New myocardial perfusion imaging agents: description and applications.
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Fatty Acids↗
Biomedical subjects
J Heo
Publications and source records attributed to J Heo.
Dipyridamole cardiac imaging.
Dipyridamole cardiac imaging is a useful alternative technique to exercise stress testing in the evaluation of patients with ischemic heart disease. Intravenous dipyridamole is still in the investigational phase, while oral dipyridamole is widely available. The hemodynamic effects of dipyridamole include an increase in coronary blood flow (due to coronary vasodilation) which is in excess of the increase in myocardial oxygen consumption and cardiac output. The disparity in the increase in coronary blood flow relative to the cardiac output results in an increase in myocardial thallium activity and an increase in the myocardial/background activity ratio. The quality of the thallium images is better or similar to that of exercise thallium images. The optimal dose of intravenous dipyridamole is 0.56 mg/kg, and of the oral dose it is 300 to 400 mg, although higher doses may be necessary in some patients. Analysis of the thallium images has been to a large extent based on visual inspection of the planar images. Delayed images are helpful to establish the nature of the perfusion abnormalities (transient or fixed). The process of redistribution is based on disparate rates of washout from the normal and abnormal zones. The sensitivity and specificity of dipyridamole thallium imaging, whether intravenous or oral, have been shown in a number of studies to be quite adequate and comparable to that achieved during exercise thallium imaging. Dipyridamole two-dimensional echocardiography has also been used in the detection of coronary artery disease; transient (new or worsening of preexisting) wall motion abnormalities have been found to be a specific marker of coronary artery disease. Transmural as well as regional coronary steal phenomena have been postulated as the mechanism for dipyridamole-induced regional wall motion abnormalities. Compared to exercise two-dimensional echocardiography, dipyridamole echocardiography provides high-quality studies and in higher proportions of patients. The results of dipyridamole thallium imaging have also been extremely important in identifying high-risk patients after acute myocardial infarction or patients with peripheral vascular disease undergoing elective vascular surgery; the presence of a dipyridamole-induced perfusion abnormality identifies patients at high risk for future cardiac events. Thus, dipyridamole cardiac imaging is helpful in the diagnosis of coronary artery disease and in risk stratification.
Animals↗
Left ventricular diastolic function: evaluation by radionuclide angiography.
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Angiography↗
Exaggerated systolic blood pressure response to exercise: a normal variant or a hyperdynamic phase of essential hypertension?
This study examines the left ventricular function (by first-pass radionuclide angiography with a multicrystal gamma camera) at rest and during symptom-limited upright exercise in 27 normal subjects (group 1), 25 normotensive subjects with exaggerated systolic blood pressure response to exercise (greater than 200 mm Hg) (group 2) and 25 patients with essential hypertension and no associated coronary artery disease (group 3). There were no significant differences between groups 1 and 2 in exercise tolerance, heart rate, total vascular resistance, left ventricular ejection fraction and end-systolic volume. However, the exercise cardiac index and systolic blood pressure were significantly higher in group 2 (P less than 0.02). Compared to group 3, the subjects in group 2 had higher exercise heart rate (P less than 0.0001), cardiac index (P less than 0.0001), systolic blood pressure (P less than 0.0001) and left ventricular ejection fraction (P less than 0.0001) and lower exercise total vascular resistance (P less than 0.0002) and end-systolic volume (P less than 0.01). Thus, the hemodynamic profile in subjects with exaggerated systolic blood pressure response to exercise differs from that of essential hypertension; it may represent a supernormal response.
Adult↗
Massive extracardiac thallium accumulation in pulmonary carcinoma.
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Aged↗
Factors affecting exercise left ventricular performance in patients free of obstructive coronary artery disease.
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Coronary Disease↗
The role of radionuclide cardiac imaging in coronary artery bypass surgery.
The main applications of cardiac nuclear imaging in coronary artery bypass surgery include: patient selection, prediction of improvement in resting LV function after revascularization, diagnosis of perioperative myocardial infarction, assessment of the results of revascularization, evaluation of new or recurrent symptoms, and in risk stratification. Proper understanding of which test to be used, when, and why may be important to optimize patient management.
Coronary Artery Bypass↗
Effects of beta blockade on systolic and diastolic left ventricular function at rest and during exercise in patients with chronic stable angina pectoris.
