Biomedical subjects
Publications and source records attributed to J Hutson.
An infant who presented with Hirschsprung's disease was found to also have the clinical features of persistent Müllerian duct syndrome and on testing to have Müllerian inhibiting substance deficiency. This association has not been previously reported. While this may be a coincidence, recent reports indicate intersex conditions can be associated with Hirschsprung's disease.
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We have used a 1.05-kb unique genomic fragment from the 5' end of the apolipoprotein (apo) CIII gene to identify a restriction fragment length polymorphism (RFLP) detected with the restriction enzyme PvuII, in the apoCIII-apoAIV intergenic region. In a sample of 220 normolipidaemic individuals from the UK population, the frequency of the rare allele, VB2 is 0.054. The PvuII polymorphism is in apparent linkage equilibrium with three other RFLPs of this gene cluster, detected with the restriction enzymes XmnI, PstI and SstI, but in linkage disequilibrium with an RFLP in the apo-CIII gene also detected with PvuII. Taken together, these five RFLPs have a PIC (polymorphism information content) value of 0.8, and therefore are informative for genetic studies. Individuals with the genotype VB1VB2 had lower mean concentrations of apoAI, and HDL-cholesterol than individuals with the genotype VB1VB1. However these differences were not statistically significant.
The reaction of the urethra to two new polyurethrane polymers was compared with those produced by materials currently used in the manufacture of urethral catheters. The comparison included silicone, latex rubber, tetrafluoroethylene polymer (Teflon) coated latex, and polyvinyl chloride. There were no significant differences in the reaction of the urethra to the various materials. The present study was carried out in the absence of bacterial contamination.
Cystotomies were performed on mature guinea pigs using aseptic technique, and one layer closure with polypropylene sutures. It was found that epithelialization over the suture material was completed by 3 days and that epithelialization of the bladder mucosa itself after a mucosa-mucosa approximation was completed within 4 days. The main significance of this investigation is that the normal bladder mucosa was completely healed within 4 days.
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