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Biomedical subjects

J Hugeneck

Publications and source records attributed to J Hugeneck.

5 recordsLinked to original sources

Nontufted incisional slit grafting.

BACKGROUND: The nontufted incisional slit grafting method described here is a decisively modified technique in the field of hair transplantation. OBJECTIVE: Traditional techniques of incisional slit grafting have the risk to produce a tufted look due to compression from the sides when the grafts are placed in the incision. METHODS AND RESULTS: Our specific method of dissection of the donor hair creates very small flat grafts that are the same shape as the recipient sites and includes trimming the epidermis and a part of the dermis. The advantage of this technique is that there is no compression on the grafts and thus it results in a diminished tufted look. CONCLUSION: With this technique it is possible to transplant more than 2000 grafts in one session, meaning that patients with extreme baldness and a relatively small fringe of hair can become hairy in an aesthetically pleasing way due to the extremely economic redistribution of the donor hair.

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[The intra-arterial infusion. II. Its use in the treatment of septic gangrene].

The local toxicity of Cefazolin was evaluated for the arterial endothelium. 37 patients with septic gangrena were treated by intraarterial infusions of standardized Cefazolin infusions into the arteries of the involved legs. In the average 11.6 infusions were applied for one leg. The bacteriology of the infected gangrenous legs is discussed as well as the sensitivity of antibiotics of the germs found. A progression of the gangrena could be prevented in 78% of the cases, only minor surgical measures, such as borderline amputations or plastic interventions were necessary. No side effects due to the local application of the drug were observed. The intraarterial continuous infusion of broad band antibiotics for septic gangrena is recommended.

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[Intra-arterial infusion. I. Kinetic studies on local blood levels].

In dogs the concentrations of agents infused continuously into arteries were assessed in the local and in the systemic circulation. An equation for the gradient between the local and the systemic circulation indicates that in the steady state the gradient is directly proportional to the total clearance of the infused drug and inversely proportional to the blood flow in the infused artery. Within certain limits the gradient is independent of the infused quantity of the drug. By local infusions of antibiotics, such as cefazolin a considerably higher local concentration can be achieved if the local blood flow is impaired, e.g. by arterial disease. By local infusions of streptokinase an increased local fibrinolysis was observed only when the arterial circulation was considerably reduced. Local intraarterial continuously infusions of pharmacologic agents are especially recommended for patients with arterial disease.

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