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Biomedical subjects

J Homik

Publications and source records attributed to J Homik.

11 recordsLinked to original sources

[The effect of location and shape of the fracture line on results of conservative treatment of closed tibial shaft fractures].

One hundred seventy five closed crural shafts fractures have been analysed. They have been classified depending on the location and shape of the fracture line. Clinical and radiological assessment were taken into consideration. The best final results have been achieved in fractures of middle third of the tibia and in fractures of transverse fracture line. The disturbances of bone union most often occurred between middle and distal third of the tibia and transverse fractures.

Fractures, Closed

[Use of supra-malleolar traction in treatment of closed fractures of the crural shafts].

The results of treatment of 36 closed fractures of the crural shafts reduced with supra-malleolar traction have been presented and evaluated with own scale. The best results were achieved with traction maintained for 5-6 weeks. Most of the failures were due to the disturbed union and restricted range of movement in the ankle. The authors conclude, that traction prevents secondary displacement and should be recommended for treatment of unstable fractures of the crural shafts.

Ankle Joint

Reversible interleukin-2 response defects in systemic lupus erythematosus.

Limiting dilution analysis techniques were used to determine precursor frequencies for interleukin-2 (IL-2) responsive cells among the peripheral blood lymphocytes of patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis compared with healthy subjects. Response defects in SLE were found, but were of two types: reduced precursor frequencies with normal pattern of response (single-hit kinetics); and abnormal multi-hit responsiveness. These abnormalities were not more frequent statistically in those with active disease. Precursor frequencies of SLE peripheral blood lymphocytes were enhanced by resting the cells for up to 72 h prior to activation, and by adding exogenous IL-2 during the initial activation step. The IL-2 response defects of SLE are therefore reversible and may in part be secondary to other in vivo abnormalities, such as deficient IL-2 production.

Cells, Cultured