PubMed Health⌕ Search

Biomedical subjects

J I Casey

Publications and source records attributed to J I Casey.

18 recordsLinked to original sources
PubMed1984

Group B streptococcal arthritis in adults.

Group B streptococcal arthritis in adults is uncommon. This report describes seven cases seen at these institutions over the past five years and reviews the previous 17 documented cases. Of seven adults, three were diabetics, three had prosthetic hips, and one had undergone splenectomy. Six had undergone no prior dental, genitourinary, or gastrointestinal procedures. The most common clinical presentation was fever and acute joint pain. Five patients had monoarticular arthritis; two had multiple joint involvement. Underlying joint abnormalities included osteoarthritis (two), prosthetic hip (three), and neuropathic joint (one). Bacteremia was documented in three and suspected in the remaining four patients, often without a primary source. Therapy included parenteral antibiotics, usually penicillin G, and drainage of the involved joint. Two of three patients with prosthetic implants required Girdlestone procedures; the third was apparently cured. The three diabetic patients died, one with resolution of group B streptococcal arthritis. The seventh patient was cured. Group B streptococcal arthritis is a serious infection in adults with diabetes and late prosthetic hip infections.

Adolescent↗
PubMed1982

Comparison of carriage rates of group B streptococcus in diabetic and nondiabetic persons.

In several published studies, diabetic persons appeared to be at increased risk for Group B streptococcal disease. Since colonization with pathogens frequently antedates disease, the authors studied the carriage rate of Group B streptococcus in 38 diabetic and in 39 nondiabetic age- and sex-matched subjects. Fifty-four per cent of the controls and 34% of the diabetics carried Group B streptococci in at least one of five sites cultured (p less than 0.05). The data indicate that an increased carriage rate of Group B streptococci cannot be invoked as a reason for the increased numbers of diabetic persons among patients with Group B streptococcal infections.

Adult↗
PubMed1979

Streptococcus bovis septicemia and carcinoma of the colon.

We prospectively studied patients with Streptococcus bovis septicemia for the presence of gastrointestinal lesions. This study was prompted by our reported findings of the association of fecal carriage of S. bovis with carcinoma of the colon. We studied 29 patients with 30 episodes of S. bovis septicemia. Fifteen completed gastrointestinal evaluations that included colonscopy, surgery, or autopsy. Eight of these had carcinoma of the colon, three had adenomatous polyps of the colon without carcinoma, and two had carcinoma of the esophagus. The 14 patients who did not have complete evaluations included one each with carcinoma of the stomach, gastric lymphoma, and adenomatous polyp of the colon and three with colonic masses not further delineated. Nineteen patients had no gastrointestinal signs or symptoms or stools positive for occult blood at admission. The results of our study suggest that all patients with S. bovis septicemia need aggressive evaluation of the gastrointestinal tract, especially the colon.

Adenocarcinoma↗
PubMed1977

Association of Streptococcus bovis with carcinoma of the colon.

Two patients with colonic adenocarcinoma and Streptococcus bovis endocarditis suggested a possible association between the two. Non-enterococcal Group D streptococci were isolated from fecal cultures of 11 of 105 controls, 35 of 63 patients with carcinoma of the colon, seven of 25 with inflammatory bowel disease, four of 21 with non-colonic neoplasms and five of 37 with other gastrointestinal disorders. All such streptococci examined for lactose fermentation were S. bovis. The prevalence of S. bovis in fecal cultures from patients with carcinoma of the colon was significantly increased (P less than 0.001) as compared to that in controls, and also to all other groups (P less than 0.001). No other group had results significantly different from those of controls (P less than 0.05) although patients with inflammatory bowel disease were more frequently carriers. The carrier state was unrelated to age, hospitalization status, colonic stasis, gastrointestinal bleeding or recent barium-enema examination. The implications of this association are unknown.

Adenocarcinoma↗
PubMed1977

Impaired response of lymphocytes of diabetic subjects to antigen of Staphylococcus aureus.

The lymphocyte response to antigen of Staphylococcus aureus was examined in 67 uninfected diabetic subjects and in 71 age-matched subjects who were not diabetic. Peripheral blood lymphocytes were exposed to phytohemagglutinin and to antigen of S. aureus in triplicate cultures in the lymphocyte transformation assay. Diabetic subjects including those who were in good metabolic control had significantly decreased responses to staphylococcal antigen (P less than 0.05) but not to phytohemagglutinin. The use of fetal calf serum in place of autologous plasma in the nutrient medium did not correct the defect. Lymphocytes from normal subjects were cultured in diabetic plasma as well as in autologous plasma; the differences were not significant. These findings indicate that diabetic persons have an impaired response to staphylococcal antigen, a defect which appears to be in the lymphocyte itself and not in the serum factor.

Adolescent↗
PubMedDate not supplied

Streptococcus equinus septicemia: report of two cases and review of the literature.

Two cases of septicemia with Streptococcus equinus, a group D streptococcus, are reported, and the literature pertaining to infections with this organism is reviewed. Both of our patients presented with obvious signs of infection, had S equinus isolated from multiple blood cultures, and had a good clinical response to penicillin therapy, alone or in combination with streptomycin. In vitro testing of the isolates confirmed susceptibility to penicillin. S equinus should now be recognized as a human pathogen as are the other group D streptococci, S bovis and the enterococci.

Aged↗