Biomedical subjects

J Heppell

Publications and source records attributed to J Heppell.

40 records · Page 3Linked to original sources

PubMed1983

Predicting outcome after endorectal ileoanal anastomosis.

The aim of this study was to determine whether anorectal manometry could predict clinical outcome after closure of a diverting ileostomy made at the time of colectomy, mucosal proctectomy and endorectal ileoanal anastomosis for chronic ulcerative colitis. Twenty-two patients were studied, 6 with ileoanal anastomosis and 16 with ileal pouch-anal anastomosis. Resting anal sphincter pressures and pressure-volume curves (compliance) of the neorectum were assessed before the diverting ileostomy was closed and results were correlated with frequency and leakage of stools 1 month after closure. Before stomal closure, the mean (+/- standard error of the mean) resting sphincteric pressure was 44 +/- 5 cm H2O, while neorectal compliance was 2.3 +/- 0.3 ml/cm H2O. One month later daily stool frequency was 12 +/- 1, while severe leakage occurred in four patients during the day and in eight at night. The greater the sphincteric pressure and the compliance, the fewer were the number of stools per day (p less than 0.01). When pressure and compliance were considered together as an index of anorectal function, the correlation of stool frequency and leakage was even stronger (p less than 0.001). The authors conclude that anorectal manometry can predict early clinical outcome after ileoanal anastomosis.

Adolescent↗

PubMed1982

Physiologic aspects of continence after colectomy, mucosal proctectomy, and endorectal ileo-anal anastomosis.

We examined the physiology of continence in 12 patients at least four months after colectomy, mucosal proctectomy, and endorectal ileo-anal anastomosis for ulcerative colitis and familial polyposis. The mean fecal output (+/-SEM) was 598 +/- 60 gm, passed as 12 +/- 4 movements/24 hr, of which 4 +/- 1 were passed at night. The patients were generally continent during the day and could distinguish gas from stool, but 11 of 12 leaked stools at night. Anal sphincter resting pressures (71 +/- 8 cm H2O) and squeeze pressures (171 +/- 15 cm H2O) of patients were similar to those of ten healthy controls (P greater than 0.05), although the rectal inhibitory reflex was absent in the patients. After operation, the distal bowel had a pressure-volume curve of greater slope (0.15 +/- 0.05 ml/cm H2O) than it had in controls (0.07 +/- 0.01 ml/cm H2O, P less than 0.05) and a lesser maximum capacity (patients, 248 +/- 31 ml; controls, 406 +/- 26 ml; P less than 0.05). The greater the capacity of the neorectum, the fewer was the number of bowel movements/day (r = 0.91, P less than 0.001). We concluded that the operation preserved the anal sphincter, although it decreased the capacity and compliance of the distal bowel and impaired continence.

Adult↗

PubMed1982

Endorectal ileoanal anastomosis.

In 1933, Nissen performed the first ileoanal anastomosis. Since then, ileoanal anastomosis has enjoyed only periodic popularity because numerous postoperative problems, primarily as a result of infection and incontinence, plagued the procedure. In recent reports, however, better postoperative results have been detailed which stem not only from improved surgical technique and better selection of patients but also from increased understanding of the physiologic mechanisms by which fecal continence is achieved. At operation, meticulous hemostasis and asepsis, accurate en bloc mucosal dissection and effective drainage each contribute to good functional results and the minimization of complications. In addition, patients who manifest evidence of dysfunction of anal sphincters, who are elderly or obese or who have Crohn's disease should not be candidates for ileoanal anastomosis. Finally, if the anal sphincters are intact, reliable ileal reservoir function, achieved by passive dilation, balloon distention or surgical construction of a pouch, may be the most important determinate of excellent clinical results after ileoanal anastomosis.

Adult↗

PubMedDate not supplied

[Geriatric digestive surgery. An analysis of 163 cases].

The aim of our study is to analyze the clinical features and outcome of digestive surgery in the aged. From Jan. 1979 to Dec. 1981, 1,389 operations under general anesthesia were performed on patients 75 years old and more. From this group, 163 patients (111 females and 52 males, mean age: 79 +/- 0.7 years) underwent surgery of the alimentary tract. The procedures were divided in: colorectal (48%), biliary (32%), gastric (10%), small bowel (6%), esophagus (1%) and others (3%). An operation for cancer was performed in 63 patients: palliative (69%), curative (31%). The mean length of hospital stay is 23 days (pre-op 7 days, post-op 16 days). Only 16% of the patients needed intensive care. Postoperative complications occurred in 43 patients (26%); cardiovascular (47%), psychiatric (26%), pulmonary (23%) and others (4%). The overall mortality rate is 10%: 6% for elective cases and 24% for urgent cases (49 patients). The mortality is related to: sepsis and peritonitis (53%), cardiopulmonary disease (23%), hemorrhage (12%), cachexia (12%). At discharge, 62% of the patients returned home directly, 18% to convalescent homes, 10% to unknown places and 10% in nursing homes. Our data supports the benefit of surgery in the aged.

Aged↗