflect an involvement in brain function are discussed.

Animals↗
PubMed1975

Influence of the pituitary gland on insulin secretion in the genetically obese (ob/ob) mouse.

The influence of the pituitary gland of lean and genetically obese (ob/ob) mice on insulin secretion from microdissected pancreatic islets of lean and ob/ob mice has been studied by perifusing the pituitaries of these animals in series with the isolated islets and measuring insulin secretion at 5-min intervals over a period of 60 min. It has been shown that the pituitary perifusate of both lean and obese mice stimulate insulin secretion from lean mouse islets but not from obese mouse islets. The maximum stimulation occurs in the first 10 min and with the lean mouse pituitaries returns to the basal level in about 20 min, whereas with the obese mouse pituitaries insulin secretion is about double that from the control islets even after 40 min. A concentration of pure porcine ACTH equivalent to about three times the amount released from the pituitary gland under the experimental conditions used, caused only a small stimulation of insulin release. Possible interpretations of these findings and further lines of investigation are discussed.

Adrenocorticotropic Hormone↗