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Biomedical subjects

J Homola

Publications and source records attributed to J Homola.

17 recordsLinked to original sources
PubMed2003

Hemostyptic effect of oxidized cellulose on blood platelets.

Cellulose is one of the hemostyptic biomaterials, which are able to initiate or accelerate blood coagulation at the site of their application. It belongs to surgical sealants. The mechanism of its action is not clearly understood. We studied the participation of blood platelets in this mechanism. As a marker of platelet activation we used serotonin release reaction. Serotonin release in platelet rich plasma incubated with various concentrations of oxidized cellulose (0.5%-2.0%) started in about 20 min. Washed platelets were not directly activated by oxidized cellulose within one hour. Washed platelets reconstituted in plasma obtained from two patients with coagulation factor XII deficiency were activated by oxidized cellulose with a prolonged lag phase. Our results demonstrate the significant influence of factor XII on blood platelets activation by oxidized cellulose.

Blood Coagulation↗
PubMed2002

A miniature fiber optic surface plasmon resonance sensor for fast detection of Staphylococcal enterotoxin B.

A fiber optic surface plasmon resonance (SPR) biosensor for detection of Staphylococcal enterotoxin B (SEB) is reported. The sensor is based on spectral interrogation of surface plasmons in a miniature sensing element based on a side-polished single-mode optical fiber with a thin metal overlayer. For specific detection of SEB, the SPR sensor is functionalized with a covalently crosslinked double-layer of antibodies against SEB. The SPR biosensor is demonstrated to be able to detect ng/ml concentrations of SEB in less than 10 min.

Enterotoxins↗
PubMed1997

[Are echogenic foci in fetal heart ventricles insignificant findings?].

In a group of 7,721 foetuses with a high or low risk of cardiovascular pathology of the foetus, examined by complete foetal echocardiography, the authors found hyperechogenic ventricular structures in 211 foetuses (2.73% of the group) with a dominating localization in the left ventricle (97%). These structures are in the great majority a benign development variant which involves no risk for the development of the foetus. Rare localization beyond the left ventricle were not risk for the development of the foetus. Rare localization beyond the left ventricle were not associated with cardiac or other foetal pathologies. Echogenic ventricular focuses were not visualized by transvaginal echocardiography in the 13th week of pregnancy, although they were revealed in the same patient during the 21st week. Their presence does not affect left ventricular function and the function of the mitral valve pre-or postnatally. In the differential diagnosis these structures must be always differentiated from thrombi or cardiac tumours.

Echocardiography↗
PubMed1996

[Prenatal cardiology--current problems and the future].

The author evaluates the past development, contemporary problems and future trends in the sphere of prenatal cardiology. As a basis he uses his own ten-year experience at a regional department of prenatal cardiology. He seeks the reasons for the stagnating, relatively low effectiveness of prenatal ultrasonic diagnostic screening to detect serious inborn heart disease which is one of the most frequent inborn foetal defects. The author discusses the association of this phenomenon with transformation changes of the system of health services. He deals with the approach of the child cardiologist to the parents of the affected foetus, possible pharmacological and non-pharmacological therapeutic approaches to prenatal cardiac pathology. It may be assumed that future progress of ultrasonographic technique will open the road from secondary to primary prevention of inborn heart disease.

Echocardiography↗
PubMed1993

[Transvaginal echocardiography in the early diagnosis of congenital heart defects in the human fetus].

Transvaginal echocardiography makes it possible to diagnose serious congenital heart disease already during the first trimester of pregnancy. The authors present their experience with this examination method in pregnant women with a high risk of foetal cardiopathies and in women whose foetus is affected by another serious organ anomaly. The authors evaluate the successful visualization of the cardiac anatomy in different projections in relation to foetal age. They present the diagnosis of a serious inborn heart disease detected during the 15th week of gestation.

Echocardiography↗
PubMed1992

[Normal values of one-dimensional echocardiography of the heart ventricles in the fetus during the 18th to 38th week of pregnancy].

The authors report normal values of one-dimensional echocardiography of the ventricles of foetuses obtained by analysis of high-standard 105 M-mode records of physiological foetuses aged 18-38 weeks. They assume their practical application by gynaecologists and child cardiologists during ultrasonographic screening of foetal pathology of the cardiovascular system.

Echocardiography↗
PubMed1991

[Regional differences in the prevalence of congenital heart defects].

Prevalence of congenital heart diseases was studied prospectively in all 664,218 infants live born in Bohemia from 1977 to 1984. All children who died were autopsied and those suspected of having a heart disease were examined at the specialized center. In total, 664/100,000 infants were born with a heart defect, most of them in Prague (957,9/100,000) and in Central Bohemia (739.4) and in Northern Bohemia (619.3). The lowest prevalence was found in West Bohemia (515.1/100000 live births). The relative frequency of congenital heart defect categories differed significantly among regions. Evidence of regional differences in prevalence of congenital heart diseases and their forms suggests that environmental factors can play an important role in the etiology of congenital heart defects.

Czechoslovakia↗
PubMed1989

[The incidence of heart defects in children].

By examining all of 91,823 children born in 1980 in Bohemia, congenital heart disease was proved in 589 (6.415/1000 liveborns) and cardiomyopathy in 24 (0.261/1000 liveborns). Further 166 (1.808/1000 liveborns) were follow-up with a diagnosis of congenital heart disease by pediatric cardiologists in the field, but at the age of 4 years we didn't prove the defect any more. Prevalence of heart defects: ventricular septal defect (31.4%), atrial septal defect (11.4%), aortic stenosis (7.6%), pulmonary stenosis (7.1%), coarctation of the aorta (5.8%), transposition of the great arteries (5.4%), patent ductus arteriosus (4.8%), atrioventricular canal and hypoplastic left heart (4.1%), tetralogy of Fallot (3.6%). Other defects occurred less frequently than in 2.5% of all congenital heart disease.

Child, Preschool↗
PubMed1989

[Tumor of the left atrium and supraventricular tachycardia in the fetus--prenatal diagnosis and treatment].

During the 29th week of gestation the authors diagnosed supraventricular tachycardia of the foetus and pathological echogenity in the region of the mitral valve, most probably of tumourous aetiology. By transplacental digitalization the supraventricular tachycardia was controlled; according to Doppler analysis the tumour did not interfere with the flow to the mitral orifice. Post-natally the diagnosis of a tumour in the left atrium was confirmed. Surgery was so far postponed in view of the normal haemodynamics.

Adult↗