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Biomedical subjects

J Hofman

Publications and source records attributed to J Hofman.

At least 19 recordsLinked to original sources
PubMed2003

Fluticasone propionate in asthma: a long term dose comparison study.

BACKGROUND: Few dose ranging studies have investigated optimal dosing with inhaled corticosteroids in children with asthma. AIMS: To compare the efficacy and tolerability of fluticasone propionate 100 or 200 microg twice daily in children with moderate to severe asthma for one year. METHODS: One year, randomised, double blind, parallel group, multicentre study. Children aged 4-11 years (n = 528) with moderate to severe asthma who had previously received high dose inhaled corticosteroids were given fluticasone propionate 100 or 200 microg twice daily for the 52 week treatment period. Efficacy (exacerbations, lung function, and symptoms) and tolerability (adverse events and cortisol levels) were measured. RESULTS: There was a non-significant decreased risk of experiencing an exacerbation at any time with fluticasone propionate 200 microg twice daily compared with fluticasone propionate 100 microg twice daily. This difference reached significance among patients with more severe asthma (defined by previous inhaled corticosteroid dose >800 microg/day). Daily record card morning peak expiratory flow (PEF) in the total population improved significantly more with the higher dose of fluticasone propionate (between group difference, weeks 1-52: 11.4 l/min). Clinic visit mean PEF improved from baseline with both doses, but the response was significantly greater with the higher dose (between group difference, week 52: 17.8 l/min). Both doses were equally well tolerated and overnight urinary cortisol concentrations were unchanged or slightly increased during treatment with either dose. CONCLUSION: This long term dose comparison study shows that treatment with fluticasone propionate 200 micro g twice daily may offer benefits over a lower dose, particularly in children with more severe asthma.

Androstadienes↗
PubMed1996

Predictors of pulse oximetry data failure.

BACKGROUND: Pulse oximeters have been reported to fail to record data in 1.12-2.50% of cases in which anesthesia records were handwritten. There is reason to believe that these may be underestimates. Computerized anesthesia records may provide insight into the true incidence of pulse oximetry data failures and factors that are associated with such failures. METHODS: The current study reviewed case files of 9,203 computerized anesthesia records. Pulse oximetry data failure was defined as the presence of at least one continuous gap in data > or = 10 min in duration in a case. A multivariate logistic regression model was used to identify predictors of pulse oximetry data failure, and a modified case-control method was used to determine whether extremes of blood pressure and hypothermia during the procedure were associated with pulse oximetry data failure. RESULTS: The overall incidence of cases that had at least one continuous gap of > or = 10 min in pulse oximetry data was 9.18%. The independent preoperative predictors of pulse oximetry data failure were ASA physical status 3,4, or 5 and orthopedic, vascular, and cardiac surgery. Intraoperative hypothermia, hypotension, hypertension, and duration of procedure were also independent risk factors for pulse oximetry data failure. CONCLUSIONS: Pulse oximetry data failure rates based on review of computerized records were markedly greater than those previously reported. Physical status, type of surgery, and intraoperative variables were risk factors for pulse oximetry data failure. Regulations and expectations regarding pulse oximetry monitoring should reflect the limitations of the technology.

Humans↗
PubMed1995

[Introductory clinical evaluation of fluticasone propionate efficacy for treatment of allergic rhinitis in children].

The investigations were carried out on 13 children with seasonal rhinitis, and in 10 children with perennial rhinitis. The fluticasone propionate (Flixonase-Glaxo) was introduced in acute state of disease: one dose to each nostril (100 micrograms) for the patient 7-11 years old, and in the patients under 11 years old--two doses to each nostril (200 micrograms) in the morning, during 3 weeks. The clinical effects were established using score-system in 0-3 points scale which included essential symptoms like: itching, sneezing, nasal blockade, rhinorrhoea, mucosal oedema and eyes irritation. Very good and good effects of the treatment in patients with seasonal rhinitis in 93% of children was observed. In the group of patients with perennial rhinitis, very good and good results, was observed in 80% of children. Easy dosage, high efficacy, very nice smell and no side-effects make this medicine very usefull in the treatment of allergic rhinitis in children.

Adolescent↗
PubMed1995

Allergic constitution and immunological condition of children infected with giardia lamblia.

In the group of 81 children infected with Giardia lamblia, the chosen parameters of cellular and humoral immunity as well as the effect of allergic costitution on the clinical picture of giardiasis were evaluated. Both cellular and humoral immunity disorders were found in patients with a chronic form of infestation. An allergic constitution coexisting with giardiasis promotes the chronicity of this parasitosis and a progressing allergization.

Adolescent↗
PubMed1995

Clinical effects of specific immunotheraphy in children with atopic dermatitis.

The clinical results of specific immunotheraphy using Pollinex, Catalet, or Alavac S-HDM vaccines in 22 patients with atopic dermatitis are presented. The immunotheraphy in children with allergy to Dermatophagoides lasted for about 3 years and in children allergic to pollen grass antigens 3 pollen seasons. In the group of children submitted to specific immunotheraphy with Dermatophagoides antigens very good and good results after 3 years of treatment were observed in 75% of patients. In the patients treated with grass pollen antigens Catalet or Pollinex very good and good results were noted in 83% and 80% patients respectively. Our investigation showed, that specific immunotheraphy should be taken into consideration in the treatment of atopic dermatitis in carefully selected cases of children allergic to both grass pollen and Dermatophagoides allergens.

Adolescent↗
PubMed1994

Major and minor surgery at a rural African hospital.

Surgical operations performed at Ombo Hospital in Western Kenya from January to December 1989 were studied and annual surgical rates were calculated based on the estimated catchment area population. The total annual rate of major surgery at this church-supported hospital was 207 operations per 100,000 people. This rate is similar to those at other East African hospitals while rates in industrialized countries are 20-35 times higher. The most common major procedures were Caesarean section, laparotomy, hernia repair and salpingectomy. The 1989 rate of minor operations at the hospital was 1286 per 100,000 people with tooth extraction, wound suture, incision and drainage, evacuation of the uterine cavity and closed reduction of fracture as the most frequent procedures. Major operations were performed exclusively by doctors while minor surgery was carried out mainly by clinical officers, nurses and other auxiliary staff.

Adolescent↗
PubMed1992

[Difficulties in diagnosis of rhinitis in children treated at the Otorhingologic outpatient department of children's hospital in Bialystok].

The aim of this study was an analysis of rhinitis etiology in 105 children treated in Otorhinolaryngology Outpatients Department, Children Clinical Hospital in Białystok. In 58 patients seasonal allergic rhinitis, stimulated by grass antigens, in 37 patients infectious rhinitis and in 10 patients perennial allergic rhinitis stimulated by mites was recognised. The diagnosis in this last group was made using laryngological investigations skin "prick tests" and specific IgE level against mites.

Adolescent↗
PubMed1991

[Influence of muscarinic receptors and calcium channel blockers on bronchial reactivity and ventilation parameters in patients with obstructive lung diseases].

In 9 patients with obstructive lung disease as influence of ipratropium bromide (Atrovent) - muscarine receptors blocker and verapamil - calcium channel blocker on bronchial reactivity was evaluated. In the study was documented that verapamil decreased the bronchial reactivity and didn't change static ventilation parameters. Atrovent in observed patients improved their ventilation. On the other hand, verapamil didn't change a mode and efficiency of Atrovent action.

Bronchial Hyperreactivity↗