Leucocyte migration inhibition under agarose versus MEM test for detection of tumour-associated antigens.
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Antigens, Neoplasm↗
Biomedical subjects
J Irmscher
Publications and source records attributed to J Irmscher.
Immunological tumour profile: organ-specific carcinoma diagnosis in patients employing the macrophage electrophoretic mobility test.
The macrophage electrophoretic mobility (MEM) test provides a highly sensitive in vitro technique for the detection of cell-mediated immunity in man. The principle involved is the lymphokine-mediated reduction of the negative surface charge of guinea pig macrophages shown by the slowing of the macrophages during cell electrophoresis. Lymphocytes from 162 patients were tested by MEM. They were exposed to a battery of KCl extracts from normal and malignant human tissues, to encephalitogenic protein (EP), to carcinoembryonic antigen (CEA), and to thyroglobulin. Variable lymphocyte responses to EP, CEA and KCl extracts from different cancers gave MEM reaction profiles common to patients with carcinomas of the same organ origin.
Antigens, Neoplasm↗
[Epithelial sarcoma. Three case reports with a review of literature (author's transl)].
Starting from three own cases of an epithelioid sarcoma, the literature about this type of tumor is discussed. It occurs in males nearly three times as often as in females, with the maximum frequency between 20 and 29 years of age. Finger, hand, wrist and forearm are preferably affected with the epitheloid sarcoma. The microscopic features are: nodular growth, necroses and hemorrhages within the nodules, the tumor tissue consisting of spindle-type and epitheloid cells with spaces in between, and lymphocyte infiltrates and siderin deposits at the periphery. The neoplasm's cytogenesis is not known. With regard to the tumor, the differential diagnosis should make a clear-cut distinction particularly between inflammatory granulomas and benignant neoplasms. The tumor trends to reactivation to a large extent. Metastases are both lymphogenous and hematogenous. A radical surgical removal is strongly recommended.
Adult↗
[Studies on the immunologic specificity of the macrophage-electrophoresis mobility test in mice with syngeneic and allogeneic transplants of mammary carcinoma].
The study was performed to answer the question as to whether the macrophage electrophoretic mobility test (MEM-test) is suitable to detect allogeneic and syngeneic lymphocyte sensitization in the murine mammary tumour host system. Lymph node cells of both CBAf and XVII/Bln mice injected with allogeneic or syngeneic mammary tumour cells reacted specifically to hypertonic KCl extracts from allogeneic or syngeneic mammary tumours. Lymph node cells of nontreated control mice did not react at all. The MEM results reflect lymphocyte sensitizations which are specific with respect to the claim of transplantation and tumour immunology in the system employed.
Animals↗
[Cytochemical data in chronic monocytic leukemia].
4 cases of chronic monocytic leukemia were observed during several years. In 2 patients there was a final appearance of blastic crisis. During the course of the disease the activity of the naphthylacetate-esterase in the monocytes increased, but the PAS-reaction was lowered. By the help of two cases for comparison - one patient suffering from a chronic myeloid leukemia and intermediate monocytic phase, the other one from a panmyelopathia and monocytic reaction - the morphological resemblance of these phenomena is demonstrated, which cytochemically cannot be separated.
Aged↗