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Biomedical subjects

J Himle

Publications and source records attributed to J Himle.

7 recordsLinked to original sources
PubMed2000

Action-monitoring dysfunction in obsessive-compulsive disorder.

Evidence suggests that a hyperactive frontal-striatal-thalamic-frontal circuit is associated with the symptoms of obsessive-compulsive disorder (OCD), but there is little agreement about the function of the exaggerated activity. We report electrophysiological evidence suggesting that part of this system monitors events and generates error signals when the events conflict with an individual's internal standards or goals. Nine individuals with OCD and 9 age-, sex-, and education-matched control participants performed a speeded reaction time task. The error-related negativity, an event-related brain potential component that reflects action-monitoring processes, was enhanced in the individuals with OCD. The magnitude of this enhancement correlated with symptom severity. Dipole modeling suggested that the locus of the enhancement corresponded to medial frontal regions, possibly the anterior cingulate cortex.

Adult↗
PubMed1998

Comparing virtual and real worlds for acrophobia treatment.

Traditional treatment of phobias involves a process of gradual exposure to the feared object. Virtual Reality (VR) environments have been used to effectively treat phobias by simulating feared situations, yet these initial studies have been performed by comparing the effect to no-treatment conditions. We are in the process of comparing VR exposure treatment to "gold-standard" in-vivo exposure treatment by replicating an actual in-vivo exposure area in a VR model. The process of controlling for differences between the two environments highlights a general procedure of selecting elements in virtual environment design, targeted towards producing particular emotional effects. It also raises questions about the necessity for highly realistic simulation in VR phobia treatment.

Behavior Therapy↗
PubMed1989

Clinical social work and obsessive compulsive disorder. A single-subject investigation.

Clinical research on the purely obsessional patient is considerably less developed than that for compulsive ritualizers or obsessive compulsives with mixed features. A single case investigation of exposure therapy in the treatment of obsessive ruminations is presented. Treatment involved exposing the patient to a variety of stimuli related to obsessional thoughts including reading, writing, and listening to such content. The patient's immediate response to treatment was favorable, with improvements being maintained at two-year follow-up.

Behavior Therapy↗
PubMed1985

Blood-injury-illness phobia: a review.

The empirical literature that pertains to phobias of blood, injury, or illness (BII) is surveyed. BII phobia is selectively associated with a vasovagal fainting response upon exposure to phobic stimuli, and the clinical entity may represent an exaggeration of a response that is relatively prevalent in the general population. Clinical, demographic and etiological information obtained from a series of 15 BII phobics is presented, and the suggestion is made that this disorder warrants a diagnostic category separate from simple phobia.

Adolescent↗