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Biomedical subjects

J Henne

Publications and source records attributed to J Henne.

10 recordsLinked to original sources
PubMed2001

The continuing HIV epidemic among men who have sex with men.

OBJECTIVES: This study characterized the AIDS epidemic among urban men who have sex with men (MSM). METHODS: A probability sample of MSM was obtained in 1997 (n = 2881; 18 years and older) from New York, Los Angeles, Chicago, and San Francisco, and HIV status was determined through self-report and biological measures. RESULTS: HIV prevalence was 17% (95% confidence interval = 15%, 19%) overall, with extremely high levels in African Americans (29%), MSM who used injection drugs (40%), "ultraheavy" noninjection drug users (32%), and less educated men (< high school, 37%). City-level HIV differences were non-significant once these other factors were controlled for. In comparing the present findings with historical data based on public records and modeling, HIV prevalence appears to have declined as a result of high mortality (69%) and stable, but high, incidence rates (1%-2%). CONCLUSIONS: Although the findings suggest that HIV prevalence has declined significantly from the mid-1980s, current levels among urban MSM in the United States approximate those of sub-Saharan countries (e.g., 14%-25%) and are extremely high in many population subsegments. Despite years of progress, the AIDS epidemic continues unabated among subsegments of the MSM community.

Adolescent↗
PubMed2001

The impact of homophobia, poverty, and racism on the mental health of gay and bisexual Latino men: findings from 3 US cities.

OBJECTIVES: This study assessed the relation between experiences of social discrimination (homophobia, racism, and financial hardship) and symptoms of psychologic distress (anxiety, depression, and suicidal ideation) among self-identified gay and bisexual Latino men in the United States. METHODS: Data were collected from a probability sample of 912 men (self-identified as both Latino and nonheterosexual) recruited from the venues and public social spaces identified as both Latino and gay in the cities of Miami, Los Angeles, and New York. RESULTS: The study showed high prevalence rates of psychologic symptoms of distress in the population of gay Latino men during the 6 months before the interview, including suicidal ideation (17% prevalence), anxiety (44%), and depressed mood (80%). In both univariate and multivariate analyses, experiences of social discrimination were strong predictors of psychologic symptoms. CONCLUSIONS: The mental health difficulties experienced by many gay and bisexual Latino men in the United States are directly related to a social context of oppression that leads to social alienation, low self-esteem, and symptoms of psychologic distress.

Adult↗
PubMed2000

Voltage-gated potassium channels in retinal ganglion cells of trout: a combined biophysical, pharmacological, and single-cell RT-PCR approach.

Retinal ganglion cells of young mature trout were acutely isolated by tissue printing and analyzed with the whole-cell mode of the patch-clamp technique in combination with single-cell RT-PCR. All cells either exhibited spontaneous spiking activity or could be induced to fire trains of action potentials by current injection. Depolarizing voltage steps elicited a TTX-sensitive sodium inward current and a complex outward current that could be subdivided into a calcium-dependent component that was sensitive to 100 nM iberiotoxin as well as three major types of voltage-sensitive currents: 1) a high-threshold (-20 mV) noninactivating current that was highly sensitive to submicromolar TEA and quinine, resembling recombinant mammalian Kv3.1 channels; 2) a low-threshold DTX-sensitive current, matching mammalian Kv1; and 3) a fast-inactivating transient current that was highly sensitive to TEA (3 mM) but resistant to alpha-DTX (1 microM) and quinine (0.1 mM). By multiplex single-cell RT-PCR, coexpression of multiple transcripts encoding Shaker-related channel genes of trout (termed Tsha1-Tsha4) as well as two Shaw-related channels (termed Traw1 and Traw2) could be demonstrated in individual cells.

Action Potentials↗
PubMed2000

Molecular cloning and functional characterization of Shaw-related potassium channels of trout CNS.

Two Shaw-related potassium channels expressed in the CNS of trout were PCR cloned and sequenced: Traw1 was identified as a fish homologue to mammalian K(v)3.1, while Traw2 could not be exactly classified. Upon heterologous expression Traw1 exhibited a high threshold (-20 mV) non-inactivating delayed rectifier current that was efficiently blocked by submicromolar concentrations of TEA, 4-AP and quinine but not by alpha-DTX or apamin. The amplitude of the Traw1 induced current was reduced by the phorbol ester TPA, the effect being prevented by the proteinkinase inhibitor H7. Transcripts of both Shaw- related channels possess a widespread distribution in the mature brain tissue and outside the nervous system are detectable in muscle but not in liver. During brain development Traw1 mRNA was initially identified at stage 31 (shortly after hatching) while transcripts encoding Traw2 were detectable already at stage 28 (1 week before hatching).

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine↗
PubMed1992

A comparison of younger and older gay men's HIV risk-taking behaviors: the Communication Technologies 1989 Cross-Sectional Survey.

Data from the 1989 Communication Technologies cross-sectional survey of gay men in San Francisco indicate that both levels and correlates of sexual risk are different between younger and older gay men. Gay men under the age of 30 report higher risk behavior for human immunodeficiency virus (HIV) infection than do gay men who are 30 years of age or older. Further, the set of correlates of unprotected anal intercourse are different between younger and older gay men. Both young and old gay men report that having a primary partner and a lower perceived impact of the AIDS epidemic on their sexual behavior are associated with risk. However, among young gay men, reporting a lower attributed risk for HIV infection to unprotected anal intercourse, higher concern about AIDS risks, and shorter length of residence in San Francisco are positively correlated with risk-taking behavior. These associations were not statistically significant among gay men 30 years of age or older. It appears that the circumstances and/or reasons for taking sexual risk are different between older and younger gay men. Prevention programs must be designed so that they are sensitive to the needs of each generation of gay men.

Adolescent↗
PubMed1991

Changes in condom use among homosexual men in San Francisco.

Employed data from two longitudinal surveys of gay men in San Francisco (a) to examine for cohort (Study 1) and attrition (Studies 1 and 2) bias effects on reported changes in condom use by gay men and (b) to investigate predictors of condom use (Study 2). Substantial increases in condom use were observed, and these changes were unrelated to attrition and cohort bias. In terms of predictors of condom use, men who always used condoms had higher levels of social support from informal sources of help, had more positive expectations that condoms would have positive interpersonal and personal consequences, and were more likely to be HIV positive than men who used condoms occasionally or never. The results are discussed in terms of their implications for HIV-prevention research.

Adult↗
PubMed1991

[Experimental studies on the effectiveness of intraligamental anesthesia].

In this study the effectiveness of the periodontal ligament injection was tested in rats. Anesthetic solutions with carbon dye were injected into the crestal periodontal ligament space under back-pressure. Vital microscopic observations showed that the solution spreads via an intraosseous path into the vessels of the pulp. These results support the contention that the periodontal ligament injection is intravascular in nature. Therefore, possible cardiovascular responses to periodontal ligament injections containing catecholamines must be considered.

Anesthesia, Dental↗
PubMed1988

Attitudes about AIDS.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗
PubMed1988

Attitudes about AIDS.

Explore the source record for details and available documents.

Acquired Immunodeficiency Syndrome↗