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Biomedical subjects

J Hollenberg

Publications and source records attributed to J Hollenberg.

11 recordsLinked to original sources
PubMed2005

Difference in survival after out-of-hospital cardiac arrest between the two largest cities in Sweden: a matter of time?

BACKGROUND: Dramatic differences in survival after out-of-hospital cardiac arrests (OHCA) reported from different geographical locations require analysis. We therefore compared patients with OHCA in the two largest cities in Sweden with regard to various factors at resuscitation and outcome. SETTING: All patients suffering an OHCA in Stockholm and Goteborg between 1 January 2000 and 30 June 2001, in whom cardiopulmonary resuscitation (CPR) was attempted were included in this retrospective analysis. RESULTS: All together, 969 OHCA in Stockholm and 398 in Goteborg were registered during the 18-month study period. There were no differences in terms of age, gender, and percentage of witnessed cases or percentage of patients who had received bystander CPR. However, the percentage of patients with ventricular fibrillation (VF) at arrival of the ambulance crew was 18% in Stockholm versus 31% in Goteborg (P <0.0001). The percentage of patients who were alive 1 month after cardiac arrest was 2.5% in Stockholm versus 6.8% in Goteborg (P=0.0008). Various time intervals such as cardiac arrest to calling for an ambulance, cardiac arrest to the start of CPR and calling for an ambulance to its arrival were all significantly longer in Stockholm than in Goteborg. CONCLUSION: Survival was almost three times higher in Goteborg than in Stockholm amongst patients suffering an OHCA. This is primarily explained by a higher occurrence of VF at the time of arrival of the ambulance crew, which in turn probably is explained by shorter delays in Goteborg. The reason for the difference in time intervals is most likely multifactorial, with a significantly higher ambulance density in Goteborg as one possible explanation.

Age Distribution↗
PubMed2001

Can physicians' admission evaluation of patients' status help to identify patients requiring social work interventions?

OBJECTIVE: To evaluate the utility of these physicians' initial clinical assessments in identifying patients admitted from their homes who subsequently require social work intervention for discharge planning. DESIGN: Retrospective chart review of discharge disposition correlated with a prospective physician evaluation of patients. SETTING: An academic medical center. PARTICIPANTS: Consecutive patients, (2,571) men and women, admitted at the New York Hospital between July 1, 1997 and October 31, 1997. MEASUREMENT: Prospective evaluation of clinical status, functional status, illness severity and stability by physicians within 24 hours of admission. RESULTS: Older patients, sicker and less functional, have higher needs for social work intervention (P < 0.001). New nursing home placement patients were older and had worse function (P < 0.001). Total cost of hospitalization and length of stay were predicted by discharge disposition. CONCLUSION: Early discharge intervention has often been targeted as a potential mechanism to lower hospitalization cost and reduce length of stay. Age and physician evaluation of functional status at admission may provide early identification of those who require social work assistance.

Academic Medical Centers↗
PubMed2000

Quality of life of homeless persons with mental illness: results from the course-of-homelessness study.

OBJECTIVE: The quality of life of homeless persons with mental illness was compared with that of homeless persons without mental illness. METHODS: Subjective and objective quality-of-life ratings were obtained in face-to-face interviews with 1,533 homeless adults in Los Angeles, who were identified using probability sampling of people on the streets and at shelters and meal facilities; 520 subjects were tracked for 15 months. Ratings of homeless persons with and without mental illness were compared using chi square tests and regression analyses. RESULTS: Mentally ill homeless persons were significantly more likely than those without mental illness to receive Supplemental Security Income, Social Security Disability Insurance, Veterans Affairs disability benefits, or Medicaid. However, those with mental illness still fared significantly worse in terms of physical health, level of subsistence needs met, victimization, and subjective quality of life. Differences between groups in the subjective quality-of-life ratings were accounted for by modifiable factors such as income and symptoms rather than by nonmodifiable demographic characteristics. CONCLUSIONS: Interventions most likely to improve the quality of life of homeless persons with mental illness include those that stress maintenance of stable housing and provision of food and clothing and that address physical health problems and train individuals to minimize their risk of victimization. Interventions that decrease depressive symptoms might also improve subjective quality of life.

