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J Hucke

Publications and source records attributed to J Hucke.

At least 19 recordsLinked to original sources
PubMed2006

Post-hoc analysis on the CD14 C(-260)T promoter polymorphism and coronary heart disease.

Functional C(-260)--> T polymorphism in the promoter of the CD14 gene has been reported to be associated with coronary heart disease (CHD). The functional role of the polymorphism, however, is still a matter of debate, since several studies have not proved its effect on clinical outcomes associated with atherosclerosis. Cardiovascular-related morbidity and mortality was assessed in a post-hoc approach four years after baseline characterization of patients (male/female n = 36/32) with angiographically proven coronary heart disease. CD14 C(-260)--> T promoter genotype was determined at baseline. Seventeen out of 20 CHD patients with non-lethal cardiovascular events carried at least one T-allele. CD14 T-260 allele carriers have a 3.59-fold (95 % confidence interval: 1.11-6.75) increased risk for non-lethal cardiovascular events (Kaplan-Meier plot: log rank test p = 0.029). All patients with lethal outcomes (n = 6) were also T-allele carriers. Multivariate logistic regression analysis among CHD patients including age, established risk factors and the C(-260)--> T polymorphism as covariates and non-lethal events as a dependent variable confirmed the independent prospective effect of the T-allele on cardiovascular outcomes in this subset. Further evidence is provided for the role of CD14 C(-260)--> T promoter polymorphism as a genetic susceptibility marker of atherosclerosis in patients with an advanced clinical course of the disease. Due to the small sample size and post-hoc character of the study large-scale prospective studies that monitor patients with proven CHD are needed to confirm these findings.

Aged↗
PubMed2000

Hysteroscopy in infertility--diagnosis and treatment including falloposcopy.

Diagnostic hysteroscopy should be included routinely in the work-up of invasive examinations for infertility patients. Anyhow, one can rarely expect to find the definite underlying reason for infertility. In infertile patients about 20% of hysteroscopic examinations show some grade of intrauterine abnormalities. Congenital uterine malformations are the most frequently found disorders. In the group of patients with habitual abortions abnormalities are found much more often and can also be more often interpreted as the mainly underlying factor for the repeated abortions. Operative hysteroscopy has become the surgical method of first choice for the treatment of uterine septa, submucous myomas, polyps and synechia. After septum dissection results are excellent. Myoma removal also shows beneficial effects on fertility; nevertheless, cases are not too frequent among infertility patients. In cases of high-grade Asherman's syndrome, the prognosis after hysteroscopic surgery is still often poor.

Abortion, Habitual↗
PubMed1998

Interstitial pregnancy treated with local and systemic methotrexate.

We present a case of an intact interstitial pregnancy at 6 postmenstrual weeks and 4 days, which was successfully treated by combined local and systemic methotrexate administration. The embryonic cardiac activity stopped within 1 min after uneventful ultrasound-guided puncture and methotrexate instillation of the chorionic sac. While the beta-hCG serum values returned to normal 59 days after local, and 52 days after systemic treatment, the echogenic lesion has reduced in size by 50%, but is still sonographically detectable 7 months after the procedure. This report shows that medical treatment of interstitial pregnancy may be an effective alternative to the surgical approach.

Adult↗
PubMed1997

The prognostic value of salpingoscopy.

Salpingoscopy enables the visual inspection of the ampullary mucosa during either laparotomy or laparoscopy. This prospective study correlates the salpingoscopic results with the postoperative pregnancy rates and evaluates the value of salpingoscopy against already existing classification systems. A total of 226 women diagnosed as having pelvic inflammatory disease were treated by microsurgery. There were no other causes of infertility in these patients. The collective was divided into patients with pure adhesive disease and those with supplementary distal tubal occlusion. Salpingoscopy was performed at the end of a microsurgical laparotomy. All laparotomies were performed between 1989 and 1992. The occurrence of pregnancy was checked after 42 months follow-up. A correlation between salpingoscopy and the American Fertility Society classification for each tube is discussed. The crude and cumulative intrauterine pregnancy rates are reported for the two patient groups.

Female↗
PubMed1995

[Hematometra after hysteroscopic endometrium ablation--a case report].

13 months after a hysteroscopic endometrial ablation a haematometra was diagnosed in a 44 year-old women as a source of recurrent pelvic pain. The cause of the haematometra was a complete obliteration of the ostium cervicae internum. This long-term complication of the endometrial ablation shows that all patients should have a regular clinical and sonographical follow up after endometrial ablation.

Adult↗
PubMed1992

Hysteroscopic treatment of congenital uterine malformations causing hemihematometra: a report of three cases.

To our knowledge, this is the first case report of hysteroscopic treatment of congenital uterine malformations with one-sided occlusion causing hemihematometra. This rare form of uterine anomaly should be considered when symptoms such as increasing pelvic pain start with menarche. A 9-mm resectoscope was used for dissecting the way into the occluded part of the uterine body. There the endometrium was ablated for prevention of recurrence of hemihematometra. By this endoscopic approach the disadvantages of laparotomy could be avoided in three adolescent patients.

Adolescent↗
PubMed1992

[Hysteroscopic resection of submucous myoma].

Between 1988 and 1991, 39 patients with intrauterine submucous fibroids were treated at the University of Düsseldorf, Department of Gynaecology and Obstetrics, by hysteroscopic resection. Myoma diameter ranged from 1 cm to 6 cm with a median of 2.6 cm. 29 patients had bleeding problems in form of meno-metrorrhagia; 14 patients suffered from infertility, 2 patients were treated by combined transabdominal-transcervical approach because of multiple myomata. One severe intraoperative complication occurred as an uterine perforation with injury to the small bowel. No other complication was seen. All patients with bleeding problems returned to normal menses after the operation. Four women became pregnant, one had an early abortion, one an ectopic pregnancy, two women delivered at term. Hysterectomy could be avoided in all cases.

Adult↗
PubMed1991

[Pregnancy after combined microsurgical and hysteroscopic surgical procedure in a patient with uterus septus and vagina septa].

Disturbances in the development of the Müllerian duct system may cause different forms of genital anomalies. We report on a patient with uterus septus and vagina septa, undiagnosed for years, and consequently successfully treated for infertility, who became pregnant immediately after combined microsurgical and operative-hysteroscopic treatment. The pregnancy proceeded without any complications. The patient delivered a healthy girl in the 41st week of gestation.

Adult↗
PubMed1991

[Experience with hysteroscopy or ultrasound-controlled removal of an intrauterine spiral with no visible thread in early pregnancy].

In case of intrauterine pregnancy with an intrauterine device (IUD), it is recommended, to remove the device because of the risk of abortions or septic complications. If the thread of the IUD is not visible, which often occurs because of growth of the uterus in pregnancy, it is advisable, to perform extraction by hysteroscopy or ultrasonic guidance. We report on 13 cases with hysteroscopic or ultrasonic guided IUD extraction in early pregnancy. 11 resulted in healthy infants, two pregnancies are continuing without complications.

Female↗