This study examined the effects of beta blockade with betaxolol, a cardioselective, lipid-soluble, beta-adrenergic-blocking agent, on rest and exercise systolic and diastolic left ventricular function in 15 patients, aged 40 to 70 years (mean = 52), with chronic stable angina pectoris. Each patient underwent three upright exercise studies at identical workloads; the first was a baseline study, the second was done 3 hours after a single oral dose, and the third was obtained after chronic therapy for 2 weeks. Beta blockade was evident by significant decreases in heart rate, systolic blood pressure, and diastolic blood pressure at rest and during exercise (p less than 0.04). Although there were no significant changes (at rest or during exercise) in mean left ventricular ejection fraction and peak filling rate, individual variations were seen after 3 hours and 2 weeks of therapy. During chronic therapy, the peak filling rate increased in three patients, decreased in five, and remained unchanged in seven. Also, discordant changes in systolic and diastolic functions were seen at rest and during exercise during both acute and chronic therapy. Thus, although acute and chronic beta blockade produces no significant changes in mean measurements of diastolic and systolic left ventricular performance, individual variations and discordant results are seen in many patients. The acute effects are generally consistent with the chronic effects, but exceptions are present.
Adrenergic beta-Antagonists↗
Merits and limitations of quantitative treadmill exercise score.
This study examined the ability of the treadmill exercise score (TES) in determining the presence and extent of coronary artery disease (CAD). The score was derived from the integrated area of ST segment depression and ST slope in two leads (V5 and a VF), corrected for R wave amplitude, exercise time, and percent of maximum predicted heart rate. The ST segment depression was measured at 80 msec after the J point. There were 34 patients with no significant CAD, 38 patients with one-vessel CAD (greater than or equal to 50% diameter stenosis), and 58 patients with multivessel CAD. The TES showed a considerable scatter in patients with and without CAD. A receiver operating characteristic curve showed different levels of sensitivity and specificity, depending on the cut-point. The TES was similar to ST segment depression in detecting CAD (predictive accuracy, 77% vs 78%, p = NS). A markedly abnormal score (less than -1.0) was seen in 41 patients, of whom 32 (78%) had multivessel CAD. On the other hand, a score greater than 0 was seen in 49 patients, of whom 40 (82%) had no or one-vessel CAD. In 40 patients with TES between -1.0 and 0, 17 (43%) had multivessel CAD and 23 (57%) had no or one-vessel CAD. In 51 patients with nondiagnostic ST changes, the TES correctly classified the extent of CAD in 20 patients (40%). Thus, the TES has a similar accuracy to the ST segment depression criteria in detecting CAD. The extent of CAD can, however, be ascertained in 80% of the patients with very high or very low TES.
Adult↗
Thallium imaging with single photon emission computed tomography.
Evaluation of myocardial perfusion with thallium-201 SPECT has advantages over planar images. These advantages are related to better contrast of the images, lack of superimposition of normal and abnormal areas, and a three-dimensional representation of the site and extent of perfusion abnormalities (ischemia, scar, or both). For this reason, rotational tomography is superior to planar imaging in assessing the extent of coronary artery disease, in the detection of small infarcts, and for quantitative measurements. Several techniques have provided accurate quantitative data for infarct sizing both in animals and men. The ability to quantitate infarct size (or ischemia) will be extremely important in studies of myocardial salvage, risk stratification, and longitudinal studies to evaluate the effects of medical and surgical interventions.
Animals↗
Relative prognostic value of rest thallium-201 imaging, radionuclide ventriculography and 24 hour ambulatory electrocardiographic monitoring after acute myocardial infarction.