Adult↗
PubMed1999

Randomized trial of hypotensive epidural anesthesia in older adults.

BACKGROUND: Data are sparse on the incidence of postoperative cognitive, cardiac, and renal complications after deliberate hypotensive anesthesia in elderly patients. METHODS: This randomized, controlled clinical trial included 235 older adults with comorbid medical illnesses undergoing elective primary total hip replacement with epidural anesthesia. The patients were randomly assigned to one of two levels of intraoperative mean arterial blood pressure management: either to a markedly hypotensive mean arterial blood pressure range of 45-55 mmHg or to a less hypotensive range of 55-70 mmHg. Cognitive outcome was assessed by within-patient change on 10 neuropsychologic tests assessing memory, psychomotor, and language skills from before surgery to 1 week and 4 months after surgery. Prospective standardized surveillance was performed for cardiovascular and renal outcomes, delirium, thromboembolism, and blood loss and replacement. RESULTS: The two groups were similar at baseline in terms of age (mean, 72 yr), sex (50% women), comorbid conditions, and cognitive function. After operation, no significant differences in the incidence of early or long-term cognitive dysfunction were observed between the two blood pressure management groups. There were no significant differences in the rates of other adverse consequences, including cardiac, renal, and thromboembolic complications. In addition, no differences occurred in the duration of surgery, intraoperative estimated blood loss, or transfusion rates. CONCLUSIONS: Elderly patients can safely receive controlled hypotensive epidural anesthesia with this protocol. There was no evidence of greater risks, or early benefits, with the use of the more markedly hypotensive range.

Aged↗
PubMed1997

Validation of the Panic Outcomes Module.

This article discusses the validation of a module designed to evaluate the outcomes of clinical care for panic disorder. The research utilized a longitudinal design to examine cross-sectional relationships and change over time within and between subjects. Baseline, follow-up, and test-retest data were collected on 73 patients. The initial field test indicates that the Panic Outcomes Module measures outcomes and case-mix characteristics with acceptable levels of measurement error for group data. The module's measure of change in panic severity demonstrated encouraging agreement with the structured interviewer's judgement of change. This module, completed in approximately 20 minutes, is short enough to incorporate into outpatient mental health settings. We recommend that providers and administrators interested in monitoring the outcomes of specialty care for panic disorder seek assistance from health services researchers to use the Panic outcomes module. Further research is needed to validate this module for use in primary care populations.

Adult↗
PubMed1997

Effectiveness of care and improvement of quality of life in patients with panic disorder.

To investigate how practice guidelines or recommendations can be applied in the assessment of quality of care, 72 subjects beginning specialty treatment for panic disorder were enrolled. The Panic Outcomes Module assessed symptoms, health status, and treatment at baseline and after 8 weeks. Using published guidelines, the authors developed specific criteria to rate whether subjects' reports reflected appropriate treatment, including antipanic medication or three or more subsequent visits that involved antipanic behavioral therapy elements. Sixty-nine subjects (96%) completed the Panic Outcomes Module at both baseline and follow-up. Improvement in symptoms and health status was not different between subjects receiving appropriate and inappropriate care.

Adolescent↗
PubMed1996

Onset of physical abuse and neglect: psychiatric, substance abuse, and social risk factors from prospective community data.

Studies of psychiatric and social risk factors for child maltreatment have been limited by retrospective methodologies and reliance on officially reported or identified samples. Using data from both Waves I and II of the National Institute for Mental Health's Epidemiologic Catchment Area survey, 7,103 parents from a probabilistic community sample who did not self-report physical abuse or neglect of their children at Wave I were followed to determine the risk factors associated with the onset of self-reported physical abuse or neglect identified at Wave II. Social factors considered included age, socioeconomic status, social support, education, household size, and gender. In addition, several psychiatric disorders, including substance abuse disorders and depression were examined. Risk models were developed using hierarchical logistic regression. Physical abuse and neglect were found to have distinct sets of risk factors, with minimal overlap between the groups. Social and demographic variables were found to be limited predictors of maltreatment, while substance abuse disorders were strongly associated with the onset of both abuse and neglect (relative risks = 2.90 and 3.24 respectively). Depression was found to be a strong risk factor for physical abuse (relative risk = 3.45). Implications of the findings are discussed in terms of major causal models of maltreatment.

