PubMed Health⌕ Search

Biomedical subjects

J Hunsballe

Publications and source records attributed to J Hunsballe.

2 recordsLinked to original sources

Sleep studies based on electroencephalogram energy analysis.

Current sleep studies use the manual polysomnographic technique or frequency analysis when investigating the mechanisms behind the incomplete transition from sleep to consciousness. Ten control subjects and 11 primary monosymptomatic enuretics were studied in a sleep laboratory for three consecutive nights (23.00-07.00 h). The results showed no significant differences in sleeping pattern between enuretics and controls. Enuretics spent more time in stage 3 sleep than controls on recovery nights, indicating greater depth of sleep. No differences in sleep architecture were noted between the groups on baseline nights, although enuretics showed a shorter total sleep period than controls on the recovery night. Increased delta waves exhibited in the enuretic group are indicative of a greater depth of sleep. Moreover, electroencephalogram readings showed an impaired arousal in enuretics, which suggests that sleep may be a part of the pathology of enuresis.

Adult↗

Fluid deprivation in enuresis--effect on urine output and plasma arginine vasopressin.

Desmopressin responders tend to have a large volume of urine production at night, in contrast to desmopressin refractory patients who often produce normal volumes of urine. Controls and adolescent/adult primary monosymptomatic nocturnal enuretics were included in a study measuring urine volume and plasma vasopressin levels before and during a 24-hour water deprivation test. The results indicate a significantly higher urine production in desmopressin responders when compared with controls and non-responders. Before fluid deprivation, only the nocturnal polyuric patients showed a urine osmolality significantly lower than that of controls and desmopressin non-responders. A significant decrease in the clearance of osmols was evident in the desmopressin refractory group from day to night. All three groups showed a significant increase in plasma vasopressin during fluid deprivation, with polyuric, desmopressin-responding patients showing a lower increase that the non-responders and controls. Plasma vasopressin levels were normal in adolescent and adult enuretics regardless of their response to desmopressin. Moreover, response to fluid deprivation in both polyuric and enuretic patients resulted in a significant decrease in urine output from the first to the second night.

Administration, Intranasal↗