Biomedical subjects
Publications and source records attributed to J Henkes.
A case of excess granulation tissues in a patient treated with isotretinoin by a severe cystic acne is reported. Other cases described in the literature are reviewed.
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Three cases of multiple granular cell myoblastoma are reported. In the discussion the authors emphasize the frequency, pathogeny, evolution and new classification of this type of proliferative disorders.
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Six patients are described who experienced a prodromal period suggesting an infective process, followed by a distinctive polymorphous cutaneous eruption. The most striking lesion, present in all of them and giving the eruption a distinctive herpetiform appearance, included closely grouped vesicles resting on an erythematous base. Histopathological examination of these lesions showed features of dermal and epidermal types of erythema multiforme but with prominent leukocytoclasis. We suggest that the clinico-pathological picture of our patients may be considered a distinctive clinico-pathological variety of erythema multiforme.
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An acute zinc deficiency state developed in 6 patients on total parenteral alimentation, which allegedly included zinc 37 mumol/l. The actual concentration of this trace element when measured by us, was 3 mumol/l. The clinical picture consisted of an acrodermatitis enteropathica-like syndrome, with subsequent development of distinctive nail lesions, which consisted of white transverse bands in all finger- and toenails. Histopathological examination of several of these cutaneous lesions revealed distinctive changes, which we consider rather specific of zinc deficiency states. They consisted in parakeratosis, cleavage and detachment of the superficial layers of the epidermis, mainly intracellular and also extracellular edema of the epidermal cells, development of microvesicles at different epidermal levels, and severe vacuolar alteration of the dermoepidermal junction. These changes also affected the outer root sheath of the hair follicles.
An 8-year old boy with generalized morphea involving all levels of the skin and soft tissues with disabling course, policlonal elevation of gammaglobulins and peripheral eosinophilia is examined. Neither Raynaud's disease nor sings of systemic scleroderma were present. The biopsy specimen showed thickening and hyalinization of collagenous tissue with moderate lymphocytic and plasma cell infiltration, mainly in the subcutaneous region and fascia. A diagnosis of Disabling Panscleroti morphea of children (Díaz-Pérez et al., 1980) was done. With this case and others reported in the literature, the authors compare this peculiar picture with the usual type of morphea, systemic scleroderma and eosinophilic fasciitis.
The clinico-pathological and therapeutics features of two cases of nodular hidradenoma are reported. The polymorphic microscopic picture that characterizes this peculiar tumor can be seen in one of our observations. The other case belongs to the variety called "clear cell hidradenoma". The latter of big size and with local adenopathies showed a prompt regression to treatment with bleomycin.
A case of acute pityriasis lichenoides associated with a distal ischemia and a similar evolution is reported. The vasculitic cause is demonstrated by angyologic exploration. The gross vascular afectation other than dermal vessels is suggested.
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