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Biomedical subjects

J I Perold

Publications and source records attributed to J I Perold.

4 recordsLinked to original sources

Massive thymic hyperplasia.

Massive thymic hyperplasia is an extremely rare form of true thymic hyperplasia most often described in infants and children. Hyperplasia of this order is not known to occur in any other organ, and its etiology and prognostic significance remain unknown. As there is no accurate way of preoperatively differentiating massive thymic hyperplasia from other tumors of the thymus and anterior mediastinum, we advise excision in all cases for histological analysis and relief of mediastinal compression. This description of 4 cases updates the 30 previously reported cases, and includes a literature review.

Child, Preschool↗

Sinus histiocytosis with massive lymphadenopathy. A case report.

A case of sinus histiocytosis is reported. This apparently rare disease was first described in 1969. The patient presented with a large, painless, bilateral cervical adenopathy which regressed completely over a 16-month period. Histological examination of a lymph node specimen showed sinuses distended with foamy histiocytes. Intervening lymphoid tissue showed a tremendous increase in plasma cells which distorted the normal architecture of the lymph node. The importance of accurate pathological diagnosis is again noted.

Adolescent↗

Pseudosarcoma of the oesophagus. A case report.

Pseudosarcoma is a malignant, polypoid tumour which has been described in the oesophagus, mouth, fauces and larynx. The tumour consists of a special variety of squamous cell carcinoma. Although squamous carcinoma of the oesophagus is especially prevalent in the East London area, there does not appear to be a corresponding increase in the incidence of pseudosarcoma. We report a case of pseudosarcoma encountered in a series of 5 000 cases of squamous carcinoma of the oesophagus.

Esophageal Neoplasms↗