Adult↗
PubMed1994

Alcohol and drug disorders among physically abusive and neglectful parents in a community-based sample.

OBJECTIVES: The purpose of this study was to compare the frequency of substance use disorders and symptoms between adults reporting child physical abuse or neglect and individually matched control subjects in a community sample. METHODS: In a nested case-control study, 169 adults reporting physical abuse of a child and 209 adults reporting neglect of a child from 11,662 individuals successfully interviewed in a probabilistic survey in four communities were individually matched with control subjects drawn from the participants. Case subjects were compared with control subjects on the number of alcohol- or drug-related symptoms and disorder diagnoses as determined by symptoms from the Diagnostic Interview Schedule. RESULTS: Respondents reporting either physical abuse or neglect of children were much more likely than their matched control subjects to report substance abuse or dependence. These differences persisted after potential confounding variables were controlled for. CONCLUSIONS: Parental substance abuse and dependence, independent of confounding factors, are highly associated with child maltreatment. Inconsistent results in previous studies may have arisen from reliance on referred samples and unstandardized assessment methods. Agencies involved in the care of abused or neglected children and their families should consider incorporating routine substance abuse evaluations with treatment, or referral for treatment, where indicated.

Adult↗
PubMed1976

Kinematic effects of deafferentation and cerebellar ablation.

Trajectories of hand movements directed visually toward a stationary target were compared by kinematic methods in control monkeys, those with bilateral upper limb deafferentation, those with cerebellar ablation and those with both these lesions. The purpose of the investigation was to determine whether: (1) deafferented animals display kinematic abnormalities similar to those of decerebellate animals, and (2) a combination of these two lesions results in cumulative motor disorders. The decerebellate preparation had significant increases of the ratio of path length to target distance, mean deviation from a straight line path, segment angle (average change in direction between successive segments of the trajectory), target angle (average angle between the path taken by the hand and a straight line path to the target), peak velocity, average acceleration and peak acceleration. The deafferented preparation had increases of these parameters significantly greater than the decerebellate preparation. Neither preparation showed abnormalities of average linear velocity. The deafferented preparation rendered decerebellate had significant additional increases in all parameters except average segment angle, an index of angular velocity. Scatter plots of acceleration versus velocity and of segment angle versus target angle revealed increasing dispersion in the sequence: control, decerebellate, deafferented, deafferented with subsequent cerebellar ablation. The quantitative demonstration of cumulative worsening of motor performance when the deafferented animal is rendered decerebellate indicates that there are mechanisms of cerebellar dysmetria independent of the fusimotor efferent-spindle afferent reflex arc.

Afferent Pathways↗
PubMedDate not supplied

Comparison of different treatment strategies for diffuse large-cell lymphomas: a decision analysis.

There are more than 20 drug combinations in use for the treatment of diffuse large-cell non-Hodgkin's lymphoma (NHL). New treatments have been developed without prior comparison in clinical trials. The authors devised a Markov-process model to compare the efficacy of a first-generation combination chemotherapy regimen (CHOP) with that of a third-generation regimen (MACOP-B) using currently available data. For a typical 57-year-old male patient, life expectancy with MACOP-B was 12.1 years, compared with 8.3 years with CHOP. The remission rate after initial treatment and the functional status after the first remission is achieved were the most important determinants of life expectancy. It was still possible for CHOP to become better strategy provided that the initial remission rate with MACOP-B were lower than 50% or that functional status after remission was achieved were less than 66%. The analysis suggests that the most effective therapeutic regimen for diffuse large-cell lymphoma must not only result in a high remission rate but also cause minimal late sequelae. These two parameters were incorporated into the nomogram, which can serve as a basis for comparison of the efficacy of any chemotherapeutic regimen in non-Hodgkin's lymphoma.

Antineoplastic Combined Chemotherapy Protocols↗