PubMed Health⌕ Search

Biomedical subjects

J Ipsen

Publications and source records attributed to J Ipsen.

At least 19 recordsLinked to original sources
PubMed1985

Effect of combined alcohol and tobacco exposure on risk of cancer of the hypopharynx.

The effect of moderate to heavy exposure to alcohol and tobacco on the risk of cancer of the hypopharynx is estimated in a case-control study. All incident hypopharyngeal cancer patients in Denmark who were under 75 years of age were compared with incident cases of laryngeal cancer and population sampled controls. The ascertainment of cases and controls took place during March 1980 to March 1982. Thirty-two patients with cancer of the hypopharynx, 321 patients with cancer of the larynx, and 1141 population sampled controls participated in the study. The effect of combined exposure to alcohol and tobacco seemed to be multiplicative rather than additive, a finding which is similar to that in laryngeal cancer patients. However, as there were only small numbers, only major deviations from the additive or multiplicative model for interaction would be detectable.

Aged↗
PubMed1984

Oral and intravenous acyclovir are equally effective in herpes zoster.

In a double-blind randomised trial 40 patients above 60 years old with acute herpes zoster received either 5 mg/kg acyclovir three times daily intravenously or 400 mg acyclovir five times daily orally for five days. Identical results were obtained with respect to duration of pain and rate of healing. Twenty per cent of orally administered acyclovir was absorbed and gave satisfactory concentrations of acyclovir in the vesicular fluid.

Acyclovir↗
PubMed1984

The ubiquitous 2X2 table, its parameters and their confidence limits.

The confidence limits for all parameters derived from a 2X2 contingency table are uniquely determined by the limiting matrices that arise from adding or subtracting certain values to or from the four cell entries. Various methods to determine these addends are discussed and a computer program is presented that produces reliable results. The limiting matrices thus produced bypass the more complicated expressions for the standard errors of the many epidemiological parameters that are used to interpret the 2X2 table.

Epidemiologic Methods↗
PubMed1984

Prevention of relocation of the aged in nursing homes.

In the period 1972-76 a descriptive and experimental socio-geriatric longitudinal investigation was carried out in the municipality of Odense. The aim of the experimental aspect was prevention of relocation of the aged in nursing homes. The practical work consisted in casefinding and social medical intervention by nurses experienced in geriatrics and in close contact with interdisciplinary groups. Emphasis was placed on familiarity with the structure of the social and health services, the provisions available, and with problem areas and deciding channels. Contact with the aged focused on gaining an overall impression of their situation, establishing mutual trust and cooperation. Aspects of the practical work that were emphasized were introduction to services, advice to the aged and personnel, coordination and follow-up for assessment of results. Twenty-three per cent of the age group 70-79 years and 51 per cent of the 80-years-olds and over were drawn randomly from the national person-register. In all, 4,128 persons were picked. They were then randomly divided into an intervention group and a control group. On December 31st, 1976, 154 persons from the intervention group and 189 from the control group had been relocated in nursing homes. The difference concerned mainly women over 80 years of age who had a statistically significant low relocation risk in the intervention group. Fewer elderly in the intervention group were relocated in nursing homes compared to controls after mid 74. Findings showed that on March 1st, 1983, duration of residence (survival) in nursing homes for the 343 persons who had taken up residency, was rather similar for both groups.(ABSTRACT TRUNCATED AT 250 WORDS)

Age Factors↗
PubMed1981

Treatment of trigeminal and thoracic zoster with idoxuridine.

A double-blind random selection comparison was made of the therapeutic effects in acute herpes zoster of 40% idoxuridine (IDU) dissolved in dimethyl sulphoxide (DMSO) compared with DMSO and saline flavoured with garlic. Thoracic (80 patients) and trigeminal (42 patients) zoster were investigated separately. The patients were evaluated daily until skin healing and then at 1, 3 and 6 months by registering pain, paraesthesia and sensitivity disturbances as well as by clinical and photographic evaluation of the skin lesions. Duration of pain was positively correlated to age, to delayed healing and to elevated temperature in the acute phase of zoster. The period of pain before skin eruption was considerably longer in thoracic than in trigeminal zoster, while the latter was associated with a more severe inflammatory reaction, more neurologic sequelae, but also by a faster healing of the skin lesions. IDU was highly effective in shortening the period of pain and improving skin healing in trigeminal zoster, while no effect of IDU was observed in thoracic zoster. The reason for this difference is presently not understood.

Aged↗
PubMed1979

Risk assessment of pulmonary embolism by multivariate analysis.

A prospective study of 6,527 hospitalized patients was performed to evaluate the effectiveness of multivariate analysis of risk factors to correctly designate risk for pulmonary embolism. History of previous pulmonary embolism was the single most important factor. In patients without prior history, five factors emerged: inactivity, congestive heart failure, Doppler ultrasound evidence of deep-vein occlusion, female sex, and black race. Used together, these factors permitted a discrimination of risk such that 68.7% of pulmonary embolization was found to occur in 32.2% of the population designated as showing increased risk. Multivariate analysis of clinical factors improved assessment of risk, compared to the use of lower extremity findings alone, and proved to be useful in identifying individuals at increased risk for pulmonary embolism.

Analysis of Variance↗
PubMed1979

Treatment of herpes zoster with idoxuridine ointment, including a multivariate analysis of symptoms and signs.

A double-blind, random selection comparison was made of the therapeutic effects in acute herpes zoster of (A) 40% idoxuridine (IDU) dissolved in dimethyl sulphoxide (DMSO), or one of the following ointments: (B) a basis of polyethylene glycol, (C) a basis with 60% DMSO, (D) a basis with 5% IDU and 60% DMSO, and (E) a basis with 40% IDU and 60% DMSO. Each group comprised 20 patients. The patients were evaluated daily until skin healing and then at 1,3, and 6 months by registering 4 neurological signs, 5 clinical evaluations of skin pathology and 4 photographic evaluations of the skin lesions. A 'profile' of the effect of each treatment was computed by calculating normalized means for each of the 13 variables. A non-random distribution of the clinical and photographic variables indicated a statistically significant, but small therapeutic effect of treatment A on skin healing, whereas no convincing effect on pain or sensitivity disturbances was established. Treatments B-E were without positive effects. The information given by the highly interdependent variables were computed for each variable and for groups of variables after appropriate scoring. It was found that the photographic evaluation contributed evidence independent of the clinical evaluation of skin pathology. A multiple correlation analysis revealed that age was positively correlated to the duration of pain and to delayed healing, that rapid healing was intimately connected to no or short-lived pain, and surprisingly that zoster in the trigeminal area healed faster than in other locations without being correlated to less pain. Treatment A must necessarily be reevaluated taking into account proper controls as well as age and affected dermatomes.

Adolescent↗