Possible association of erythema multiforme with acamprosate.
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Biomedical subjects
Publications and source records attributed to J Hemet.
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The authors report a case of pyeloureteric adenocarcinoma in a urinary diversion inserted for bladder exstrophy and in a context of chronic pyelonephritis secondary to renal stones. The various aetiopathogenic hypotheses are discussed. Renal stones and chronic inflammation very probably played an important role in the development of this type of adenocarcinoma in the urothelium.
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A case of metastasizing pleomorphic adenoma is reported with a review of the literature. It's a enigmatic lesion of the parotid gland in with both the primary tumor and metastasis were composed of benign pleomorphic structures. We think that some intra or extra cellular factors mut be discovered to recognize the malignant potential of this tumors and further to understand all cancerous pathology.
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The authors report two new cases of segmental dilatation of the small bowel at birth. In the pathological intestinal areas, they describe inflammatory alterations similar to neonatal necrotizing enteritis, and some particular lesions of the myenteric plexus with a deterioration of the ganglionic cells. It is suggested that such lesions might have a certain responsibility in the etiology of chronic idiopathic pseudo-obstruction syndrome.
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Although the macroscopic aspects of chondrocalcinosis easily permit diagnosis, the morphological analysis of the basic lesion--the crystalline microgeode--raises the problem of the relationship between chondrocalcinosis and the chondrocyte lodge and arthrotic lesions. According to studies with the optical and electron microscope, the crystalline precipitate of calcium pyrophosphate in the basic cartilaginous substance always appears distinct from the chondrocytes, but in its vicinity the chondrocytes are often altered by degenerative lesions. There appears to be no relationship between arthrosis and chondrocalcinosis of frequency alone is considered.
A respiratory functional test was done systematically on 24 patients with chronic hepatitis and was found normal in only 2 cases. It showed an alteration of the transfer in 14 patients and a syndrom of hyperinflation in 8 others. Despite the histopathological proof it seems that the transfer alteration could be attributed to diffuse interstitial pulmonary lesions. They have already been noted in chronic hepatitis by several authors. The pathogeny of this interstitial involvement probably implied immunity phenomenons including the participation of the antigen Australia or others. As for the hyperinflation syndrome observed in 4 patients in the absence of any bronchopulmonary history, it could reveal an emphysema, which, so far, had not been seen associated to chronic hepatitis.
Women 63-between 1949 and 1970 has shown 11 K. A., 1 Bowen's diseas of the vulva, a carcinoma of the rectum (together with a carcinoma of the anus). This last association allows to integrate this observation to Torre's syndrome. No return of the K. A. since the removal of the carcinomas (1970) which have not actually come out again.
Eleven patients with primary hyperparathyroidism confirmed by histologic examination were subjected to a comparative study of the results of quantitative determination of parathormone and of quantitative bone biopsy. Quantitative radioimmunologic determination of parathormone was carried out with the aid of an N-terminal specific anti serum, while the histologic features studied were the periosteocytic and osteoclastic absorption surfaces. On the basis of a combination of the results of these two techniques, the diagnosis could be made in all the cases studied. A statistically significant correlation was observed between the results of quantitative determination of parathormone and those of histologic examination of the surfaces of periosteocytic lacunae (r = 0.63; p = 0.05).
The authors report 7 new cases of colitis above a carcinoma. The study of these cases and of those reported in the literature shows the main pathological characteristics of the lesions and permits discussion of the pathogenesis. Chronic ischemia caused by an increase in intraluminal pressure above the neoplastic stenosis seems to be the main etiological factor.
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The authors report here a case of antral hemorrhagic gastritis without ulceration nor erosion, but with intravascular coagulation within the chorionic layer, which had a prolonged course in a patient with non-alcoholic cirrhosis, and which continued in spite of surgical cure of portal hypertension. The authors discuss various theories which might explain this hemorrhage and the development of localised intravascular coagulation, together with its relationship with the cirrhosis.
Coxopathies with rapid chondrolysis: Comparison of clinical and anatomical findings. Clinical, radiological, laboratory, and antomical data concerning 14 coxopathies with rapid chodrolysis are presented with reference to 12 patients aged from 37 to 77 years. Three criteria define this affection: reduction of the joint space by at least 50 per cent, in one year or less; chondrolysis completed in 1 to 3 years; complete narrowing in the superior part of the joint; isolated narrowing, exceptionally with a discrete osteophytosis. The pain rapidly becomes very severe. Such symptoms are, at first, indicative of coxitis, but the establishment of a radio-clinical picture of coxopathy rapid chrondrolysis is more indicative of an arthrosic origin. This could represent a particular evolutive stage of coxarthrosis related to the initial chondrolytic phase of rapid destructive coxarthrosis. From an early stage, the anatomical facts indicate an association between the degenerative lesions and the non-specific inflammatory lesions of the synovial membrane. These facts are interpreted, on the basis of data in the literature, as an indication of synovial lesions caused by the liberation of osteocartilaginous fragments. The problem of the pathogenesis of this rapid chondrolysis is then discussed.