Injectable bromocriptine to treat acute, oestrogen-induced swelling of invasive prolactinoma.
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Adenoma↗
Biomedical subjects
J Hayek
Publications and source records attributed to J Hayek.
CT of meningiomas on the Posterior surface of the petrous bone.
A detailed analysis of the CT findings in 16 surgically verified cases of meningioma of the posterior surface of the petrous bone is presented. The results indicate that a correct preoperative diagnosis is possible in almost every case. Frequently occurring specific CT criteria for meningioma of the posterior surface of the petrous bone include: hyperdense, homogeneously enhancing, extra-axial, CPA mass; inverse relationship between precontrast attenuation value and degree of contrast enhancement of the tumor; oval shape; obtuse angle between lateral tumor border and posterior surface of petrous bone, and evidence of transcisternal supratentorial tumor extension. Infrequently occurring specific CT criteria include: tumor calcification; hyperostosis or exostosis of the posterior surface of the petrous bone; a comma-shaped tumor configuration in cases with transcisternal tumor extension and evidence of transtentorial tumor extension. Oxygen CT cisternography is the most sensitive and reliable technique for detecting small tumors. The CT differential diagnosis of meningioma of the posterior surface of the petrous bone is discussed.
Bone Neoplasms↗
Computed tomography in neuronal ceroid lipofuscinosis.
The computed tomography (CT) findings in a verified case of neuronal ceroid lipofuscinosis (NCL) are presented. CT revealed diffuse and severe cerebral atrophy, reflected by generalized subarachnoid space enlargement and symmetric ventricular dilatation. There was no evidence of abnormalities of the white matter. The CT features in our case of NCL correspond perfectly with the neuropathologic changes of the disease mentioned in the literature. Furthermore, CT is of considerable help in differentiating between those inherited metabolic brain diseases characterized primarily by white matter involvement and those presenting predominantly with changes of grey matter.
Ceroid↗
Computed tomography in cerebral aneurysms with special emphasis on giant intracranial aneurysms.
The computed tomography (CT) findings of 105 patients with a total of 139 intracranial aneurysms are analyzed. The rate of detection of subarachnoid and intracerebral hemorrhage in relation to time since bleeding episode agreed well with previously reported results. Direct visualization of small intracranial aneurysms using 5 mm sections in the postcontrast scan was possible in 58% of the cases. Ten cases of giant intracranial aneurysms (GIA) more than 25 mm in diameter are analyzed in depth. Diagnostic criteria for differentiation of GIA from tumors are discussed. Ring shaped postcontrast enhancement of the outer margin of the aneurysm or curvilinear interrupted calcifications were found in totally or partially thrombosed GIA; central or peripheral homogeneous enhancement of the aneurysm's lumen (target sign) was typical of partially thrombosed GIA; and nonthrombosed GIA usually presented as homogeneously enhancing lesions. Differential diagnostic criteria are discussed.
Adolescent↗
Neuroma of the cavernous sinus.
A case of a surgically verified parasellar neuroma is presented. Despite clinical and radiological evidence for the origin of the tumor to be the trochlear or oculomotor nerves, an operation revealed a neuroma originating from the cavernous sinus, but exact identification of the origin of the tumor was not possible. The radiologic findings including polytomography, angiography and computed tomography are presented. The clinical and radiological differentiation between this case and typical neuromas of the gasserian ganglion are discussed.
Adult↗
Cerebral granulomatous angiitis simulating brain tumor.
A case of surgically verified cerebral granulomatous angiitis, which was mistaken for a brain tumor on computed tomography, is reported. The focal, enhancing lesion was due to multiple confluent infarction caused by the angiitic process.
Adult↗
[Treatment of Parkinson's disease with the combination drug L-carbidopa/L-dopa. Report on a 2 years study].
Forty patients have been treated with Sinemet (L-carbidopa/L-dopa) for a period of up to two years. The results are in agreement with those in the literature. In two-thirds of cases a good to very good improvement was obtained. The principal side effects were dyskinesia, hypotonia, and gastrointestinal and psychotic symptoms, though they seldom necessitated treatment interruption. L-carbidopa/L-dopa affords a real alternative therapy in the modern treatment of Parkinson's disease with L-dopa and a decarboxylase inhibitor. Generally the dosage range was up to a maximum of one tablet three times daily. Sinemet tablets are simple and convenient to handle for both doctor and patient. Dosage titration to therapeutic efficacy can be achieved in one week to ten days without complications, though we recommended a slower titration based on individual patient reaction and requirements.
Carbidopa↗
Kuru-plaques in creutzfeldt-jakob disease.
A case of Creutzfeldt-Jakob disease of cerebellar type is reported. In this case the cerebellar cortex exhibited classical Kuru-plaques. From a comparison of this finding with 50 cerebella from senile patients and patients with cerebellar atrophies it is concluded that the Kuru-plaque is specific for Creutzfeldt-Jakob disease, possible even for its cerebellar variant.
Aged↗
Computed tomography in nonketotic hyperglycinemia.
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Amino Acid Metabolism, Inborn Errors↗
Computed tomography of gliomatosis cerebri.
Two cases of gliomatosis cerebri which underwent serial CT-examination with contrast enhancement and histological examination of autopsy material are presented. No one single CT showed all the lesions discovered on neuropathological examination, the lesions in the brainstem, basal ganglia and cerebellum being isodense. The presentation of the lesions on CT was in both cases different. In one case there were several hypodense areas predominantly scattered throughout the white matter of both hemispheres, in the other the main lesion was a "tumor' of the corpus callosum, which lead to the decision for operation. Both cases showed periventricular enhancement expressing the histologically verified periventricular spread of tumor cells. Contrast enhancement appeared in the late stages of the diseases. In the different diagnosis, pseudotumor cerebri, multiple sclerosis, encephalitis and multiple brain metastases are considered. Bearing the possibility of gliomatosis cerebri in mind, CT would help limit the differential diagnosis, especially on the basis of serial CT examinations and in combination with the clinical course.
Adult↗
Immunocytochemical staining of Kupffer and endothelial cells in fine needle aspiration cytology of hepatocellular carcinoma.
OBJECTIVE: To evaluate the significance of the presence of Kupffer and endothelial cells in distinguishing hepatocellular carcinoma (HCC) and adenocarcinoma (AC) on cytologic smears. STUDY DESIGN: Fine needle aspiration biopsies (FNABs) from 43 cases, 21 HCC and 22 AC (8 primary and 14 metastatic), were immunostained for Factor VIII and vimentin as markers for endothelial cells and Kupffer cells, respectively. Cytologic diagnosis was verified by histologic and/or clinical follow-up. RESULTS: Eighteen of the 21 cases (86%) of HCC and 11 (5 primary and 6 metastatic) of 22 cases (50%) of AC showed positive immunostaining for Factor VIII (P = .02). Vimentin immunostaining was positive in 55% of HCCs and 41% of ACs (P = .74). Forty-five percent of cases of HCC showed immunostaining for both Factor VIII and vimentin, while 22% of cases of AC showed immunostaining for both Factor VIII and vimentin (P = .18). CONCLUSION: Immunocytochemical identification of endothelial cells using Factor VIII may have important diagnostic value in separating HCC from adenocarcinomas in liver FNABs. The presence of Kupffer cells labeled with vimentin has no diagnostic significance in FNAB of these tumors.
Adenocarcinoma↗