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Biomedical subjects

J I Hirsch

Publications and source records attributed to J I Hirsch.

48 records · Page 3Linked to original sources
PubMed1981

Insulin adsorption to polyolefin infusion bottles and polyvinyl chloride administration sets.

The availability of various dosages of insulin from a new collapsible polyolefin bottle fitted with a conventional polyvinyl chloride administration set was studied. Intravenous solutions containing various dosages of insulin (20, 40, 70, and 100 units), to which 125I-labeled insulin was added, were prepared. Solutions were mixed and delivered at a maintained flow rate of 125 ml/hour. Effluents were collected at 15, 30, 45, and 60 minutes and then at hourly intervals up to seven hours. One-milliliter samples were drawn from the end of the administration set at the end of each interval, and the level of radioactivity in the sample was measured. Greater percentages of binding occurred at the lower levels of insulin added. Saturation limits of 7.8, 2.7, and 5.4 units were found for the system, administration set, and bottle, respectively. Adsorption values for this bottle were less than that found in another study for polyvinyl chloride.

Adsorption↗
PubMed1981

Effects of pulmonary vascular recruitment on gamma scintigraphy and pulmonary capillary protein leak.

Pulmonary vascular recruitment (PVR) was altered and lung-heart radioactivity ratio (L:H) measured using 99mTc-tagged human serum albumin (Tc-HSA) in five dogs each by inflating a left atrial balloon (LAB) to produce a 20 mm Hg pulmonary capillary wedge pressure (PCWP) or opening a 5 mm diameter aortoinferior caval shunt (ACS) before and after oleic and injury. Cardiac output (CO), pulmonary arterial pressure (PAP), and PCWP were measured with each alteration in PVR. In an additional 10 dogs, multiple doses of Tc-HSA, administered over 5 hours, 2 hours after 0.1 ml/kg oleic acid, produced parallel "slopes of injury" over the 5-hour period. Each rise in PVR was associated with an acute increase in L:H but demonstrated no significant increase in slope after equilibration. Closure of the ACS or LAB deflation returned the L:H to projected baseline. A "slope of injury" (P less than 0.001) was seen after the administration of oleic acid, which was significantly (P less than 0.01) steeper with an increased PVR. This was confirmed by repeat doses of Tc-HSA. This study confirmed the following hypotheses: (1) the "slope of injury" curves were reproducible so that the effects of experimental interventions on the rate of protein leak could be determined; (2) the L:H rapidly became constant after an acute change in PVR prior to oleic acid injury: and (3) a raised PVR would increase the rate of albumin leak after pulmonary microvascular injury.

Animals↗
PubMed1977

Allergic reaction to Patent Blue Violet during lymphography.

A case of an allergic reaction to Patent Blue Violet dye used for the purpose of lymphangiography is reported. The clinical findings were urticarial reaction, edema of the eyelids and lips, and hypotension. Previous sensitization to triphenylmethane dyes, in drugs and other chemicals was likely, but not proven. Such commonly used compounds have been compiled in a Table. History of a previous hypersensitivity reaction to these compounds is not a contraindication for lymphangiography but should call for emergency planning and possible premedication.

Adult↗
PubMedDate not supplied

Single isotope evaluation of pulmonary capillary protein leak (ARDS model) using computerized gamma scintigraphy.

Using a canine oleic acid model, a computerized gamma scintigraphic technique was evaluated to determine 1) ability to detect pulmonary capillary protein leak in a model temporally consistent with clinical adult respiratory distress syndrome (ARDS), 2) the possibility of providing a quantitative index of leak, and 3) the feasibility of closely spaced repeat evaluations. Study animals received oleic acid (controls, n = 10; 0.05 ml/kg, n = 10; 0.10 ml/kg, n = 12; 0.15 ml/kg, n = 6) 3 hours prior to a tracer dose of technetium-990m (99mTc) HSA. One animal in each dose group also received two repeat tracer injections spaced a minimum of 45 minutes apart. Digital images were obtained with a conventional gamma camera interfaced to a dedicated medical computer. Lung: heart ratio versus time curves were generated, and a slope index was calculated for each curve. Slope index values for all doses were significantly greater than control values (P(t) less than 0.0001). Each incremental dose increase was also significantly greater than the previous dose level. Oleic acid dose versus slope index fitted a linear regression model with r = 0.94. Repeat dosing produced index values with standard deviations less than the group sample standard deviations. We feel this technique may have application in the clinical study of pulmonary permeability edema.

Animals↗