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Biomedical subjects

J I López

Publications and source records attributed to J I López.

At least 19 recordsLinked to original sources
PubMed2006

The combination of millimetres of cancer and Gleason index in core biopsy is a predictor of extraprostatic disease.

AIMS: The Gleason index (GI) is related to several pathological endpoints in radical prostatectomy (RP) specimens, including the risk of extraprostatic disease (ED). The amount of tumour (TM) in core biopsy (CB) specimens also correlates with staging. The aim was to determine whether the sum of the relative statistical weights of GI and TM in CBs strengthens the prediction of ED in RPs. METHODS AND RESULTS: A series of 290 RPs and their previous respective CBs were reviewed. TM and the GI were blindly evaluated in CBs and statistically correlated with ED in RPs. A total of 60 (20.6%) RPs showed ED. The logistic regression model indicated that all cases with > 22 mm of cancer in CB showed ED in RP. All cases with a GI > 7 and > 12 mm of cancer in CB displayed ED. Finally, Pearson's chi2 revealed that 80% of cases with a GI > 7 and > or = 5 mm of cancer in CB showed ED in RP. CONCLUSIONS: The combined evaluation of GI and TM in CB is a useful method to strengthen the prediction of ED, is based on two simple morphological criteria and may be used as an additional tool to choose the best treatment modality.

Adult↗
PubMed2004

[Phosphotyrosine phosphatase SHP-1, somatostatin and prostate cancer].

We review the mechanisms involved in prostatic growth based on androgens and product of neuroendocrine secretion, with special reference to the role of somatostatin (SS) in the inhibition of neoplastic growth. Our contributions in the field confirm the antiproliferative effect of SS on the prostate is mediated by phosphotyrosine phosphatase SHP-1, that is present in human prostate. This enzyme plays a role in the control of prostatic cell proliferation and in the progression of prostate cancer. Besides, we consider its presence may determine the therapeutic potential of SS in the control of prostate cancer.

Biomedical Research↗
PubMed2001

Papillary squamous cell carcinoma of the larynx.

A case of papillary squamous cell carcinoma of the larynx in a 50-year-old man is reported. The lesion was located in the supraglottic region and grossly presented a characteristic finger-like pattern of growth. The tumour pursued an indolent clinical course, and the patient is well and free of disease after 47 months of follow-up. The present paper recapitulates the macro- and microscopic features of this rare neoplasm and stresses its differential diagnosis with other exophytic squamous cell carcinomas of the region.

Carcinoma, Squamous Cell↗
PubMed2001

Inflammatory myofibroblastic tumour of the larynx.

A case of inflammatory myofibroblastic tumour of the larynx in a 74-year old man is reported. The lesion presented as a polypoid tumour arising in the left true vocal fold. The patient died of non-tumour-related causes and the autopsy showed persistence of the laryngeal tumour. Multicentricity and distant metastases were not detected. The literature about this entity and its differential diagnosis is reviewed and briefly commented upon.

Actins↗
PubMed1997

Glandular-type inverted papilloma of the prostatic urethra.

A case of inverted papilloma of glandular type in the prostatic urethra of a 65 year-old man is reported. The case was asymptomatic and incidentally discovered on histopathologic study of transurethral resection (TUR) specimens from benign prostatic hyperplasia. The literature concerning this rare entity is reviewed and briefly commented.

Aged↗
PubMed1996

Meningioangiomatosis and oligodendroglioma in a 15-year-old boy.

A case of meningioangiomatosis occurring in a 15-year-old boy is reported. The patient did not show signs of neurofibromatosis on physical examination, and his medical history included only one previous episode of loss of consciousness, which was accompanied by a self-limited focal seizure. The lesion was associated with an oligodendroglioma and was incidentally discovered during the macroscopic sampling of the neurosurgical specimen. The literature relating to this uncommon entity is reviewed and discussed. To the best of our knowledge, the concurrence of meningioangiomatosis and oligodendroglioma has not been documented previously.

Adolescent↗
PubMed1996

[Prognosis prediction in patients with transitional cell carcinoma of the urinary bladder].

OBJECTIVES: Many attempts have been made during decades to identify factors predictive of prognosis in patients with transitional cell carcinoma (TCC) of the bladder. The present study attempts to determine the predictive factors in a large series of patients with long follow-up homogeneously treated at three institutions from 1983 to 1992. METHODS: The clinical and histological factors with presumed prognostic value were retrospectively evaluated in a series of 331 patients with a mean follow-up of 7.2 years, and a study of survival was performed. RESULTS: Univariate analysis showed tumor stage, growth pattern, grade, size, coexisting dysplasia, histologic type, topography of the lesion and patient age are useful parameters for the prediction of prognosis. The Cox analysis revealed tumor stage is the most important prognostic variable (Beta = 1.23, p < .001), followed by growth pattern as determined by the presence or absence of a papillary phenotype (Beta = 1.18, p < .001), tumor size (Beta = .98, p < .001), WHO modified histologic grading considering persistence or loss of cell polarity (Beta = .73, p < .01), tumor location (Beta = .48, p < .05), and histology (presence or absence of phenotypes other than pure TCC, Beta = .45, p < .05). Coexisting dysplasia, tumor multiplicity, age and sex did not independently influence survival. CONCLUSION: Despite the advancements in the field of molecular biology relative to prognostic markers in bladder cancer, the conventional morphological parameters and tumor stage continue to be the main source of prognostic information in clinical practice.

Adult↗
PubMed1995

Well differentiated neuroendocrine carcinoma of the breast. A case report.

A neuroendocrine breast carcinoma occurring in a 79 year-old woman is presented. The case presented typically as a single nodule in the upper and outer quadrant of her right breast and showed a pure histology consisting exclusively of organoid nests of well differentiated cells that mimicked those of carcinoid tumors of the lung. The literature is briefly reviewed and commented. In the light of this review, we conclude that the issue of carcinomas with neuroendocrine differentiation in breast pathology is controversial and its terminology somewhat debatable.

Aged↗
PubMed1994

Phyllodes tumor of the breast. An immunohistochemical study of 28 cases with special attention to the role of myofibroblasts.

The presence of myofibroblasts in the stroma of Phyllodes tumor of the breast has been documented in single cases by means of electron microscopy and immunohistochemistry. In this study, we re-evaluate the immunophenotype exhibited by 28 Phyllodes tumors (14 benign, 6 borderline and 8 malignant) in order to state the relevance of myofibroblasts as active stromal elements in these tumors. Vimentin showed positive immunostaining in the stroma of all the cases (100%), muscle-specific actin in 21 (75%), and desmin in 7 (25%). By contrast, stromal cells were uniformly negative for S-100 protein, keratins (AE1/AE3 and CAM 5.2), and epithelial membrane antigen (EMA). The epithelial component showed the typical two-layered arrangement of ducts in every case. Myoepithelial (outer) cells immunostained with muscle-specific actin and S-100 protein, and in some cases with EMA and keratins, whereas the epithelial (inner) layer did so with keratins and EMA. To conclude, we have found a prominent myofibroblastic differentiation in stromal cells of many of such tumors. Our results also prove that no differences in intensity or distribution of such actin-positive stromal cells are seen between benign, borderline or malignant counterparts.

Actins↗