Biomedical subjects

J Isacson

Publications and source records attributed to J Isacson.

23 records · Page 2Linked to original sources

PubMed1987

Radiological findings in the rheumatoid knee joint in a seventeen-year follow-up.

In 1967 a population survey of rheumatoid arthritis (RA) was carried out in Stockholm. In a sample of 15,268 subjects, 239 were found to have RA. In 1983, i.e. 17 years later, all the 127 subjects still living could be traced, 109 of them were re-examined and 98 radiographed. Whole-leg weight-bearing radiographs of the 168 knee joints were available for determination of the HKA (Hip-knee-ankle) angle and of the articular space. In this sample, which represented the epidemiological spectrum of RA, disease activity could be associated with radiologic changes in the knee joint, e.g., erosions, cysts and sclerosis. These radiologic findings were predictable owing to the fact that New York criterion no. 3 or 4 for RA had been fulfilled 17 years earlier. In 52% of those with active RA at the follow-up, the articular space was seen to be narrowed. A certain varus angulation (2.2 degrees) was ascertained in the joints of subjects with inactive RA, while this angulation was less pronounced (0.7 degrees) in knee joints of subjects with an active disease.

Aged↗

PubMed1986

Three-dimensional electrogoniometric gait recording.

Gait recordings of twenty healthy subjects were made on a treadmill and on level ground by means of a light-weight computerised electrogoniometer. The angular excursions in three planes were recorded simultaneously with regard to hip, knee and ankle joints in both legs. Determinations of the mean values and dispersions were then made. In order to establish the reliability of the method tests and retests were performed. Also its validity was checked by comparing the goniometric recordings with concomitant measurements obtained by other methods. The reliability and validity of the method was found to be satisfactory. Apart from flexion of the hip and knee joints during stance phase (i.e. a difference of 2 and 2.4 degrees respectively), no difference was ascertained between walking on a treadmill and walking on level ground.

Adult↗

PubMed1984

Renal impairment after high doses of dicloxacillin-prophylaxis in joint replacement surgery.

The frequency of postoperative renal impairment after total hip and knee replacement was studied prospectively in 350 patients without signs of pre-existing renal disease. The first 278 patients were given dicloxacillin as prophylaxis against infection. In the remaining 72 patients dicloxacillin was excluded and gentamicin-impregnated cement was used as the only infection prophylaxis. In 35 patients in the first group (13 per cent), postoperative serum-creatinine was increased to pathological values. Thirteen of these patients were clinically affected, two had to be dialysed, and one died. In the second group there was no case of renal impairment. It is concluded that the systemic administration of antibiotics may be a cause of postoperative illness due to renal impairment.

Acute Kidney Injury↗

PubMed1982

Chronic sclerosing osteomyelitis (Garré).

Eight patients with chronic sclerosing osteomyelitis (Garré) were investigated for an average follow-up of 13 years. The disease is a well definable clinical entity affecting children and young adults. Secondary lesions occurred in four cases after an average of 5.5 years. Five patients with a history of an average of eight years duration were free of symptoms. whereas the remaining three patients with a history of six, 13, and 15 years, respectively, had intermittent recurrences. The roentgenologic findings showed pronounced sclerosis interspersed with cystic areas. In all cases except one the sclerosis remained unchanged or progressed, even when the patient was free of symptoms. There are indications that the condition may have its origin in an infection caused by low-virulent, anaerobic bacteria. Present methods of treatment appeared to have little, if any effect, on the progress of the disease.

Adolescent↗

PubMed1978

Management of redislocated Colles' fractures.

One question which often confronts the clinician is whether or not a Colles' fracture, shown to be redisplaced, should be subjected to renewed reduction. Earlier reports have shown a rather good correlation between the accuracy of reduction and the functional and cosmetic end result. Roentgenograms of 40 rereduced Colles' fractures are reviewed in order to answer the following questions. What are the chances of a lasting improvement resulting from a renewed reduction of a redislocated Colles' fracture? What is the most suitable time for renewed reduction? Permanent improvement was found in about 1/3 of all the case. To establish the most suitable time for rereduction the material was divided into early rereduced (1-6 days after primary reduction) and late rereduced (7-15 days) fractures. It was found that early rereduction led to lasting improvement of the fractures position in only 2 of the 15 cases. Late rereduction led to permanent improvement in 15 of 30 cases with respect to dorsal angulation and in 9 cases to radial compression. If a rereduction is to be performed, it should be done during the second week after primary reduction.

Adult↗