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Biomedical subjects

J Iványi

Publications and source records attributed to J Iványi.

At least 19 recordsLinked to original sources
PubMed1995

[Six-year follow up on recently diagnosed NIDDM patients].

The six-year prospective data on 100 newly detected NIDDM patients aged 40-69 years were analysed. After careful and controlled dietetic training, the carbohydrate metabolism parameters (glycohaemoglobin, mean blood sugar level and glycosuria), the physical status, fundus picture and laboratory data (lipids and renal function) were examined yearly and the alterations of the treatment were registered. 24 patients dropped out during six years. 10 patients died. The carbohydrate status was also favourable and a moderate weight reduction was reached. After two years 59% of the patients proved well controlled. At the end of six years 41% of the patients were still well controlled merely by dietary means. The data were compared with those on 100 similarly detected new NIDDM patients whose education and control were provided by family physicians. There were non essential differences between the two groups in specific complications, BMI and lipids. The level of carbohydrate metabolism control was significantly better in the diabetic clinic-controlled patients; the proportion of sulfanylurea-treated patients was only 40.5% after six years compared with 73% among family physicians-controlled patients. The importance of a correct and controlled diet, good education and continuous control is emphasized.

Adult↗
PubMed1994

Co-expression of c-abl and c-myb oncogenes in Philadelphia chromosome-negative, bcr-negative chronic myeloid leukaemia.

Three cases of Philadelphia (Ph) chromosome-negative, bcr-negative chronic myeloid leukaemia (CML) have been investigated for oncogene expression by Northern blot and cytoplasmic RNA dot blot hybridization. Considerably high levels of expression of c-abl and c-myb were observed in all cases. In the Ph-negative cells the normal 6.0 and 7.0 kb c-abl and 3.8 kb c-myb transcripts were found. No amplification of c-abl or c-myb oncogenes was detected in the DNAs of Ph-negative CML cells. Data suggest that co-operation between the overexpressed c-abl and c-myb oncogenes is causally related to Ph-negative bcr-negative CML.

Adolescent↗
PubMed1991

[Diabetic ketoacidosis (169 episodes in 131 patients in the course of 10 years)].

Diabetic patient material--presenting hyperglycaemic ketoacidotic episode--observed in Gyula and Szekszárd County Hospitals in period 1980-89, was reviewed by authors. 131 patients were admitted with 169 ketoacidotic episodes (among them 23 patients had 62 recurrences). The mean age of patients were 49.4 years (14-84 years), duration of diabetes 9.5 years (from one month to 45 years). The common cause of diabetic ketoacidosis was respiratory (26 per cent) and enteral (35.5 per cent) infection. The consciousness of patients had shown close correlation with the increase of blood sugar and urea nitrogen level as well as with the decreasing of the pH value of capillary blood. The first step of the therapy was the parenteral fluid intake with isotonic solution (in the first hour the average 1351 ml). In 18 patients fast-acting insulin (Novo Actrapid MC) was given by constant infusion, in the remaining cases intravenous or intramuscular low doses of the same insulin were administered. The importance of early potassium replacement, and the dangers of forced and rapid correction of acidosis is emphasized. Lethality related to episodes was 10 per cent, related to the patients 12.9 per cent. The number of ketoacidotic cases did not decrease parallel with the improvement of therapeutic possibilities, as it was experienced by their earlier evaluations. The importance of the prevention of acute metabolic disorders is outlined might be resulted from increasing the efficacy of patients education and better knowledge of GP's, as well.

Adolescent↗
PubMed1990

[The anti-lipidemic effect of Minipress].

Prazosin (Minipress) monotherapy was given to 152 patients with essential hypertension for one year in a multi-center study involving 13 hospitals and university clinics. In three centers serum levels of total cholesterol, HDL-cholesterol and triglycerides were also determined in 32 patients with hypertension and hyper/dys-lipoproteinemia. As a consequence of Minipress monotherapy significant decreases were found in serum level of cholesterol (after three months and also after one year), triglycerides (after one year), while the serum concentration of HDL-cholesterol increased. Atherogenic index (a ratio of total cholesterol over HDL-cholesterol) was significantly decreased by Minipress. As new data showing a causative correlation between hypertension and hyperlipoproteinemia were published in the literature authors, on the basis of their results, suggest to determine lipid profile in every patient with hypertension. They regard Minipress as the first line drug in young patients with "familial dyslipidemic hypertension". When choosing an antihypertensive drug metabolic side effects should be taken into consideration.

Coronary Disease↗
PubMed1989

[Insulin-induced lipoatrophy--caused by monocomponent insulin?].

Authors give case history of two patients for type II diabetes treated with insulin by whom with monocomponent insulin lipoatrophy developed on the region of insulin administration. In the case of one of them the problem was solved by elimination of technical fault, the local reaction of other patient ceased only by converting to human insulin into the lipoatrophic region. In the latter case dynamics of contemporaneous psoriatic change raises immunological connections.

Diabetes Mellitus, Type 1↗
PubMed1989

Observations with captopril (Tensiomin) treatment in hypertensive patients (one-year period).

In the treatment of patients suffering from therapy-resistant hypertension the angiotensin converting enzyme inhibitor captopril seems to be one of the most promising drugs of the past decade. The authors examined and followed the effect of captopril (Tensiomin) for one year in 13 severe therapy-resistant hypertensive patients. The average arterial blood pressure of 12 patients suffering from essential hypertension and 1 patient with renal hypertension was, before the introduction of captopril therapy, 215/120 mmHg (SD +/- 23/18). At the end of the one-year examination period the average blood pressure was 186/111 mmHg (SD +/- 25/19). The acute effect of captopril was found to be very favourable, and the required blood pressure fall could be obtained during its long-term use even in cases of renal failure. Except for one case multiple combination therapy had to be applied in all patients for the moderation of blood pressure (in 5 cases 4, in 2 cases 5, in 1 case 6 drugs). The long-term use of the drug did not influence notably the serum potassium-carbamide-creatinine and SGOT values or the white blood cell count. On the basis of their results the authors emphasize that the therapeutic effectivity of captopril monotherapy is not sufficient in severe therapy-resistant hypertension cases, its adjuvant action may be expected in drug combinations. With daily doses lower than 200 mg demonstrable side-effects did not occur.

Adult↗
PubMed1986

History of patients with chronic granulocytic leukaemia observed in 1974-1984.

138 CGL-patients were treated in 1974-1984. The female-male ratio was 1.26. In the majority (82.3%) of the 68 patients having died at the blastic phase, all three phases of the disease could be followed. The chronic phase lasted for 31 months. The accelerated disease was detectable in 56 patients, with a mean duration of 5.3 months. The blastic phase, lasting for 4.1 months, was morphologically heterogeneous. Using adequate methods, several groups could be distinguished, i.e. myeloid in 38.3, promyelocytic in 2.9, myelomonocytic in 19.1, megakaryoblastic in 14.7, lymphoblastic in 13.2 and mixed blastic in 11.8%. 23 patients died prior to the development of the blastic phase (9 in the chronic phase, 12 in the accelerated phase and two with chronic neutrophilic leukaemia). The mean survival was in accordance with that in the literature, i.e. 40.6 months. The shortest survival was shown by the lymphoblastic group with the difference manifesting already in the chronic phase. Females survived 13-14 months longer than did males.

Adolescent↗