Biomedical subjects
Publications and source records attributed to J Holub.
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Neutral 8-(5-iodo-n-pentyl)-3-(eta(5)-pentamethylcyclopentadienyl)-arachno-3-rhoda-7,8-dithiaundecaborane, [Rh(C(5)H(19)B(8)IS(2))(C(10)H(15))], obtained from the [arachno-7,8-S(2)B(9)H(10)](-) anion by treatment with I(CH(2))(5)I followed by [Rh(C(5)Me(5))Cl(2)](2) and N,N,N',N'-tetramethyl-1,8-diaminonaphthalene, has the 11-vertex cluster geometry of [arachno-7,8-S(2)B(9)H(10)](-), but with an [Rh(C(5)Me(5))] unit in the 3-position instead of a [BH] unit, and with a -(CH(2))(5)I chain attached exo to an S atom.
The reaction between the carborane arachno-4,6-C2B7H13 (1) and PCl3 in dichloromethane in the presence of a "proton sponge" (PS = 1,8-dimethylaminonaphthalene) resulted in the isolation of the eleven-vertex nido-diphosphadicarbaboranes 7,8,9,11-P2C2B7H, (2) and 3-Cl-7,8,11-P2C2B7H, (3-Cl-2) in yields of 54 and 7%, respectively. Replacement of the PS by NEt3 in the same reaction gave diphosphadicarbaboranes 2 and 3-CI-2 together with the isomeric species nido-7,9,8,10-P2C2B7H, (3) in yields of 28, 15 and 3%, respectively. The reaction between the isomeric carborane arachno-4,5-C2B7H13 (4) and PCl3 in dichloromethane in the presence of PS gave the asymmetrical isomer, nido-7,8,9,10-P2C2B7H, (5). along with the chloro derivatives 4-Cl-7,8,9,10-P2C2B7H8 (4-Cl-5) and 11-Cl-7,8,9,10-PC2B7,H8 (11-Cl-5) (yields of 21, 1 and 13%, respectively). The structures of the chlorinated derivatives 3-Cl2 and 11 -Cl-5 were determined by X-ray diffraction analysis. In addition, the structures of all compounds isolated were geometry-optimised and confirmed by comparison of experimental 11B chemical shifts with those calculated by the GIAO-SCF/II//RMP2(fc)/6-31G* method. The calculations also include the structure and 11B NMR shifts of the isomer nido-7,10,8,9-P2C2B7H9 (6) which has not yet been isolated.
Treatment of the zwitterionic amine tricarbollides of general formula 7-L-nido-7,8,9-C3B8H10 (1) (where L = Me2HN (1c) and ButH2N (1d)) with [(eta 5-C5H5)Fe(CO)2]2 in refluxing mesitylene resulted in the formation of a mixture of the known compounds [2-(eta 5-C5H5)-9-X-closo-2,1,7,9-FeC3B8H10] (2) (where X = H2N (2a), Me2N (2c), and ButHN (2d)) and a series of new, isomeric ferratricarbollylamines [2-(eta 5-C5H5)-10-X-closo-2,1,7,10-FeC3B8H10] (3) (where X = H2N (3a), Me2N (3c), and ButHN (3d)) in moderate yields. Complexes of type 3 (where X = H2N (3a), MeHN (3b), Me2N (3c), and ButHN (3d)) were also obtained readily by heating complexes of type 2 (where X = H2N (2a), MeHN (2b), Me2N (2c), ButHN (2d), and Bu(t)(Me)N (2e)) at ca. 300 degrees C for 10 min. All the complexes of type 3 contain reactive amine functions in meta positions with respect to the metal center. The observed 9-->10 rearrangement of the substituted cluster carbon is quite unexpected and is believed to result from higher thermodynamic stability of the 10-substituted isomers. The structures of all compounds of type 3 were established by high-field NMR spectroscopy and mass spectrometry, and that of 3d was determined by an X-ray diffraction study.
The title compound, 1,1,2,2-tetracarbonyl-1,2-&mgr;-carbonyl-4, 11-dimethylsulfido-closo-1,2-dicobaltadodecaborane, [Co(2)(C(4)H(20)B(10)S(2))(CO)(5)], has a closo 12-vertex 1, 2-Co(2)B(10)H(8) structure with SMe(2) ligands at the exo-4- and 11-positions. The cluster displays close structural similarities to the SEt(2) analogue.
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The high percentage of hospitalized pregnant women in the Czech Republic was analyzed form the cost benefit aspect within the framework of the current transformation of the health services which restricts in-patient care in favour of ambulatory care, as part of the developing market economy. Two internationally accepted indicators of quality of perinatal morbidity-maternal (rate of eclampsia) as well as neonatal (rate of low birth weight infants), i.e. partially preventable prenatal hospitalizations. In a comparative epidemiological study the incidence of these indicators in the Czech Republic was compared with the incidence in Hessen where there is a lower rate of prenatal hospital admissions, while there is a similar system of perinatal care and general perinatal mortality. In the Czech Republic where the cost of hospitalization of pregnant women is higher, the authors found as regards the benefit a lower incidence of the mentioned two indicators and from the economic aspect a lower cost of neonatal intensive care than in Hessen. This saving was fourfold as compared with the higher costs of prenatal hospitalization.
The authors evaluate the method applied in an extensive investigation of the general morbidity of the Czech population implemented in 1986, based on treated morbidity, not combined with the method of actual medicinal examinations. The population sample was selected by one-stage selection, randomization was made by birth data (seventh day in odd month). In the investigation participated all health community and factory doctors, as well as paediatricians and adolescent medical officers in the Czech Republic. Morbidity was assessed retrospectively from the documentation of health community doctors. The investigation confirmed the hypothesis that this method can be used under local conditions for periodic examinations of the general morbidity of the population.
The authors draw attention to the increasing work incapacity on account of dorsopathies. They analyzed their prevalence in 1980-1985 in different trade union branches. The revealed differences call for further investigations of the problem in a systemic manner.
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Explore the source record for details and available documents.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.