Rest thallium-201 scintigraphy, radionuclide ventriculography and 24 hour Holter monitoring are acceptable methods to assess myocardial necrosis, performance and electrical instability. This study examined the relative value of the three tests, when obtained a mean of 7 days after acute myocardial infarction, in predicting 1 year mortality in 93 patients. Planar thallium-201 images were obtained in three projections and were scored on a scale of 0 to 4 in 15 segments (normal score = 60). Patients were classified as having high risk test results as follows: thallium score less than or equal to 45 (33 patients), left ventricular ejection fraction less than or equal to 40% (51 patients) and complex ventricular arrhythmias on Holter monitoring (36 patients). During the follow-up of 6.4 +/- 3.4 months (mean +/- SD), 15 patients died of cardiac causes. All three tests were important predictors of survival by univariate Cox survival analysis; the thallium score, however, was the only important predictor by multivariate analysis. The predictive power of the thallium score was comparable with that of combined ejection fraction and Holter monitoring (chi-square = 21 versus chi-square = 22). Thus, rest thallium-201 imaging performed before hospital discharge provides important prognostic information in survivors of acute myocardial infarction which is comparable with that provided by left ventricular ejection fraction and Holter monitoring. Patients with a lower thallium score (large perfusion defects) are at high risk of cardiac death during the first year after infarction.
Adult↗
Chronic myocardial ischemia and left ventricular function.
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Chronic Disease↗
Exercise thallium imaging in patients with diabetes mellitus. Prognostic implications.
We used exercise thallium 201 imaging in 123 patients with diabetes mellitus (77 men and 46 women, aged 56 +/- 8 years), 75% of whom had angina pectoris (typical or atypical). During exercise testing, 18 patients (15%) had angina pectoris, 28 (23%) had ischemic ST changes, and 69 (56%) had abnormal thallium images. During follow-up (up to 36 months), there were 12 cardiac events; four patients died of cardiac causes and eight had nonfatal acute myocardial infarction. Univariate and multivariate survival analysis identified two independent predictors of cardiac events: the event rate was significantly less in patients with normal images and exercise heart rate over 120 beats per minute than in patients with abnormal images and exercise heart rate of 120 beats per minute or less (0% vs 22%). The patients with abnormal images or exercise heart rate of 120 beats per minute or less had an intermediate event rate (11.5%). Furthermore, two of the 54 patients with normal images and ten of 69 patients with abnormal images had subsequent cardiac events. Thus, exercise thallium imaging is useful in risk stratification in patients with diabetes mellitus.
Adult↗
Implications of abnormal right ventricular thallium uptake in acute myocardial infarction.
The correlates of abnormal right ventricular (RV) thallium uptake were examined in 116 patients with documented acute myocardial infarction (AMI) who underwent predischarge thallium-201 scintigraphy at rest, radionuclide angiography and 24-hour ambulatory electrocardiography. The patients were separated into 2 groups: patients group 1 (n = 31) had increased RV thallium uptake and those in group 2 (n = 85) had no such uptake. The 2 groups were comparable in age, type and site of AMI, peak creatine kinase level, systolic blood pressure and heart rate. However, compared with group 2, group 1 had a lower mean left ventricular (LV) ejection fraction (33 +/- 15% vs 39 +/- 14%, p less than 0.05), higher prevalence of increased lung thallium uptake (45% vs 22%, p less than 0.02), more extensive LV perfusion defects (4.4 +/- 2.9 vs 3.0 +/- 3.0 segments, p less than 0.03) and more complex ventricular arrhythmias (55% vs 35%, p less than 0.05). At a mean follow-up of 6 months, 17 patients (8 in group 1 and 9 in group 2) died from cardiac causes. Actuarial life-table analysis showed that the survival rate was better in group 2 than in group 1 (Mantel-Cox statistics = 4.62, p = 0.03). Thus, patients with AMI and abnormal RV thallium uptake have worse LV function, more complex ventricular arrhythmias and worse prognosis.
Adult↗
Age- and gender-related changes in exercise left ventricular function in mitral valve prolapse.
The correlates of exercise left ventricular (LV) performance were examined in 45 patients with isolated mitral valve prolapse (no associated mitral regurgitation or coronary artery disease). There were 18 men and 27 women, aged 16 to 73 years; 20 patients were 40 years or younger and 25 were older than 40. The response of the LV ejection fraction (EF) to symptom-limited upright exercise was normal (at least a 5% increase) in 27 patients (60%) and abnormal in 18 (40%). There were no significant differences between patients with normal and abnormal EF response in clinical presentation, electrocardiographic findings (at rest or during exercise), medications, rest EF, heart rate (at rest or during exercise) and systemic arterial pressure (at rest and during exercise). A normal EF response was observed more frequently in patients 40 years or younger than in those older than 40 (80 vs 44%, p less than 0.01), and more often in men than in women (78 vs 48%, p less than 0.04). The change in EF from rest to exercise was 18 +/- 9% in men and 5 +/- 10% in women 40 years or younger (p less than 0.01), and 9 +/- 8% in men and 2 +/- 8% in women older than 40 (p less than 0.04). Thus, patients (especially women and those older than 40 years) with isolated mitral valve prolapse may have abnormal LV functional reserve. Genetic differences in the expression of the disease in both sexes and age-related irreversible myocardial changes may explain these observations.
