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Biomedical subjects

J Hilden

Publications and source records attributed to J Hilden.

15 recordsLinked to original sources
PubMed1979

Sudden infant death in Copenhagen 1956--1971. II. Social factors and morbidity.

131 cases of the Sudden Infant Death Syndrome (SIDS) among infants born in the Municipality of Copenhagen during 1956--1971 were analysed on the basis of data collected prospectively by the infant health visitors and abstracted from police reports. Compared with controls, a significantly larger number of SIDS infants had been born out of wedlock, were living only with their mother, had parents in a less secure occupation, lived in more crowded, poor-quality dwellings and districts. The "home standard" was lower among the SIDS families, including a lower standard of infant care, a higher percentage of not keeping the appointments with the infant health visitors and a lower mental capacity in the mothers; there was no difference with respect to the mother's physical capacity. More congenital malformations and more cases of asphyxia were found among the SIDS infants, and a significantly larger number of the SIDS infants had been admitted to hospital, with a tendency to being kept there longer. It is concluded that a relationships exists between poor social conditions, increased morbidity, and SIDS. At the same time, it is pointed out that during recent years the differences between cases and controls as regards certain of the social parameters studied have decreased.

Congenital Abnormalities↗
PubMed1979

Sudden infant death in Copenhagen 1956--1971. III. Perinatal and perimortal factors.

139 cases of the Sudden Infant Death Syndrome (SIDS) among infants born in the Municipality of Copenhagen during the period 1956--1971 were analysed on the basis of data collected from police reports and (for 131 cases) from the infant health visitors' records. In the SIDS group there was a greater male preponderance than among others dying in the same age range. Compared with the living controls, the SIDS mothers had attended less prenatal examinations, more often delivered their babies at home; the SIDS parents were younger, and yet the SIDS infants were less often firstborns. There was no difference with respect to history of abortions, maternal state of health during pregnancy, or events at delivery. The age at death for the SIDS infants is of a distribution similar to that for fatal respiratory infections. Prematures died later than matures, but this difference is not statistically significant. It is concluded that perinatal factors and SIDS are correlated, but owing to changes in predisposing factors and decreasing differences between cases and controls in recent years as well as interdependence of the factors, it seems doubtful whether the incidence of SIDS can be reduced by alleviating the above-mentioned unfavourable factors.

Abortion, Induced↗
PubMed1978

Sudden infant death in Copenhagen 1956--1971. I. Infant feeding.

131 cases of the Sudden Infant Death Syndrome (SIDS) in the municipality of Copenhagen 1956--71 (incidence 0.92 SIDS cases per 1 000 live births) were investigated on the basis of police reports and infant health visitor's records. Fewer SIDS cases were breast-fed than controls from the second week of life to four months of age. No significant differences were found with respect to the concentrations of fresh cow's milk dilutions, age at introduction of solid food, or number of meals per day. From 1956 to 1971 breast-feeding was declining and solids introduced earlier, while the incidence of SIDS remained constant. The lifespan for SIDS cases who had never been breast-fed was equal to that of cases who had. There is no evidence that SIDS victims had their first solid food during the last days of life. The results are discussed in the light of the hypersensitivity, immuno-incompetence, and high solute feeding hypotheses. It is concluded that feeding does not seem to be responsible for the occurrence of SIDS. The lower frequency of breast-feeding among SIDS cases is ascribed to various factors known to be associated with SIDS.

Age Factors↗
PubMed1976

An interaction between bleomycin and human serum. The reaction of Ehrlich cells and Triticum plant roots to some antineoplastic drugs alone and in combination with human serum.

In two growth tests, one employing EHRLICH ascites tumor cells in suspension culture, the other employing intact roots of wheat (Triticum sativum Lam), the growth inhibiting action of bleomycin (BLM) was shown to be intensified by human serum. Practical consequences of the finding are suggested. No such serum-drug interaction has been demonstrated with other anti-tumor compounds, including methotrexate (MTX) and threosulphan (TRSF). Isolation of the active factor(s) in serum has not yet been attempted.

Animals↗
PubMed1975

The toxicity of human serum against Ehrlich cells--an attempt at characterizing responsible components.

A biochemical characterization of the toxic action of human serum on murine Ehrlich ascites tumor cells was attempted. Some observations are consistent, other inconsistent, with the hypothesis of complement dependent antibodies reacting with ubiquitous antigens on these cells. Studies using various serum fractions, and with pure preparations of human serum proteins, have not given consistent results. Of particular interest is the puzzling observation that the toxic action of human serum fractions sometimes only appears some time after the fractionation.

Animals↗