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Biomedical subjects

J Ilson

Publications and source records attributed to J Ilson.

10 recordsLinked to original sources
PubMed1985

Tetrabenazine induces acute dystonic reactions.

Four patients suffered acute dystonic reactions caused by tetrabenazine. Because dystonic reactions have previously been reported only after dopamine receptor blockade and not with dopamine depletion, it is likely that the ability of tetrabenazine to induce acute dystonia is due to its dopamine receptor blocking properties. Because tetrabenazine can induce acute dystonia even when combined with alpha-methyl-p-tyrosine, presynaptic dopamine stores may not be necessary for these reactions to occur.

Acute Disease↗
PubMed1984

Pergolide therapy for Parkinson's disease: neurobehavioral changes.

Pergolide mesylate, a long-acting dopamine agonist, is effective in treating Parkinson's disease. Behavioral change is said to be one adverse effect. We therefore studied 19 parkinsonian patients with neuropsychological tests before and after initiating pergolide therapy. Intellectual and behavioral changes were also monitored clinically for up to 2 years. There was no decline in performance on the neuropsychological tests. Six patients had transient psychiatric or intellectual changes that were controlled by reducing drug dosage. These changes were similar to those seen with other dopamine agonists.

Adult↗
PubMed1983

Perceptual motor dysfunction in Parkinson's disease: a deficit in sequential and predictive voluntary movement.

We studied the ability of Parkinsonian patients and controls to generate voluntary movements on a tracing task. Subjects were videotaped while tracing designs of increasing complexity, presented on a vertical, transparent screen. Some designs were presented in a degraded form and subjects filled in their missing sections. Subjects also received a constructional task and a test of general intellectual ability. The quality of errors on the tracing task differed in the Parkinsonian and control groups. Parkinsonian patients made two distinct types of errors. One probably related to the motor disorders of the disease, but another seemed to be related to a higher level of control over sequential and predictive movements. The latter correlated with performance on the constructional and general intellectual tasks. These results suggest that Parkinson's disease may affect basal ganglia structures that are necessary for voluntary movements which require sequencing or planning. Clinically this may be observed in perceptual motor tasks since they require both voluntary movement and sequential organisation of behaviour.

Aged↗
PubMed1982

Tardive dystonia: late-onset and persistent dystonia caused by antipsychotic drugs.

It is not widely recognized that antipsychotic drugs can cause late-onset and persistent dystonia. This dystonia, which we call tardive dystonia, is to be distinguished from acute dystonic reactions, which are transient, and from classic tardive dyskinesia, which is a choreic disorder that predominantly affects the oral region. We present 42 patients with tardive dystonia. The age of onset of dystonia was 13 to 60 years. Symptoms began after 3 days to 11 years of antipsychotic therapy. Younger patients tended to have more generalized dystonia. In a few patients, spontaneous remission occurred, but dystonia persisted for years in most. Therapy was rarely a complete success. The most frequently helpful medications were tetrabenazine (68% of patients improved) and anticholinergics (39% improved).

Adolescent↗
PubMed1976

Physical therapy as a determinant of change in the cerebral palsied infant.

Twenty-four children under 18 months of age with an initial diagnosis of cerebral palsy were observed for minimum of six months on either experimental or control physical therapy programs using a double-blind study design. Medical and therapy evaluations indicated definite changes in motor, social, and management areas for those subjected to the experimental procedure and particularly among children expected to show higher intelligence. Change is found to be somewhat correlated with age at entry to the study and is more often associated with less actual treatment time. Findings suggest the need for additional treatment modalities for the youngest children who are most likely to have the greatest global involvement.

Age Factors↗