Adolescent↗
Relation between left ventricular diastolic function and exercise tolerance in patients with left ventricular dysfunction.
Previous studies show no correlation between resting systolic left ventricular performance assessed as the ejection fraction and exercise tolerance. This study examined the relation between left ventricular diastolic performance and exercise tolerance in 63 patients with left ventricular dysfunction (ejection fraction less than 50%) due to known or suspected coronary artery disease. The 51 men and 12 women, aged 54 +/- 8 years (mean +/- standard deviation), underwent symptom-limited upright exercise testing on a bicycle ergometer. The exercise end-points were angina (n:5), dyspnea (n:16), and fatigue (n:42). The patients were divided into three groups: group 1 (n:28) with normal exercise tolerance (9.5 +/- 2.4 minutes), group 2 (n:18) with mild exercise intolerance (5.8 +/- 0.5 minutes), and group 3 (n:17) had severe exercise intolerance (3.7 +/- 0.9 minutes). The three groups did not differ in age, ejection fraction, end-diastolic volume, exercise end-point, exercise heart rate, and left ventricular peak filling rate at rest. The exercise peak filling rate was, however, significantly higher in group 1 (p = 0.03). Stepwise multivariate discriminant analysis of important variables identified the exercise peak filling rate as the only predictor of exercise tolerance (F = 6.0). Thus, variation in exercise peak filling rate may in part explain the variability of exercise tolerance in patients with left ventricular dysfunction; patients with preserved exercise capacity have higher exercise peak filling rate than those with exercise intolerance.
Adult↗
Radionuclide angiographic evaluation of left ventricular performance at rest and during exercise in patients with aortic regurgitation.
Radionuclide angiographic evaluation of LV performance at rest and during exercise in patients with AR have shown that an abnormal EF response to exercise may be observed in asymptomatic patients with normal resting LV function. The EF response to exercise has been correlated with a number of clinical and exercise measurements; important among these are the slope of the systolic pressure-to-end-systolic volume, end-systolic volume, cardiac index, pulmonary capillary wedge pressure, and wall stress. The changes in the regurgitant fraction, EF, and LV volume have shown considerable individual variability; they have also allowed a better understanding of the circulatory responses during exercise. Radionuclide angiography provides a reliable and reproducible method of measuring the rest LVEF that is important in the timing and the outcome of valve replacement. The value of the EF response to exercise in patient management is not yet clear; it is possible that other radionuclide-derived measurements at rest or during exercise, such as the systolic pressure-to-end-systolic volume relationship, and the end-systolic volume may provide complementary information to that provided by the EF.
Aortic Valve↗
Left ventricular pressure/volume relationship in coronary artery disease.
This study examined the changes during exercise in LV EF and P/V relationship (systolic blood pressure/end-systolic volume index ratio) in 287 patients. Normal range (mean +/- standard deviation) for exercise EF, exercise P/V, and the changes from rest to exercise (delta) in EF and P/V were established in 51 subjects with less than 1% probability of CAD. The results were compared to those obtained in 53 patients with normal coronary angiograms and 183 patients with angiographically proven CAD. Abnormality in either delta EF or percent delta P/V were observed in 76% of the patients with one-vessel disease and in 91% of patients with multivessel disease. Abnormalities in either delta EF or percent delta P/V were more common than delta EF alone in the total CAD group and in subgroups stratified according to the resting EF, extent of CAD, and adequacy of exercise end points. Similar results were obtained when absolute exercise EF or exercise P/V were used. Abnormalities in the percent delta P/V or delta EF were also seen in 26 of the 53 patients with normal coronary angiograms. Thus, abnormalities in the P/V relationship or EF during exercise are more common than abnormalities in the EF alone. Relative and absolute measurements provide similar results.
Adult↗