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Biomedical subjects

J Hunziker

Publications and source records attributed to J Hunziker.

9 recordsLinked to original sources

Small animal traversing gamma counter.

A whole body traverser was developed that provides a variety of radionuclide detection configurations for retention and distribution studies. Data from biologically incorporated radionuclides were shown to be less susceptible to geometrical problems with this whole body traverser than with the usual forms of whole body counters. When used in its fully rotational mode, the effects of photon energy and attenuation due to various body tissues, thicknesses, and radionuclide locations were minimized. Consistent presentation of all aspects of the sample produced greater than 95% correlation with the predictable data and less than 2% counting fluctuations. The whole body traverser was utilized in radiolabeled microsphere tracer studies for the determination of regional blood flow and as a static counter for long term retention studies.

Aging

Evaluation of a new rat feeder for use in chemical toxicology and nutrition studies.

A rat feeder was designed, fabricated, and evaluated which eliminated many of the problems associated with commercially available rat feeders (such as inadequate feed capacity, excessive feed spillage, excessive feed contamination, and difficulties with cleaning feeders). The feeder was capable of holding up to 700 g of meal-type feed. It provided rats with a continuous supply of diet which was virtually free from feces and urine contamination. Feed waste due to spillage and inaccessible feed was minimal and estimated to average 0.8%. Growth and weight maintenance in weanling and adult rats using the feeder were similar when compared to rats receiving pelleted feed ad libitum.

Animal Feed

A new feeder system for quantitating actual toxicant consumption by mice during feeding studies.

A new mouse feeder system was described which enables mice to be utilized for long-or short-term feeding studies of chemical toxicants. Quantitative toxicant consumption can be obtained. The use of granulated feed of particle size, 500-1000 mu, prevents bridging, thus assuring a constant supply of diet to the experimental animals. Comparative weight gain in female BALB/c Nctr BR mice showed no significant differences between the groups fed 500 ppm 2-fluorenylacetamide, control granulated feed, or pellets.

Acetamides