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Biomedical subjects

J Hendl

Publications and source records attributed to J Hendl.

At least 19 recordsLinked to original sources
PubMed2002

[Meta-analysis in medicine].

Systematic reviews are widely used in medicine as a method of decision making based on evidences. The systematic review is a method of locating and evaluation of a synthesising evidence. Meta-analysis refers to quantitative synthesis of the results of clinical trials or other primary studies. Simple introductory account about meta-analysis is given. We describe two examples of meta-analysis application and strengths and weaknesses of this research method.

Evidence-Based Medicine↗
PubMed1992

[Energy expenditures in patients with acute and chronic catabolic conditions].

The authors investigated the energy expenditure and utilization of different nutrients by indirect calorimetry. They examined three groups of subjects: patients with acute febrile diarrhoeal diseases (n = 36), patients with subacute to chronic severe febrile diseases (n = 10) and healthy subjects (n = 21). The measurements were made three times a day. In all groups the energy requirements of the organism were met in the morning above all by fats, in the course of the day the ration of utilized carbohydrates increased markedly. The authors discuss the problem of optimal nutrition of patients in a critical condition from the quantitative and qualitative aspect.

Acute Disease↗
PubMed1991

[Reliability of the SRK formula].

The authors investigate the postoperative dioptric deviation from the calculated dioptric power of emetropic intraocular lenses by means of the SRK formula. The deviation varied in 82% of the operated eyes within the range of +/- 1.5 D. More accurate calculations were achieved in a group of eyes with a normal axial length of the eyeball (22.0 to 24.5 mm). The authors discuss also circumstances which influence the accuracy of calculation according to formula SRK (assessment, calculation) and factors participating in the final postoperative refraction (different surgical techniques).

Aged↗
PubMed1990

[Suitable variables for the evaluation of combined acid-base disorders: residual anions, buffer base sera, proteins and delta bases].

In 254 findings of the acid-base balance ions and proteins, the authors evaluated mutual relations between the acid-base balance and calculation from the anion column. Contrary to the commonly used anion gap value, the authors used concurrently for evaluation buffer base sera, serum protein values and residual anions. The logical result of summarization of these three parameters is the creation of a new term, delta bases, which correlates closely with the resulting metabolic acid-base situation. The optimal relationship of the mentioned parameters to the value of base excess is described by the following equation: BE = 0.805*BBS--0.852*RA--0.204*SProt--15.8 which is consistent with the theoretical value of delta bases.

Acid-Base Equilibrium↗
PubMed1989

[Prognosis in patients in intensive care from the aspect of renal function].

The authors evaluated in 82 patients 228 findings of renal functions. Twenty-nine patients with a total number of 113 findings died. In those who died frequently the values of renal functional parameters were beyond the reference limits, indicating various failures (high serum creatinine, high serum urea, elevated fractional osmolal and water excretion, reduced creatinine clearance). In those who died tubular osmotic diuresis was more frequent, while overflow osmotic diuresis was found mostly in the surviving patients. By means of linear discrimination analysis vectors of parameters were assessed suitable for evaluation of the relationship of renal functions and the prognosis and functional shapes of so-called renal prognostic indicators. In the calculation of renal prognostic parameters the following ones prove useful: serum creatinine (SKrea), creatinine clearance (CKrea), serum osmolality (SOsm), osmolality of urine (UOsm), sodium cation in serum (SNa), fractional excretion of water (FeH2o), of potassium (FeK), osmolal (FeOsm), urinary excretion per 24 hours of creatinine (DuKrea), sodium (DuNa) and potassium (DuK). The best prognostic effectiveness was obtained from the calculation of the renal prognostic indicator (RPU) according to the following equation: RPU = SOsm.0.0178--CKrea.0.944 + FeK.0.854 + + DuKrea.0.0665--DuNa.0.0022 + DuK.0.0047--4.931. The RPU value rises with the deteriorating prognosis of the patients; in those who died it reaches more frequently positive values, in surviving patients the values are negative. By reclassification, using this prognostic index, 82% of the patients with a favourable prognosis and 68% with a poor prognosis (those who died) were correctly classified, i. e. a total of 74% patients.

Critical Care↗
PubMed1985

Incidence of colorectal cancer in proctocolitis: a retrospective study of 959 cases over 40 years.

The incidence of colorectal cancer was studied by the actuarial method in 959 patients with idiopathic proctocolitis seen from 1942 to 1981. Forty five per cent had rectal, 23% left-sided, and 32% total involvement of the colon. Six cancers were found: one in the rectal, one in the left-sided, and four in the total form of the disease. The risk of cancer per patient year in total colitis was zero per 2151 patient years in the first decade, 1/462 in the second decade, 1/315 in the third decade, and 1/75 in the fourth decade. The cumulative risk of developing cancer was zero at 10 years of duration of the disease, approximately 5% at 20 years, 15% at 30 years, and 20% at 35 years. This increase in risk of cancer is less than reported in some other series. Geographical differences in the incidence of cancer in proctocolitis could influence the risk and therefore also the long-term management of patients with proctocolitis in different geographical areas.

Age Factors↗